Vacuum arc plasma deposition of thin titanium dioxide films on silicone elastomer as a functional coating for medical applications

Boudot, C.; Kühn, Marvin; Kühn-Kauffeldt, M.; Schein, J.

doi:10.1016/j.msec.2016.12.045

Cited by 24 publications

(11 citation statements)

References 33 publications

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“…TiO 2 is a common additive to improve OCT image quality and has been extensively used as an FDAapproved additive for use in both pharmaceuticals and cosmetics [36,37]. However, there has been recent concern that it could pose cytotoxic effects at some concentrations [54,55]. While an in depth characterization of TiO 2 toxicity is beyond the scope of the current work, if TiO 2 is deemed an issue then alternative contrast agents can be used such as gold nanoparticles [56] or even pigments found within the human body such as melanin [57].…”

Section: Discussionmentioning

confidence: 99%

In situ volumetric imaging and analysis of FRESH 3D bioprinted constructs using optical coherence tomography

et al. 2022

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As 3D bioprinting has grown as a fabrication technology, so too has the need for improved analytical methods to characterize engineered constructs. This is especially challenging for engineered tissues composed of hydrogels and cells, as these materials readily deform when trying to assess print fidelity and other properties non-destructively. Establishing that the 3D architecture of the bioprinted construct matches its intended anatomic design is critical given the importance of structure-function relationships in most tissue types. Here we report development of a multimaterial bioprinting platform with integrated optical coherence tomography (OCT) for in situ volumetric imaging, error detection, and 3D reconstruction. We also report improvements to the Freeform Reversible Embedding of Suspended Hydrogels (FRESH) bioprinting process through new collagen bioink compositions, gelatin microparticle support bath optical clearing, and optimized machine pathing. This enables quantitative 3D volumetric imaging with micron resolution over centimeter length scales, the ability to detect a range of print defect types within a 3D volume, and real-time imaging of the printing process at each print layer. These advances provide a comprehensive methodology for print quality assessment, paving the way toward the production and process control required for achieving regulatory approval and ultimately clinical translation of engineered tissues.

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Section: Discussionmentioning

confidence: 99%

In situ volumetric imaging and analysis of FRESH 3D bioprinted constructs using optical coherence tomography

et al. 2022

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“…真空弧放电是一种发生在真空环境下的阴阳极放电现象，可电离几乎所有金属元素，而且产生的离子密度高，被广泛应用在加速器、石油测井用中子管、真空断路器、表面沉积和溅射、大功率真空开关等领域 [1][2][3][4][5][6] 。真空弧放电过程中，除产生金属原子和离子外，还会伴随产生金属液滴 [7][8][9] 。液滴是阴极斑喷射到真空中的金属颗粒，与阴极材料、表面熔融状态和等离子体参数等有关，对它的研究可以获得阴极斑内部信息，这对真空弧放电研究具有非常重要的意义。但在工程上，金属液滴属于大颗粒，沉积在样品表面会破坏材料表面涂层的均匀性，落在器壁上形成金属微粒降低器件绝缘强度，所以工程上希望尽量减少或避免金属液滴的产生 [10,11] 。因此，对金属液滴行为的研究是真空弧放电机理及器件应用研究的重要科学问题，具有非常重要的意义。目前研究真空弧液滴最常用的方法是收集法。它是一种离线测量方法，通过在阴极附近放置一块表面洁净的收集板，等放电结束后用电子扫描显微镜观察收集板上的液滴数量和直径分布。通过这种方法，S. Anders 等人研究了钨、铂、铜等阴极金属材料和放电弧流对液滴直径分布的影响规律。对这些金属来说，液滴直径大多介于 0.1 um~50 um 之间，而且直径越大，数量越少；阴极材料熔点越低，液滴数量越多、直径越大；放电弧流仅影响液滴数量，不会改变粒径分布 [12] 。J.…”

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Mie scattering based on-line measurement of droplet from vacuum arc

Dong¹,

Tian²,

Li³

et al. 2023

Acta Phys. Sin.

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Metal droplet is produced accompanied with vacuum arc discharge, which is important to the research of cathode spot and the application of vacuum arc. The droplet comes from the cathode spot crater and can reflect the physical process of the cathode spot. However, it will destroy the uniformity of surface deposition in engineering and should be avoided as much as possible. The measurement of metal droplet usually adopts off-line collector, which could not obtain the signal of the whole space and singe arc. In order to on-line measure the droplet, a new method by the Mie scattering is introduced in this paper, and its feasibility is investigated. The characteristic of the scattering light of titanium droplet is computed by the simulation code. The results indicate that the scattering light of the small droplet is distributed at all angle. With the increase of the diameter, the scattered light is more and more concentrated in the forward direction, which provides the possibility for the inversion of the signals of the droplets with different diameters. Then the detector is designed with different annuluses. When the detector is divided into 35 annuluses, the light energy coefficient matrix is easy to solve and the measurement system has a good resolution. The experimental setup was built and the preliminary experiment was carried out. The results indicate that the diameters of titanium droplets is mainly around 9.8 μm, which verifies the effectiveness of the Mie scattering method for measuring vacuum arc droplets. However, the small droplet information is not detected, so the droplet diameter distribution is quite different from the off-line measurement. The reason is that the signal-to-noise ratio of the measurement system is poor, which cannot effectively obtain the scattered signals of the small droplet. The experimental setup need be optimized further.

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“…() generated an argon‐copper plasma under low pressure and deposited the copper on inert surfaces using an electrical field ranging in strength from 30 to 150 W. They found that a field strength of 150 W deposited the most amount of copper evenly on the surfaces, and this correlated with an increased inhibitory effect of the surface against inoculated Pseudomonas species (De Vietro et al., ). Similar PECVD techniques have been used to create other antimicrobial and biocompatible surfaces such as silver‐encapsulated textiles (Brunon et al., ), copper alloy‐coated stainless steel (Wrona et al., ), and medical‐grade polydimethylsiloxanes covered in a titanium dioxide film (Boudot, Kühn, Kühn‐Kauffeldt, & Schein, ).…”

Section: Nanotechnology and Materials Science In Food Processingmentioning

confidence: 99%

Integration of Emerging Biomedical Technologies in Meat Processing to Improve Meat Safety and Quality

Ravensdale

Coorey

Dykes

2018

Comp Rev Food Sci Food Safe

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Modern-day processing of meat products involves a series of complex procedures designed to ensure the quality and safety of the meat for consumers. As the size of abattoirs increases, the logistical problems associated with large-capacity animal processing can affect the sanitation of the facility and the meat products, potentially increasing transmission of infectious diseases. Additionally, spoilage of food from improper processing and storage increases the global economic and ecological burden of meat production. Advances in biomedical and materials science have allowed for the development of innovative new antibacterial technologies that have broad applications in the medical industry. Additionally, new approaches in tissue engineering and nondestructive cooling of biological specimens could significantly improve organ transplantation and tissue grafting. These same strategies may be even more effective in the preservation and protection of meat as animal carcasses are easier to manipulate and do not have the same stringent requirements of care as living patients. This review presents potential applications of emerging biomedical technologies in the food industry to improve meat safety and quality. Future research directions investigating these new technologies and their usefulness in the meat processing chain along with regulatory, logistical, and consumer perception issues will also be discussed.

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Vacuum arc plasma deposition of thin titanium dioxide films on silicone elastomer as a functional coating for medical applications

Cited by 24 publications

References 33 publications

In situ volumetric imaging and analysis of FRESH 3D bioprinted constructs using optical coherence tomography

In situ volumetric imaging and analysis of FRESH 3D bioprinted constructs using optical coherence tomography

Mie scattering based on-line measurement of droplet from vacuum arc

Integration of Emerging Biomedical Technologies in Meat Processing to Improve Meat Safety and Quality

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