Vaginal and reproductive system treatments using a bioadhesive polymer

Robinson, Joseph R.; Bologna, William J.

doi:10.1016/b978-0-444-82027-3.50013-4

Cited by 12 publications

(13 citation statements)

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“…120 A surface film of moisture consisting primarily of cervical mucus and of fluid exuded from the rich, vascular lamina propria covers the vaginal wall. 121 Volume, viscosity, and pH of the cervical mucus vary with age, and hormonal state of the patient that can influence the vaginal drug absorption. The permeability of the vaginal epithelium may vary during estrus or menstrual cycle.…”

Section: Vaginalmentioning

confidence: 99%

Bioadhesive‐Based Dosage Forms: The Next Generation

Lee

Park

Robinson

2000

Journal of Pharmaceutical Sciences

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464

152

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Section: Vaginalmentioning

confidence: 99%

Bioadhesive‐Based Dosage Forms: The Next Generation

Lee

Park

Robinson

2000

Journal of Pharmaceutical Sciences

Self Cite

464

152

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“…Obtained values indicate that the incorporation of the TVEO in the gel base did not influence significantly its activity. Nonetheless, it may be expected that this polycarbophil-based gel may be advantageous in vivo, due to its pH-buffering and moisturizing properties (Robinson & Bologna, 1994). Also, it seems possible to state that the amount of TVEO in the gel (1%, w/w) is enough to achieve significant amounts of this substance in the vagina, in order to manage VVC.…”

Section: Resultsmentioning

confidence: 99%

Antifungal activity of a gel containingThymus vulgarisessential oil againstCandidaspecies commonly involved in vulvovaginal candidosis

Neves

Pinto

Amaral

et al. 2009

Pharmaceutical Biology

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“…It act as permeability barrier for most of the drugs (Johnson et al, 1992). It can be exploited for bioadhesive delivery systems For pH-sensitive drugs and drugs which are weak electrolyte, alteration in vaginal pH may alter drug ionization, solubility, stability and subsequent drug release (Katz & Dunmire, 1993 (Robinson & Bologna, 1994). Lipophilic drugs of low molecular weight are readily absorbed then high molecular weight hydrophilic or lipophilic drugs.…”

Section: Pesseries and Suppositoriesmentioning

confidence: 99%

Advanced topical drug delivery system for the management of vaginal candidiasis

et al. 2014

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Vaginal candidiasis or vulvovaginal candidiasis (VC) is a common mucosal infection of vagina, mainly caused by Candida species. The major symptoms of VC are dyspareunia, pruritis, itching, soreness, vagina as well as vulvar erythema and edema. Most common risk factors that lead to the imbalance in the vaginal micro biota are the use of antibiotics, pregnancy, diabetes mellitus, immuno suppression as in AIDS or HIV patients, frequent sexual intercourse, spermicide and intra-uterine devices and vaginal douching. Various anti-fungal drugs are available for effective treatment of VC. Different conventional vaginal formulations (creams, gels, suppositories, powder, ointment, etc.) for VC are available today but have limited efficacy because of lesser residence time on vaginal epithelium due to self-cleansing action of vagina. So to overcome this problem, an extended and intimate contact with vaginal mucosa is desired; which can be accomplished by utilizing mucoadhesive polymers. Mucoadhesive polymers have an excellent binding capacity to mucosal tissues for considerable period of time. This unique property of these polymers significantly enhances retention time of different formulations on mucosal tissues. Currently, various novel formulations such as liposomes, nano-and microparticles, micro-emulsions, bio-adhesive gel and tablets are used to control and treat VC. In this review, we focused on current status of vaginal candidiasis, conventional and nanotechnology inspired formulation approaches.

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Vaginal and reproductive system treatments using a bioadhesive polymer

Cited by 12 publications

References 0 publications

Bioadhesive‐Based Dosage Forms: The Next Generation

Bioadhesive‐Based Dosage Forms: The Next Generation

Antifungal activity of a gel containingThymus vulgarisessential oil againstCandidaspecies commonly involved in vulvovaginal candidosis

Advanced topical drug delivery system for the management of vaginal candidiasis

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