Vagal stimulation, gastrin release, and acid secretion in anesthetized dogs

Lanciault, G.; Bonoma, C.; Fp, Brooks

doi:10.1152/ajplegacy.1973.225.3.546

Cited by 23 publications

(9 citation statements)

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“…Recent studies have demonstrated that electrical stimulation ofthe vagus nerve elicits insulin and/or glucagon release (3)(4)(5). It has been shown also in in vivo studies that electrical vagal stimulation causes an increase in the blood glucose level (6,7) and enhances the release of gastrin (8) and vasoactive intestinal polypeptide (VIP)' (9). These extrapancreatic factors are known to influence pancreatic endocrine functions and make it difficult to evaluate the direct vagal effect on the pancreas although previous studies elaborated procedures to obviate indirect effect as much as possible (10)(11)(12).…”

Section: Introductionmentioning

confidence: 98%

Vagal regulation of insulin, glucagon, and somatostatin secretion in vitro in the rat.

Nishi¹,

Seino²,

Ishida³

et al. 1987

J. Clin. Invest.

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Using a new in vitro procedure of the isolated perfused rat pancreas with vagal innervation, electrical vagal stimulation produced an increase in both insulin and glucagon secretion in proportion to the pulse frequency, but an inhibition in somatostatin release. When atropine was infused, both insulin and glucagon responses to vagal stimulation were partially suppressed, whereas somatostatin release was enhanced. In the presence of hexamethonium, vagal stimulation failed to affect insulin, glucagon, or somatostatin secretion. Propranolol partially blocked both insulin and glucagon responses but did not influence somatostatin response. Phentolamine had no significant effect on release of hormones. Simultaneous administration of propranolol and phentolamine tended to inhibit both insulin and glucagon responses to vagal stimulation. These findings suggest that not only a cholinergic but also a noncholinergic neuron may be involved in vagal regulation of pancreatic hormone secretion and that these neurons may be under the control of preganglionic vagal fibers via nicotinic receptors.

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Section: Introductionmentioning

confidence: 98%

Vagal regulation of insulin, glucagon, and somatostatin secretion in vitro in the rat.

Nishi¹,

Seino²,

Ishida³

et al. 1987

J. Clin. Invest.

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“…In this preparation, in which gastrin release was not inhibited by acid bathing the antrum, vagal stimulation produced a small but significant secretion of acid from the Heidenhain pouch [9]. More recent studies using the gastrin radio immunoassay confirmed that gastrin can be released during vagal stimula tion by insulin hypoglycemia [4], by electric current directly applied to the vagus nerve [6], and by sham feeding [8].…”

Section: Discussionmentioning

confidence: 99%

“…There is abundant evidence that vagal nerve stimulation releases gastrin in experimental animals and man [1,3,4,6,[8][9][10]. However, the importance of gastrin release for the acid secretory response to vagal stimulation is not clear.…”

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confidence: 99%

Dose Dependance of Insulin-Stimulated Gastrin Release in the Dog

Hughes¹,

Green²

1974

Digestion

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The relations among insulin dose, gastric acid secretion and serum gastrin levels were examined in dogs with chronic gastric fistulae. Intravenous insulin doses of 0.125, 0.25, 0.50, and 1.0 U/kg were studied. Although the fall in glucose measured at 30 min was similar after all doses, gastrin levels rose significantly only after the two highest doses. In spite of the difference in gastrin levels there was no significant difference in peak acid outputs after the four doses.

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“…The abundant literature on brain structures and pathways possi bly controlling gastric acid secretion contrasts with the pau city of information regarding gastrin secretion [8]. The only reports published so far demonstrated that midcollicular decerebration in cats or dogs increased basal and vagally stimulated portal gastrin levels [17,20] and that brain injury in patients is associated with elevated plasma gastrin [3]. To what extent LH cell bodies, projections, or fibers of passage are involved in specifically mediating the gastrin-releasing action of intracisternal bombesin in rats or represent a gene ral pathway for modulation of gastrin secretion in response to various central nervous system-mediated physiological or pharmacological stimuli needs to be further investigated.…”

Section: Discussionmentioning

confidence: 99%

Lateral Hypothalamic Mediation of Hypergastrinemia Induced by Intracisternal Bombesin

Taché¹,

Grijalva²,

Gunion³

et al. 1984

Neuroendocrinology

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Electrolytic lesions of the lateral hypothalamus (LH), but not of the lateral thalamus, prevented the elevation of serum gastrin induced by intracisternal injection of bombesin in rats. Knife cuts through the lateral or the posterior LH border largely abolished the rise in circulating gastrin induced by intracisternal bombesin. Cuts through the medial LH border partly inhibited the response, whereas cuts through the anterior LH border did not modify peptide action. None of the transections altered basal gastrin levels nor the rise in gastric pH and inhibition of gastric acid output induced by intracisternal bombesin. LH lesions did not modify the rise in serum gastrin induced by intravenous bombesin. These results demonstrate that the gastrin-releasing effect of intracisternal bombesin requires the integrity of fibers crossing the posterior, lateral, and medial borders of the LH and is independent of changes in gastric pH. The LH area is not itself necessary for the expression of the inhibitory action of bombesin on gastric acid secretion.

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Vagal stimulation, gastrin release, and acid secretion in anesthetized dogs

Cited by 23 publications

References 0 publications

Vagal regulation of insulin, glucagon, and somatostatin secretion in vitro in the rat.

Vagal regulation of insulin, glucagon, and somatostatin secretion in vitro in the rat.

Dose Dependance of Insulin-Stimulated Gastrin Release in the Dog

Lateral Hypothalamic Mediation of Hypergastrinemia Induced by Intracisternal Bombesin

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