Vagal damage enhances polyneuropathy pain: Additive effect of two algogenic mechanisms

Weissman-Fogel, Irit; Dashkovsky, Arkadi; Rogowski, Zeev; Yarnitsky, David

doi:10.1016/j.pain.2007.11.017

Cited by 24 publications

(19 citation statements)

References 46 publications

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“…Sex differences in DNIC have been evaluated in a number of studies (Table 11). Approximately half (6/13, 46%) of the studies suggest that DNIC is more pronounced in males than females, based on psychophysical147,165,321,384,438 and neurophysiological371 responses. In contrast, five studies have found that males and females inhibit pain equally during exposure to a conditioning stimulus 20,106,137,268,319,411.…”

Section: Sex Differences In Responses To Experimental Painmentioning

confidence: 99%

Sex, Gender, and Pain: A Review of Recent Clinical and Experimental Findings

Fillingim

King

Ribeiro-Dasilva

et al. 2009

The Journal of Pain

2,126

154

1,692

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Sex-related influences on pain and analgesia have become a topic of tremendous scientific and clinical interest, especially in the last 10 to 15 years. Members of our research group published reviews of this literature more than a decade ago, and the intervening time period has witnessed robust growth in research regarding sex, gender, and pain. Therefore, it seems timely to revisit this literature. Abundant evidence from recent epidemiologic studies clearly demonstrates that women are at substantially greater risk for many clinical pain conditions, and there is some suggestion that postoperative and procedural pain may be more severe among women than men. Consistent with our previous reviews, current human findings regarding sex differences in experimental pain indicate greater pain sensitivity among females compared with males for most pain modalities, including more recently implemented clinically relevant pain models such as temporal summation of pain and intramuscular injection of algesic substances. The evidence regarding sex differences in laboratory measures of endogenous pain modulation is mixed, as are findings from studies using functional brain imaging to ascertain sex differences in pain-related cerebral activation. Also inconsistent are findings regarding sex differences in responses to pharmacologic and non-pharmacologic pain treatments. The article concludes with a discussion of potential biopsychosocial mechanisms that may underlie sex differences in pain, and considerations for future research are discussed.Perspective-This article reviews the recent literature regarding sex, gender, and pain. The growing body of evidence that has accumulated in the past 10 to 15 years continues to indicate substantial sex differences in clinical and experimental pain responses, and some evidence suggests that pain treatment responses may differ for women versus men.Research regarding sex and gender, differences in pain has increased substantially in recent years. As Fig 1 depicts, publications regarding sex, gender, and pain have increased at a much greater rate over the past 25 to 30 years relative to the pain field in general. In particular, a dramatic increase in publications began in the mid-1990s, which may be attributable to several influential review articles along with other events occurring in the 1990s that drew considerable attention to the topic. In 1992, an important publication by Karen Berkley 32 highlighted the importance of sex-related issues in neuroscience research. This brief paper included a survey of 100 articles in reputable neuroscience journals, which found that 45% of the articles failed to report the sex of their subjects, and the author stated "… the differences between females and males, which we all know to be important, can and should be exploited in scientific research." Shortly thereafter, an editorial appeared in The Journal of Pain, which encouraged Address reprint requests to Dr Roger B. Fillingim, University of Florida, 1329 SW 16th Street, Suite 5180, PO Box 103628...

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Section: Sex Differences In Responses To Experimental Painmentioning

confidence: 99%

Sex, Gender, and Pain: A Review of Recent Clinical and Experimental Findings

Fillingim

King

Ribeiro-Dasilva

et al. 2009

The Journal of Pain

2,126

154

1,692

View full text Add to dashboard Cite

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“…The same procedure was repeated thrice, with a gap of 5 minutes and the total numbers of withdrawals (in three tests) were added to obtain a single cumulative score of mechanical dynamic allodynia with a minimum value of 0 and maximum of 15. 23,24 Biochemical estimations…”

Section: Mechanical Dynamic Allodynia (Paint-brush Test)mentioning

confidence: 99%

Ameliorative potential of ferulic acid in vincristine-induced painful neuropathy in rats: An evidence of behavioral and biochemical examination

Vashistha

Sharma

Jain

2016

Nutritional Neuroscience

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The present study was designed to investigate the effect of ferulic acid (FA) in vincristine-induced neuropathic pain in rats. Vincristine (50 µg/kg, i.p. for 10 consecutive days) was administered to induce painful neuropathy in rats. Various pain sensitive tests, viz., pinprick, hot plate, paint-brush, and acetone test were performed on different days (1, 6, 14, and 21) to assess the degree of mechanical hyperalgesia, heat hyperalgesia, mechanical dynamic allodynia, and cold allodynia, respectively. The electrophysiological and histopathological evaluations were also investigated. The tissue thiobarbituric acid reactive species (TBARS), reduced glutathione (GSH), myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-10 (IL-10), and total calcium were measured as the markers of inflammation and oxidative stress. FA (50 and 100 mg/kg, i.p.) and gabapentin (10 mg/kg, p.o.) were administered for 11 days. Administration of FA attenuated the vincristine-induced behavioral alteration along with electrophysiological and histopathological changes significantly (P < 0.05). FA also attenuated the vincristine-induced oxidative stress (TBARS, GSH, and total calcium levels) and inflammation (MPO, TNF-alpha, IL-6, and IL-10). It may be concluded that FA has ameliorative potential in mitigation of the painful states associated with vincristine-induced painful neuropathy that may further be attributed to anti-inflammatory actions with subsequent reduction in oxidative stress.

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“…The stimulus was applied five times with a 5 s interval and the numbers of withdrawals were noted (between 0 and 5). The same procedure was repeated twice, with a gap of five minutes and the total number of withdrawals (in three tests) were added to obtain a single cumulative score of mechanical dynamic allodynia with a minimum value of 0 and maximum of 15 (Thibault et al, 2008;Weissman-Fogel et al, 2008).…”

Section: Mechanical Dynamic Allodynia (Paint-brush Test)mentioning

confidence: 99%