Vaginal adenosis in a patient on Tamoxifen therapy: a case report

Ganesan, Raji; Ferryman, S. R.; Waddell, Caroline C.

doi:10.1046/j.1365-2303.1999.00162.x

Cited by 14 publications

(5 citation statements)

References 8 publications

(7 reference statements)

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“…[1,4] Other sporadic case reports suggested alternative causes of vaginal adenosis, such as sulfonamide-induced Stevens-Johnson syndrome, [5] carbon dioxide laser treatment, 5-fluorouracil therapy, [6] and tamoxifen uterine-exposure. [7] However, the low incidence rate hindered the study of the etiology of vaginal adenosis. Even if the pathogenesis of vaginal adenosis is still not completely understood, in the cases of adenosis after vaginal inflammation, it is suggested that adenosis develops as a metaplastic process similar to other well-known types of metaplasia that occur as a result of noxious stimuli in other parts of the body.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic features and outcomes of primary vaginal adenosis as a dermatologic and gynecologic burden

Han¹,

Jin²,

Li³

et al. 2018

Medicine

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In the recent 20 years, primary vaginal adenosis is extremely rare and the data of clinical presentations, management, and outcome have not been studied systematically.In this retrospective study, women with vaginal adenosis between January 1997 and June 2017 were identified from the hospital's medical records. Data on patient age, history, symptoms, mass location, size, diagnosis, complications, treatment, and recurrence were analyzed by SPSS 20.0.Twenty women were histopathologically diagnosed as having vaginal adenosis (mean age, 37.9 ± 10.6 years). All patients denied utero exposure. The most common symptom was vaginal pain or abnormal bleeding. For all patients, the local vaginal lesions were surgically excised. Seven patients had complications with endometriosis. 15 patients lived without recurrence, and 1 patient underwent postoperative local recurrence after 81 months. Primary vaginal squamous cell carcinoma in another patient was confirmed to arise from adenosis; she survived with disease. The remaining 3 patients developed carcinoma of different types in varied periods of a disease-free state (5 months, 30 months, and 23 years, respectively); 1 patient died of progressive disease, and 2 patients survived with disease.Primary vaginal adenosis is a spontaneous lesion with a propensity for late canceration. Local lesion resection is the primary treatment.

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Section: Discussionmentioning

confidence: 99%

Clinicopathologic features and outcomes of primary vaginal adenosis as a dermatologic and gynecologic burden

Han¹,

Jin²,

Li³

et al. 2018

Medicine

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“…In most instances, the diagnosis is not made clinically; the prolapsed tube is usually interpreted as proliferative vault granulation tissue 4. Other differential diagnoses of glandular lesions occurring at the vaginal cuff after hysterectomy include vaginal adenosis,11 endometriosis,2 cysts of mesonephric or paramesonephric ducts10, 12 and primary, recurrent and metastatic adenocarcinoma 2, 10, 11…”

Section: Discussionmentioning

confidence: 99%

“…Vaginal adenosis may be induced by DES exposure congenitally or acquired after treatment by radiotherapy or by the late effects of tamoxifen 11. This is a metaplastic change in the vaginal epithelium in which there is replacement of vaginal squamous epithelium by endocervical‐type epithelium.…”

Section: Discussionmentioning

confidence: 99%

“…Malignant glandular lesions of the vagina include primary, recurrent and metastatic adenocarcinoma, the history, clinical and radiological examinations are important. The cytology shows malignant features 11. Large malignant cells with vacuolated cytoplasm, large hyperchromatic nuclei and prominent nucleoli are found in cervico‐vaginal smears both singly and in papillary clusters 13…”

Section: Discussionmentioning

confidence: 99%

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Prolapsed fallopian tube: Cytological findings in a ThinPrep liquid based cytology vaginal vault sample

Nasir

Desai

Marshall

et al. 2011

Diagnostic Cytopathology

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Fallopian tube prolapse through the vaginal vault after hysterectomy is a rare complication. The clinical diagnosis is difficult and the patient may undergo unnecessary treatment. A cytological diagnosis of tubal prolapse is rare. There are very few descriptions of the cytological appearances of prolapsed fallopian tube and to our knowledge, they have not been described in liquid based cytology preparations. The presence of classic columnar cells with cilia and sheets of cells with small granular uniform nuclei in an orderly arrangement are the diagnostic appearances of cells originating from the fallopian tube. We describe a case in which the cells had undergone squamous metaplasia with nuclear enlargement and increased nuclear to cytoplasmic ratios corresponding to reactive atypia but with fine and evenly distributed chromatin and smooth nuclear contours, which indicated their benign nature. In addition, in this case intracytoplasmic polymorphs and associated extracellular infiltrates of inflammatory cells are noted. The description of this case may help others to consider a cytological diagnosis of prolapsed fallopian tube, thus preventing repeated cauterisations of vault granulation tissue on one hand, and possibly excessive surgical treatment of a mistaken malignant lesion on the other.

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“…Teratogenic studies in animals done for tamoxifen showed results similar to those recorded after administration of DES under similar conditions. Caution in the administration of tamoxifen to women at risk of pregnancy and careful follow-up of children born to women who received tamoxifen are recommended [12,13].…”

Section: Discussionmentioning

confidence: 99%

Vaginal Adenosis in a Non-Diethylstilbestrol-Exposed 6-Year-Old Patient

Accetta

Rivoire²,

Monego³

et al. 2001

Gynecol Obstet Invest

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Vaginal adenosis is rare, and it is defined as the presence of metaplastic cervical or endometrial epithelium within the vaginal wall. It is associated with in utero exposition to diethylstilbestrol and a high risk of vaginal carcinomas. A case of vaginal adenosis arising in a non-diethylstilbestrol-exposed 6-year-old patient is presented. Few cases have been described in children and adolescents, and since the withdrawal of diethylstilbestrol from the market, this condition is rarely described in the medical literature. However, it should be considered as a possible diagnosis in girls with persistent vaginal discharge.

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Vaginal adenosis in a patient on Tamoxifen therapy: a case report

Cited by 14 publications

References 8 publications

Clinicopathologic features and outcomes of primary vaginal adenosis as a dermatologic and gynecologic burden

Clinicopathologic features and outcomes of primary vaginal adenosis as a dermatologic and gynecologic burden

Prolapsed fallopian tube: Cytological findings in a ThinPrep liquid based cytology vaginal vault sample

Vaginal Adenosis in a Non-Diethylstilbestrol-Exposed 6-Year-Old Patient

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