Vagal control of migrating motor complex in the dog

Hall, Karen E.; El-Sharkawy, T. Y.; Diamant, Nicholas E.

doi:10.1152/ajpgi.1982.243.4.g276

Cited by 72 publications

(63 citation statements)

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“…A well known example is the migrating motor complex in the small intestine which is a rhythmic motor pattern that is orchestrated by the ENS with input from the vagus; but the motor activity during phase III is driven by the slow wave activity, giving the individual contractions their frequency and propagation characteristics. 47 In the mouse colon, excitatory nerves act on ICC-MP to evoke rhythmic depolarizations that underlie the propagating motor complexes. 16,48 With respect to the slow propagating segmental contractions in the rat colon, further research has to reveal whether it is similar to the migrating motor complexes or the segmentation motor pattern in the intestine.…”

Section: Discussionmentioning

confidence: 99%

Neurotensin Changes Propulsive Activity into a Segmental Motor Pattern in the Rat Colon

Chen

Yang

et al. 2016

J Neurogastroenterol Motil

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Background/AimsNeurotensin is a gut-brain peptide with both inhibitory and excitatory actions on the colonic musculature; our objective was to understand the implications of this for motor patterns occurring in the intact colon of the rat. MethodsThe effects of neurotensin with concentrations ranging from 0.1-100 nM were studied in the intact rat colon in vitro, by investigating spatio-temporal maps created from video recordings of colonic motility before and after neurotensin. ResultsLow concentration of neurotensin (0.1-1 nM) inhibited propagating long distance contractions and rhythmic propagating motor complexes; in its place a slow propagating rhythmic segmental motor pattern developed. The neurotensin receptor 1 antagonist SR-48692 prevented the development of the segmental motor pattern. Higher concentrations of neurotensin (10 nM and 100 nM) were capable of restoring long distance contraction activity and inhibiting the segmental activity. The slow propagating segmental contraction showed a rhythmic contraction --relaxation cycle at the slow wave frequency originating from the interstitial cells of Cajal associated with the myenteric plexus pacemaker. High concentrations given without prior additions of low concentrations did not evoke the segmental motor pattern. These actions occurred when neurotensin was given in the bath solution or intraluminally. The segmental motor pattern evoked by neurotensin was inhibited by the neural conduction blocker lidocaine. ConclusionsNeurotensin (0.1-1 nM) inhibits the dominant propulsive motor patterns of the colon and a distinct motor pattern of rhythmic slow propagating segmental contractions develops. This motor pattern has the hallmarks of haustral boundary contractions. (J Neurogastroenterol Motil 2016;22:517-528)

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Section: Discussionmentioning

confidence: 99%

Neurotensin Changes Propulsive Activity into a Segmental Motor Pattern in the Rat Colon

Chen

Yang

et al. 2016

J Neurogastroenterol Motil

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“…It has been reported that motilin stimulates gastrointestinal smooth muscle contraction through a direct or indirect pathway, i.e., myenteric neurons (28), autonomic nervous system (16), or smooth muscles (36), and various reports have pointed out the importance of vagal nerves (2,10,14,40). Several studies have suggested that the main pathway of motilininduced gastrointestinal contractions is different in each spe- cies.…”

Section: Discussionmentioning

confidence: 99%

Physiological characteristics of gastric contractions and circadian gastric motility in the free-moving conscious house musk shrew (Suncus murinus)

Sakahara

Xie

Koike

et al. 2010

American Journal of Physiology-Regulatory, Integrative and Comp

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Physiological characteristics of gastric contractions and circadian gastric motility in the free-moving conscious house musk shrew (Suncus murinus). Am J Physiol Regul Integr Comp Physiol 299: R1106 -R1113, 2010. First published August 4, 2010 doi:10.1152/ajpregu.00278.2010.-Although many studies have demonstrated the physiological action of motilin on the migrating motor complex, the precise mechanisms remain obscure. To obtain new insights into the mechanisms, we focused on the house musk shrew (Suncus murinus, suncus used as a laboratory name) as a small model animal for in vivo motilin study, and we studied the physiological characteristics of suncus gastrointestinal motility. Strain gauge transducers were implanted on the serosa of the gastric body and duodenum, and we recorded gastrointestinal contractions in the free-moving conscious suncus and also examined the effects of intravenous infusion of various agents on gastrointestinal motility. During the fasted state, the suncus stomach and duodenum showed clear migrating phase III contractions (intervals of 80 -150 min) as found in humans and dogs. Motilin (bolus injection, 100-300 ng/kg; continuous infusion, 10-100 ng · kg Ϫ1 · min Ϫ1 ) and erythromycin (80 g·kg Ϫ1 · min Ϫ1 ) induced gastric phase III contractions, and motilin injection also increased the gastric motility index in a dose-dependent manner (P Ͻ 0.05, vs. saline). Pretreatment with atropine completely abolished the motilin-induced gastric phase III contractions. On the other hand, in the free-feeding condition, the suncus showed a relatively long fasting period in the light phase followed by spontaneous gastric phase III contractions. The results suggest that the suncus has almost the same gastrointestinal motility and motilin response as those found in humans and dogs, and we propose the suncus as a new small model animal for studying gastrointestinal motility and motilin in vivo.suncus; migrating motor complex; motilin; ghrelin; gastric motility DURING A FASTED STATE, THE stomach and small intestine undergo a temporally coordinated cyclic motor pattern known as migrating motor complex (MMC) in dogs (38) and humans (44). It has been established that these coordinated contractions consist of three phases, phase I (period of motor quiescence), phase II (period of preceding irregular contractions), and phase III (period of clustered potent contractions), and the MMC is stimulated by endogenous motilin that is released in the fasted state.Motilin was originally purified from porcine intestinal mucosa in the 1970s, and its molecular structure was determined to be a 22-amino-acid polypeptide. It has been demonstrated that plasma motilin is released at ϳ100-min intervals at the interdigestive state (20,21). Physiological study of motilin in vivo has been mainly performed by using dogs and humans, and endogenous motilin and exogenous motilin have been shown to induce phase III contractions through the cholinergic pathway because atropine pretreatment completely abolished the motilin-induced contra...

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“…Since the threshold for contraction is around −50 mV (Szurszewski, 1987), the proximal stomach is in a constant state of partial tone or contraction, and hence relatively small changes in membrane potential can have dramatic effects on muscle tone. In fact, as seen by the effects of vagotomy on GI motor function, extrinsic innervation exerts a greater degree of influence over tonic gastric (particularly fundic) function than intestinal function (Hall et al 1982;Meyer, 1987). …”

Section: Morphological and Electrophysiological Correlationsmentioning

confidence: 99%

Electrophysiological and morphological heterogeneity of rat dorsal vagal neurones which project to specific areas of the gastrointestinal tract

Browning¹,

Renehan²,

Travagli³

1999

The Journal of Physiology

114

193

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Vagal control of migrating motor complex in the dog

Cited by 72 publications

References 0 publications

Neurotensin Changes Propulsive Activity into a Segmental Motor Pattern in the Rat Colon

Neurotensin Changes Propulsive Activity into a Segmental Motor Pattern in the Rat Colon

Physiological characteristics of gastric contractions and circadian gastric motility in the free-moving conscious house musk shrew (Suncus murinus)

Electrophysiological and morphological heterogeneity of rat dorsal vagal neurones which project to specific areas of the gastrointestinal tract

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