Vagal Paraganglioma: Surgical Removal with Superior Laryngeal Nerve Preservation

Kotsis, Thomas; Christoforou, Panagitsa

doi:10.5758/vsi.2019.35.2.105

Cited by 6 publications

(8 citation statements)

References 18 publications

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“…CT, CT angiography, MRI, and PET/CT have been found useful for the diagnosis of the disease [ 1 , 2 ]. Specifically, Ga-labelled somatostatin agonist PET is favored regardless of the patient's genetic background [ 13 ]. Fine-needle biopsy plays an elusive role in the diagnosis of paragangliomas, and cytology is non-diagnostic most of the time [ 2 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Conventionally, apart from radionuclide therapy administration of alkylating agents or tyrosine kinase inhibitors (13), the nonsurgical treatment of paragangliomas entails recent methods of radiotherapy, which involve single-fraction gamma knife radiosurgery and CyberKnife (Accuray Incorporated, Sunnyvale, CA) radiosurgery [8,9,13].…”

Section: Figure 4: Nests Of Cells Areas Of Hemorrhage and Cystic Spacesmentioning

confidence: 99%

“…Paragangliomas are highly vascularized tumors that emanate from the paraganglia of neural crest cells and appear commonly in the head and neck region; they are classified as symptomatic or asymptomatic based on their ability of endogenous hormone secretion [1,2]. They usually occur in the carotid body [3][4][5][6][7], jugulotympanic area [8][9][10][11][12], and vagal paraganglia [4,13]; they are also found in other regions in the head and neck such as the thyroid [2,3,6,10], nasal cavity [11], endolarynx [12], and supraclavicular fossa [1].…”

Section: Introductionmentioning

confidence: 99%

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A Paraganglioma in the Right Supraclavicular Fossa: Mistaken for a Thyroid Mass

Νικολόπουλος¹,

Ploumidou²,

Sourla³

et al. 2021

Cureus

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Paragangliomas are rare lesions of the endocrine system that can be treated either by embolization preoperatively followed by surgical excision or by surgical excision or radiotherapy. In this report, we present an extremely rare location of a nonfunctional paraganglioma in the head and neck region, located in the right supraclavicular fossa, which was misdiagnosed as a thyroid tumor, in a 72-year-old female patient. Imaging revealed a 2.5 × 4.5 × 2 cm well-defined vascularized mass. Fine-needle aspiration (FNA) on the tumor was not diagnostic initially; however, a third attempt revealed thyroid cells suggesting the existence of an ectopic thyroid tumor. FNA was additionally performed on the right thyroid lobe, revealing atypical follicular colloid cells of the Bethesda 3 category. Therefore, the excision of the ectopic thyroid tumor along with right lobectomy was planned. No embolization was initiated preoperatively in this case. Histopathology revealed that the supraclavicular mass was a paraganglioma. Paragangliomas supplied by the subclavian, innominate, and common carotid artery are rarely reported, and to our knowledge, this is the third case to be reported worldwide.

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Section: Discussionmentioning

confidence: 99%

Section: Figure 4: Nests Of Cells Areas Of Hemorrhage and Cystic Spacesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Paraganglioma in the Right Supraclavicular Fossa: Mistaken for a Thyroid Mass

Νικολόπουλος¹,

Ploumidou²,

Sourla³

et al. 2021

Cureus

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“…Paragangliomas(PGLs) are neoplasms of neural crest origin.PGLs are rare in head and neck region.Even thoughdifficult to estimate the exact incidence of head and neck PGLs," they represent <0.5% of all head and neck tumours. They couldbe originated from the carotid body, tympanic, jugular or vagal" paraganglia 1 .…”

Section: Introductionmentioning

confidence: 99%

Laryngeal paraganglioma

Balasubramaniam

Thirumaran

2022

Ceylon J Otolaryngology

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Paragangliomas of the head and neck are rare especially in larynx. A 36 year old female patient presented with a history of progressive voice change and difficulty of swallowing for 6 months. During endoscopic examinationsmooth surfaced mass on Left supraglottic region, was noted. Tumour was excised through transcervical excision. Histology and immunohistochemistry of the tumour revealed that, it was paraganglioma.

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“…They range from pulsatile tinnitus/ringing in the ear to deficits of cranial nerves (such as hoarseness and dysphagia) and intracranial extension associated with an increased risk of death [ 5 ]. VPGL accounts for approximately 13% of all head and neck paragangliomas (HNPGLs) and occurs more frequently in women [ 6 , 7 ]. Surgical resection is a primary treatment for VPGL, whereas radiation therapy is used in case of malignant and unresectable tumors [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Mutation profiling in eight cases of vagal paragangliomas

et al. 2020

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Background Vagal paragangliomas (VPGLs) belong to a group of rare head and neck neuroendocrine tumors. VPGLs arise from the vagus nerve and are less common than carotid paragangliomas. Both diagnostics and therapy of the tumors raise significant challenges. Besides, the genetic and molecular mechanisms behind VPGL pathogenesis are poorly understood. Methods The collection of VPGLs obtained from 8 patients of Russian population was used in the study. Exome library preparation and high-throughput sequencing of VPGLs were performed using an Illumina technology. Results Based on exome analysis, we identified pathogenic/likely pathogenic variants of the SDHx genes, frequently mutated in paragangliomas/pheochromocytomas. SDHB variants were found in three patients, whereas SDHD was mutated in two cases. Moreover, likely pathogenic missense variants were also detected in SDHAF3 and SDHAF4 genes encoding for assembly factors for the succinate dehydrogenase (SDH) complex. In a patient, we found a novel variant of the IDH2 gene that was predicted as pathogenic by a series of algorithms used (such as SIFT, PolyPhen2, FATHMM, MutationTaster, and LRT). Additionally, pathogenic/likely pathogenic variants were determined for several genes, including novel genes and some genes previously reported as associated with different types of tumors. Conclusions Results indicate a high heterogeneity among VPGLs, however, it seems that driver events in most cases are associated with mutations in the SDHx genes and SDH assembly factor-coding genes that lead to disruptions in the SDH complex.

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Vagal Paraganglioma: Surgical Removal with Superior Laryngeal Nerve Preservation

Cited by 6 publications

References 18 publications

A Paraganglioma in the Right Supraclavicular Fossa: Mistaken for a Thyroid Mass

A Paraganglioma in the Right Supraclavicular Fossa: Mistaken for a Thyroid Mass

Laryngeal paraganglioma

Mutation profiling in eight cases of vagal paragangliomas

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