Vaginal clindamycin and oral metronidazole for bacterial vaginosis: a randomized trial

Abstract

A 3-day regimen of clindamycin, given as intravaginal ovules, was as effective as and better tolerated than a 7-day regimen of oral metronidazole 500 mg, given twice daily, for treatment of bacterial vaginosis.

The Inhibitory Effect of Clindamycin on Lactobacillus in vitro

“…Clindamycin is frequently used in the treatment of BV in nonpregnant women [4][5][6][7][8][9][10][11] . The goal of effective BV treatment is not only inhibition of G. vaginalis and anaerobe growth, but also avoidance of a negative impact on the growth of Lactobacillus spp.…”

Polyethylene Glycol-Based Hydrogels for Controlled Release of the Antimicrobial Subtilosin for Prophylaxis of Bacterial Vaginosis

“…This procedure was chosen with the particular aim of evaluating the final effect of the stressor on the targeted microorganism rather than to study the kinetics of bacterial growth in the presence of the antimicrobial. Hydrogels (4% [wt/vol]) with various amounts of subtilosin (8,12,15, and 20 g per 50 l of gel) were prepared in a 96-well plate. In addition, hydrogels with no entrapped subtilosin were prepared in order to evaluate the possible effect of the hydrogel alone on G. vaginalis growth.…”

“…in the presence of subtilosin-containing hydrogels. The growth of four strains of vaginal lactobacilli (L. acidophilus, L. gasseri, L. plantarum, and L. vaginalis) in the presence of subtilosin-containing hydrogels was evaluated as follows: hydrogels (4% [wt/vol]) with subtilosin (8,12, and 20 g per 50 l of hydrogel) and subtilosin solutions (50 l/well in PB; final concentrations of 8 to 20 g/ml per well) were prepared in a 96-well plate. In addition, hydrogels with no entrapped subtilosin were prepared in order to evaluate the effect of the hydrogel alone on lactobacilli growth.…”

“…However, the recurrence rate for BV is high, with cure rates of only 60 to 70% after a month of treatment (12)(13)(14)(15). Another concern with the current antibiotic treatments for BV is the development of antimicrobial resistance (AMR), which is defined as the evolution of resistant strains in response to a given set of antimicrobials (16).…”

The Efficacy and Safety of a Single Dose of Clindesse™ Vaginal Cream Versus a Seven‐Dose Regimen of Cleocin ® Vaginal Cream in Patients With Bacterial Vaginosis

“…While both oral and intravaginal administrations are effective, intravaginal medications may result in fewer of the adverse side effects associated with oral antibiotic therapy such as nausea, vomiting, and taste perversion [4,5]. In addition, patients treated with intravaginal therapies report increased treatment satisfaction compared with those treated with oral therapies [6].…”