Vagal Afferents Mediate Antinociception of Estrogen in a Rat Model of Visceral Pain: The Involvement of Intestinal Mucosal Mast Cells and 5-Hydroxytryptamine 3 Signaling

Yan, Xiu-Juan; Feng, Chen-Chen; Liu, Qing; Zhang, Liyan; Dong, Xiao; Liu, Zongliang; Cao, Zhijun; Mo, Jinqiu; Liu, Ying; Fang, Jing‐Yuan; Chen, Shengliang

doi:10.1016/j.jpain.2013.10.012

Cited by 29 publications

(26 citation statements)

References 67 publications

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“…Also, the antinociceptive effect of estradiol on adjuvant-induced hyperalgesia was reported [38]. Very recently, a study of Yan and colleagues indicated that estrogen can trigger vagus-mediated antinociception in a rat model of visceral pain [39]. Taken together, a decrease in plasma estrogen level may parallel an increase in nociceptive sensitivity, while elevated estrogen level may antagonize ovarian hormones depletion-induced pain facilitation.…”

Section: Discussionmentioning

confidence: 91%

Ovariectomy Results in Variable Changes in Nociception, Mood and Depression in Adult Female Rats

Wang

et al. 2014

PLoS ONE

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Decline in the ovarian hormones with menopause may influence somatosensory, cognitive, and affective processing. The present study investigated whether hormonal depletion alters the nociceptive, depressive-like and learning behaviors in experimental rats after ovariectomy (OVX), a common method to deplete animals of their gonadal hormones. OVX rats developed thermal hyperalgesia in proximal and distal tail that was established 2 weeks after OVX and lasted the 7 weeks of the experiment. A robust mechanical allodynia was also occurred at 5 weeks after OVX. In the 5th week after OVX, dilute formalin (5%)-induced nociceptive responses (such as elevating and licking or biting) during the second phase were significantly increased as compared to intact and sham-OVX females. However, chronic constriction injury (CCI) of the sciatic nerve-induced mechanical allodynia did not differ as hormonal status (e.g. OVX and ovarian intact). Using formalin-induced conditioned place avoidance (F-CPA), which is believed to reflect the pain-related negative emotion, we further found that OVX significantly attenuated F-CPA scores but did not alter electric foot-shock-induced CPA (S-CPA). In the open field and forced swimming test, there was an increase in depressive-like behaviors in OVX rats. There was no detectable impairment of spatial performance by Morris water maze task in OVX rats up to 5 weeks after surgery. Estrogen replacement retrieved OVX-induced nociceptive hypersensitivity and depressive-like behaviors. This is the first study to investigate the impacts of ovarian removal on nociceptive perception, negative emotion, depressive-like behaviors and spatial learning in adult female rats in a uniform and standard way.

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Section: Discussionmentioning

confidence: 91%

Ovariectomy Results in Variable Changes in Nociception, Mood and Depression in Adult Female Rats

Wang

et al. 2014

PLoS ONE

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“…As one of the vagus nerve many known functions is modulation of visceral afferent sensitivity; loss of this process might theoretically contribute to visceral pain. This logic is in keeping with the association of BPS with upper gut symptoms like chronic nausea and functional dyspepsia.…”

Section: Discussionmentioning

confidence: 99%

Autonomic neurophysiologic implications of disorders comorbid with bladder pain syndrome vs myofascial pelvic pain

Chelimsky

Yang

Sanses

et al. 2019

Neurourology and Urodynamics

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Aims The neuropathophysiology of a debilitating chronic urologic pain condition, bladder pain syndrome (BPS), remains unknown. Our recent data suggests withdrawal of cardiovagal modulation in subjects with BPS, in contrast to sympathetic nervous system dysfunction in another chronic pelvic pain syndrome, myofascial pelvic pain (MPP). We evaluated whether comorbid disorders differentially associated with BPS vs MPP shed additional light on these autonomic differences. Methods We compared the presence and relative time of onset of 27 other medical conditions in women with BPS, MPP, both syndromes, and healthy subjects. Analysis included an adjustment for multiple comparisons. Results Among 107 female subjects (BPS alone = 32; BPS with MPP = 36; MPP alone = 9; healthy controls = 30), comorbidities differentially associated with BPS included irritable bowel syndrome (IBS), dyspepsia, and chronic nausea, whereas those associated with MPP included migraine headache and dyspepsia, consistent with the distinct autonomic neurophysiologic signatures of the two disorders. PTSD (earliest), anxiety, depression, migraine headache, fibromyalgia, chronic fatigue, and IBS usually preceded BPS or MPP. PTSD and the presence of both pelvic pain disorders in the same subject correlated with significantly increased comorbid burden. Conclusions Our study suggests a distinct pattern of comorbid conditions in women with BPS. These findings further support our hypothesis of primary vagal defect in BPS as compared with primary sympathetic defect in MPP, suggesting a new model for chronic these pelvic pain syndromes. Chronologically, PTSD, migraine, dysmenorrhea, and IBS occurred early, supporting a role for PTSD or its trigger in the pathophysiology of chronic pelvic pain.

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“…Bilateral subdiaphragmatic vagotomy was performed as previously described . Under anesthesia with sodium pentobarbital, a midline incision was made to open the abdomen in rats.…”

Section: Methodsmentioning

confidence: 99%

“…Perivagal capsaicin treatment was performed as previously described . Following anesthetization with sodium pentobarbital, an upper midline laparotomy was performed and the abdominal vagal nerve trunks were exposed and isolated.…”

Section: Methodsmentioning

confidence: 99%

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Vagal afferent‐dependent cholecystokinin modulation of visceral pain requires central amygdala NMDA‐NR2B receptors in rats

Wang

Yan

et al. 2015

Neurogastroenterology Motil

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Vagal Afferents Mediate Antinociception of Estrogen in a Rat Model of Visceral Pain: The Involvement of Intestinal Mucosal Mast Cells and 5-Hydroxytryptamine 3 Signaling

Cited by 29 publications

References 67 publications

Ovariectomy Results in Variable Changes in Nociception, Mood and Depression in Adult Female Rats

Ovariectomy Results in Variable Changes in Nociception, Mood and Depression in Adult Female Rats

Autonomic neurophysiologic implications of disorders comorbid with bladder pain syndrome vs myofascial pelvic pain

Vagal afferent‐dependent cholecystokinin modulation of visceral pain requires central amygdala NMDA‐NR2B receptors in rats

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