Vagal Nerve Stimulation: A Potentially Useful Adjuvant to Treatment of Sepsis

Yang, Gui-Zhen; Xue, Fu‐Shan; Sun, Chao; Liao, Xu; Liu, Jianhua

doi:10.24015/japm.2017.0012

Cited by 3 publications

(3 citation statements)

References 36 publications

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“…These results spawned a series of studies in patients with depression which led, in 2005, to FDA approval of iVNS for the treatment of pharmacoresistant depression (Cristancho et al, 2011 ; Desbeaumes Jodoin et al, 2018 ). More recently, iVNS has been evaluated as treatment for a diverse array of disorders including heart failure (Ferrari et al, 2011 ; Wang et al, 2015a ), rheumatoid arthritis (Koopman et al, 2016 ), inflammatory bowel disease (Levine et al, 2014 ), sepsis (Wang et al, 2016 ; Yang et al, 2017 ), and chronic pain (Lange et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020)

Farmer

Strzelczyk

Finisguerra

et al. 2021

Front. Hum. Neurosci.

153

137

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Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation (tVNS) across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation(VNS) and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice.

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Section: Introductionmentioning

confidence: 99%

International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020)

Farmer

Strzelczyk

Finisguerra

et al. 2021

Front. Hum. Neurosci.

153

137

View full text Add to dashboard Cite

show abstract

“…We suggest that in order to reduce the chances of inflammatory conditions in the wake of surgery, it might be worthwhile to provide some activities that increase the vagal activity prior to the surgery (“pre-habilitation”). This would increase the patient’s vagal inflammatory resistance allowing him/her to cope with the event of surgery and the associated stress more effectively (Geiss et al, 2005; Laitio et al, 2007; Mazzeo et al, 2011; Bravi et al, 2012; Bohanon et al, 2015; Ernst et al, 2017; Reimer et al, 2017; Yang et al, 2018). An additional argument in favor of this conclusion comes from our observation that patients with strong pre-surgery values make the best use of the rehabilitation in improving their vagal activity.…”

Section: Discussionmentioning

confidence: 99%

Dynamics of Vagal Activity Due to Surgery and Subsequent Rehabilitation

Grote

Levnajić

Puff³

et al. 2019

Front. Neurosci.

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BackgroundVagal activity is critical for maintaining key body functions, including the stability of inflammatory control. Its weakening, such as in the aftermatch of a surgery, leaves the body vulnerable to diverse inflammatory conditions, including sepsis.MethodsVagal activity can be measured by the cardiorespiratory interaction known as respiratory sinus arrhythmia or high-frequency heart-rate variability (HRV). We examined the vagal dynamics before, during and after an orthopedic surgery. 39 patients had their HRV measured around the period of operation and during subsequent rehabilitation. Measurements were done during 24 h circadian cycles on ten specific days. For each patient, the circadian vagal activity was calculated from HRV data.ResultsOur results confirm the deteriorating effect of surgery on vagal activity. Patients with stronger pre-operative vagal activity suffer greater vagal withdrawal during the peri-operative phase, but benefit from stronger improvements during post-operative period, especially during the night. Rehabilitation seems not only to efficiently restore the vagal activity to pre-operative level, but in some cases to actually improve it.DiscussionOur findings indicate that orthopedic rehabilitation has the potential to strengthen the vagal activity and hence boost inflammatory control. We conclude that providing a patient with a vagal reinforcement procedure prior to the surgery (“pre-habilitation”) might be a beneficial strategy against post-operative complications. The study also shows the clinical usefulness of quantifying the cardiorespiratory interactions.

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“…Following the number of further clinical trials, observational studies and subsequent analysis led to the approval of VNS by the FDA in 2005 to treat pharmaco-resistant depression [129,130]. More recently, VNS has been evaluated and suggested as an alternative for treating a diverse array of disorders, including sepsis [131,132], heart failure [121,133], bowel disease [134], chronic pain [135], and rheumatoid arthritis inflammatory [136]. ElectroCore (Rockaway, NJ, USA) introduced GammaCore (nVNS), a noninvasive VNS, also referred to as the transcutaneous VNS (taVNS), is the most widely available device [137].…”

Section: Vagus Nerve Stimulationmentioning

confidence: 99%

New Era of Electroceuticals: Clinically Driven Smart Implantable Electronic Devices Moving towards Precision Therapy

Magisetty

Park

2022

Micromachines

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In the name of electroceuticals, bioelectronic devices have transformed and become essential for dealing with all physiological responses. This significant advancement is attributable to its interdisciplinary nature from engineering and sciences and also the progress in micro and nanotechnologies. Undoubtedly, in the future, bioelectronics would lead in such a way that diagnosing and treating patients’ diseases is more efficient. In this context, we have reviewed the current advancement of implantable medical electronics (electroceuticals) with their immense potential advantages. Specifically, the article discusses pacemakers, neural stimulation, artificial retinae, and vagus nerve stimulation, their micro/nanoscale features, and material aspects as value addition. Over the past years, most researchers have only focused on the electroceuticals metamorphically transforming from a concept to a device stage to positively impact the therapeutic outcomes. Herein, the article discusses the smart implants’ development challenges and opportunities, electromagnetic field effects, and their potential consequences, which will be useful for developing a reliable and qualified smart electroceutical implant for targeted clinical use. Finally, this review article highlights the importance of wirelessly supplying the necessary power and wirelessly triggering functional electronic circuits with ultra-low power consumption and multi-functional advantages such as monitoring and treating the disease in real-time.

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Vagal Nerve Stimulation: A Potentially Useful Adjuvant to Treatment of Sepsis

Cited by 3 publications

References 36 publications

International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020)

International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020)

Dynamics of Vagal Activity Due to Surgery and Subsequent Rehabilitation

New Era of Electroceuticals: Clinically Driven Smart Implantable Electronic Devices Moving towards Precision Therapy

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