Vaginal and Cervical Abnormalities Related to Prenatal Exposure to Diethylstilbestrol (DES)

Robboy, Stanley J.; Scully, Robert E.; Herbst, Arthur L.

doi:10.1007/978-1-4757-6143-6_4

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…Perhaps the most notorious example of this phenomenon is the link between in utero exposure to the super estrogen diethylstilbestrol (DES) and the later development of cervical and vaginal adenocarcinomas in girls (Robboy et al, 1975;recently reviewed in Swan, 2004). Permanent alterations in the structure of the tubular organs and ovaries have also been documented in adult ''DES daughters.''…”

Section: Maturation and Mechanisms Of Hormone Responsivenessmentioning

confidence: 97%

Evaluating rodent vaginal and uterine histology in toxicity studies

Li¹,

Davis

2007

Birth Defects Research Pt B

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Section: Maturation and Mechanisms Of Hormone Responsivenessmentioning

confidence: 97%

Evaluating rodent vaginal and uterine histology in toxicity studies

Li¹,

Davis

2007

Birth Defects Research Pt B

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“…Vaginal bleeding or unusual vaginal discharge before menarche is a clear indication for pelvic examination. T h e "Register for Clear-Cell Adenoma of the Genital Tract in Young Females" reports 15 cases of carcinoma in girls younger than 14 years, eight of whom had been exposed to DES (1,3).…”

Section: Discussionmentioning

confidence: 99%

“…Surgery and radiation have been used to treat clear-cell adenocarcinomas and both have resulted in eradication of the tumor in half of the cases (2)(3)(4). For early stage tumors, especially of the upper vagina and cervix, treatment by radical hysterectomy, vaginectomy and pelvic lymph node dissection with the replacement of the vagina with split-thickness skin graft has been successful in a high percentage of cases.…”

Section: Int J Gynaecol Obslel 16mentioning

confidence: 99%

Vaginal Adenocarcinoma in a Gravida with Prenatal DES Exposure

Castillo

Rubio

Farrell

1979

Intl J Gynecology & Obste

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The article presents a case of a young pregnant woman with vaginal carcinoma who had been exposed to diethylstilbestrol (DES) in utero. Surgical excision of the lesion was attempted but failed. Interstitial irradiation was then applied and proved successful. The patient's infant, as well as two subsequent children, were delivered by cesarean section after normal pregnancies. There was no evidence of metastatic disease or recurrence in 11½ years following the initial diagnosis. Since 1965, a rising incidence of vaginal adenocarcinoma in women who were exposed to (DES) in utero has been reported. These women should be examined regularly after menarche for prompt evaluation and treatment of precancerous lesions such as adenosis, cervical erosion or transverse ridges. Since most of these patients are young, a conservative treatment is recommended. Extensive surgery and pelvic irradiation is indicated, however, in the cases of widespread disease.

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Intramural papilloma of the vagina: Evidence of Müllerian histogenesis

Ulbright

Alexander

Kraus

1981

Cancer

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A papillary tumor occurred in the posterior-superior vaginal wall of a 5-year-old girl who was free of recurrence one year following surgical excision. The light microscopic features included papillae lined by eosinophilic cells with uniform, bland nuclei, solid areas of identical cells, and scattered glandular lumina which contained mucopolysaccharides. Foci of eosinophilic hyaline globules were another distinctive feature. Electron microscopy of the tumor demonstrated features associated with müllerian neoplasms including projecting microvilli, whorls of perinuclear cytoplasmic microfilaments, conspicuous lysosomes, squamous metaplasia, complex cytoplasmic interdigitations, and pseudoinclusions of "cytoplasmic" collagen. Previously described "mesonephric papillomas" of the vagina and cervix are compared with the tumor of the authors' patient. The previously described tumors share some histologic and clinical features, although they were superficial rather than intramural proliferations. The authors conclude that the ultrastructure, location, and documented presence of müllerian structures in the vagina favor a müllerian origin for this vaginal tumor. A number of other vaginal tumors that occur in children and young women show different light microscopic features.

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Vaginal and Cervical Abnormalities Related to Prenatal Exposure to Diethylstilbestrol (DES)

Cited by 5 publications

References 13 publications

Evaluating rodent vaginal and uterine histology in toxicity studies

Evaluating rodent vaginal and uterine histology in toxicity studies

Vaginal Adenocarcinoma in a Gravida with Prenatal DES Exposure

Intramural papilloma of the vagina: Evidence of Müllerian histogenesis

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