Vacuum‐assisted closure improves the incorporation of artificial dermis in soft tissue defects: Terudermis^® and Pelnac^®

Abstract

As a dermal scaffold, artificial dermal substitutes allow the body to accomplish its own tissue regeneration through infiltration of cells and neovascularisation. However, they show not only rather lower take rates compared to autologous skin grafts alone, but they also require more time for sufficient vascular ingrowth to overlay the skin graft. To accelerate this overlaying, we applied vacuum-assisted closure negative-pressure settings over the artificial dermis: Terudermis(®) and Pelnac(®) grafts. Fourteen patients with complex tissue defects were treated, including bone exposure in two cases, tendon exposure in seven cases and soft tissue defects in five cases. Nine cases had combined wound infections. The time interval between the first artificial dermis graft and the second split-thickness skin graft over it was 7·64 days on average. Dermal substitutes took place completely in all cases and there were no graft failures.

Exposed tibial bone after burns: Flap reconstruction versus dermal substitute

“…NPWT, if successful, results in granulation tissue formation, whereas the application of a dermal substitute over granulation tissue is able to guide the distribution of granulation tissue over the area where the dermal substitute was applied. NPWT has also been observed to promote the ingrowth of dermal substitutes [38][39][40].…”

The use of dermal regeneration template (Pelnac®) in acute full-thickness wound closure: A case series

“…The same can be said with our experience of NWPT on Pelnac® in this case series. V.A.C.® therapy (KCI Licensing, Inc. San Antonio, TX) has been shown to decrease the time taken for neovascularisation of neodermis when applied to avascular wound beds, which implies a decreased risk of infection and reduced length of stay in a hospital [21].…”

Regeneration of mature dermis by transplanted particulate acellular dermal matrix in a rat model of skin defect wound

“…So, PADM could be implanted combined with autologous STSG by one-stage surgery, avoid two-stage surgery. The sheet dermal equivalent usually takes 2–3 weeks for sufficient vascular ingrowth to overlay the skin graft which will be almost fully survival [47]. The prepared PADM was implanted in combination with autologous STSG by one-stage surgery in this study for preclinical testing of a therapeutic dermal regeneration.…”