Vagal Nerve Control of Appetite, Energy, Regulation, and Body Weight

Kukreja, Sachin; Knudson, Mark B.; Tweden, Katherine S.; Aspinwall, Kelly; Shikora, Scott A.

doi:10.1007/978-3-319-93545-4_15

Cited by 1 publication

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, evidence suggests that the vagus nerve plays an important role in increasing ghrelin levels during fasting, but is not involved in the modulation of postprandial ghrelin levels. Vagotomized individuals are known to present reduced appetite and weight loss 61 . In this regard, infusion of ghrelin did not stimulate food intake in individuals that underwent vagotomy, although the stimulation of growth hormone secretion by ghrelin was still observed 62 .…”

Section: Neural Stimulation Of Ghrelin Secretion During Fastingmentioning

confidence: 90%

“…Therefore, it appears an intact vagus nerve is necessary for the orexigenic effect of ghrelin, which is plausibly related to the weight loss reported in vagotomized humans. Considering the important role of the vagus nerve in energy intake, 61 the modulation of vagal nerve signalling has been investigated as a potential obesity treatment, with electrical vagal nerve stimulation (VNS) and vagal nerve blockade (vBloc) shown to induce weight loss 61,63 . However, the mechanisms responsible for these effects remain unclear and further studies are necessary to explain these paradoxical results and their relation to changes in the ghrelin system.…”

Section: Neural Stimulation Of Ghrelin Secretion During Fastingmentioning

confidence: 99%

See 1 more Smart Citation

The regulation of gastric ghrelin secretion

Nunez‐Salces

Feinle‐Bisset

et al. 2020

Acta Physiologica

View full text Add to dashboard Cite

Ghrelin is a gastric hormone with multiple physiological functions, including the stimulation of food intake and adiposity. It is well established that circulating ghrelin levels are closely associated with feeding patterns, rising strongly before a meal and lowering upon food intake. However, the mechanisms underlying the modulation of ghrelin secretion are not fully understood. The purpose of this review is to discuss current knowledge on the circadian oscillation of circulating ghrelin levels, the neural mechanisms stimulating fasting ghrelin levels and peripheral mechanisms modulating postprandial ghrelin levels. Furthermore, the therapeutic potential of targeting the ghrelin pathway is discussed in the context of the treatment of various metabolic disorders, including obesity, type 2 diabetes, diabetic gastroparesis and Prader‐Willi syndrome. Moreover, eating disorders including anorexia nervosa, bulimia nervosa and binge‐eating disorder are also discussed.

show abstract

Section: Neural Stimulation Of Ghrelin Secretion During Fastingmentioning

confidence: 90%

Section: Neural Stimulation Of Ghrelin Secretion During Fastingmentioning

confidence: 99%