Vagal Paraganglioma

Zanoletti, Elisabetta; Mazzoni, Antonio

doi:10.1055/s-2006-949519

Cited by 53 publications

(45 citation statements)

References 15 publications

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“…Familial VP may have a more aggressive growth pattern than a nonfamilial one [Bradshaw and Jansen, 2005]. Due to the high probability of a familial form of the disease [Spector et al, 1976;Zanoletti and Mazzoni, 2006], a detailed family history has to be obtained. If positive, genetic testing including VHL, RET, NF1, SDHD, SDHB and SDHC genes [Klein et al, 1993] is suggested for the patient and first-degree relatives.…”

Section: Discussionmentioning

confidence: 99%

“…Most authors [Biller et al, 1989;Browne et al, 1993;Miller et al, 2000;Netterville et al, 1998;Urquhart et al, 1994;Zanoletti and Mazzoni, 2006] except for van der Mey et al [1992] and Bradshaw and Jansen [2005] advocated surgical resection as the mainstay of treatment for VP. In a small number of cases, radiotherapy was performed.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Among these series, stenting was utilized only in our institute. Netterville et al [1998] and Zanoletti and Mazzoni [2006] reported a combined total of 3 cases of cerebral vascular accidents ( table 6 ). Table 8 shows a summary of the management of ICA and its complications, comparing reported cases from 8 published series and our present series.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Vagal paragangliomas (VP) are rare neuroendocrine neoplasms that may arise from paraganglia along the course of the vagus nerve and account for approximately 5% of all head and neck paragangliomas, with an annual incidence of 1 per 100000 population [Eriksen et al, 1991;Lawson, 1980;Netterville et al, 1998;Persky et al, 2004;Zanoletti and Mazzoni, 2006]. VP generally present as a slow-growing neck mass which may protrude medially with deviation of the oropharyngeal structures.…”

Section: Introductionmentioning

confidence: 99%

“…Because the tumor arises from the paraganglionic tissue within the perineurium of the vagus nerve, surgical resection invariably results in complete vagal paralysis [Arts and Fagan, 1991;Biller et al, 1989;Bradshaw and Jansen, 2005;Eriksen et al, 1991;Hirsch et al, 1982;Moore et al, 1986;Urquhart et al, 1994;van der Mey et al, 1992;Zanoletti and Mazzoni, 2006]. The morbidity associated with resection, especially of the remaining cranial nerves, is dependent on the tumor's size and superior extent.…”

Section: Introductionmentioning

confidence: 99%

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Management of Vagal Paragangliomas Including Application of Internal Carotid Artery Stenting

et al. 2011

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Background: The primary treatment of vagal paraganglioma (VP) includes ‘wait and scan’, surgery and radiotherapy. Objectives: To present the clinical findings, surgical treatment including application of internal carotid artery (ICA) stenting to facilitate surgery, and complications, as well as to review the literature and to discuss the decision-making process in the management of VP cases based on our experience and the literature. Design: A retrospective case review of 22 cases with VP. Setting: Quaternary neurotologic and skull base referral center. Material and Methods: The retrospective chart review identified 22 patients presenting with VP. Our indication for surgery was VP in younger patients, irrespective of the existence of vocal cord paralysis. Preoperative endovascular management of the ICA included permanent balloon occlusion (PBO) and stenting. The transcervical approach and the infratemporal fossa approach type A (ITFA) were used. Results: Fifteen cases had multicentric paragangliomas, 5 cases bilateral tumors, 3 cases a genetic mutation, and 2 cases a positive family history. The most common symptoms were hoarseness, tinnitus and hearing loss. The surgical approaches commonly employed for excision were the transcervical approach (9 cases) and the ITFA (12 cases), whereas 1 case did not have surgery. Three cases had PBO and 7 had intracarotid stent insertion. Gross total removal was achieved in 19 cases, and 1 case had a recurrence. Eighteen cases had no dysphagia or were well compensated after surgery. There were no significant complications noted in our series. Conclusions: In younger patients with VP, surgery should be recommended. The proper preoperative endovascular intervention and surgical approach facilitates gross total tumor removal. In the management of bilateral or familial paragangliomas, careful and appropriate decision making is essential.

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Section: Discussionmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Management of Vagal Paragangliomas Including Application of Internal Carotid Artery Stenting

et al. 2011

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Management of head and neck paragangliomas: Review of 120 patients

2009

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According to our experience, the treatment of PGL must be individualized, taking into account the patient's age, medical condition, tumor site and size, multiple occurrences, and preexisting cranial nerve deficits. Tumor control is high whether treatment is by surgery or radiotherapy. Patients with solitary lesions whose disease is potentially resectable with acceptable morbidity are better treated surgically.

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