Vaccinium arctostaphylos, a common herbal medicine in Iran: Molecular and biochemical study of its antidiabetic effects on alloxan-diabetic Wistar rats

Feshani, Aboozar Monavar; Kouhsari, Shideh Monatasser; Mohammadi, Seyed Abolghasem

doi:10.1016/j.jep.2010.09.002

Cited by 67 publications

(28 citation statements)

References 48 publications

(46 reference statements)

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“…The results of the present study are in accord with the studies on the effects of whortleberry in alloxan-diabetic Wistar rats [17] and type 2 diabetic patients [12]. As far as we know after searching various databases, the bioactives mediating the anti-hyperglycemic effect of whortleberry have not yet been characterized.…”

Section: Discussionsupporting

confidence: 89%

“…Very little research has been conducted on the anti-hyperglycemic effect of whortleberry. An ethanolic extract of whortleberry fruit was shown to have an anti-hyperglycemic effect in alloxan-diabetic Wistar rats [17]. Further, administration of the whortleberry leaf extract (250 mg every 8 h) to mildly hyperglycemic type 2 diabetic patients without any other anti-hyperglycemic agent lowered blood levels of fasting glucose significantly compared with baseline in a 4-week randomized, double-blind, placebo-controlled clinical trial [12].…”

Section: Introductionmentioning

confidence: 99%

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Anti-Hyperglycemic Effect of Vaccinium arctostaphylos in Type 2 Diabetic Patients: A Randomized Controlled Trial

Kianbakht

Abasi²,

Dabaghian

2013

Complement Med Res

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Background: Type 2 diabetes mellitus is a common disease. Preliminary data indicate that Vaccinium arctostaphylos L. (Caucasian whortleberry) has a potential effect in glycemic control. Thus, the efficacy and safety of a standardized whortleberry fruit hydroalcoholic extract in the treatment of type 2 diabetic patients were studied. Methods: This randomized double-blind placebo-controlled clinical trial consisted of 37 patients aged 40-60 years with type 2 diabetes who were resistant to conventional oral anti-hyperglycemic drugs. The patients were treated with the whortleberry fruit hydroalcoholic extract (1 capsule = 350 mg, every 8 h for 2 months) in combination with anti-hyperglycemic drugs, and the effects on the blood levels of fasting glucose, 2-hour postprandial glucose, glycosylated hemoglobin (HbA1c), and liver/kidney function were tested, evaluated, and compared with a placebo group (n = 37). Results: The extract significantly lowered the blood levels of fasting glucose, 2-h postprandial glucose, and HbA1c (p = 0.007, p <0.001, and p = 0.005, respectively) without any significant effects on the liver/kidney function (p >0.05) compared with placebo at the end. No adverse effects were reported. Conclusion: Whortleberry may safely improve glycemic control in type 2 diabetic patients.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Anti-Hyperglycemic Effect of Vaccinium arctostaphylos in Type 2 Diabetic Patients: A Randomized Controlled Trial

Kianbakht

Abasi²,

Dabaghian

2013

Complement Med Res

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“…Other plants known for their antioxidant properties include Capparis deciduas, Camellia sinensis, Emblica officinalis, Ficus bengalensis, Musa sapientum and Punica granatum [151] . Additionally, the antidiabetic effects of fruit of Vaccinium arctostaphylos L. (Ericaceae), which is traditionally used in Iran for improving of health status of diabetic patients, was found to encounter several machinaries among which were the notable rising of the erythrocyte superoxide dismutase (57%), glutathione peroxidase (35%) and catalase (19%) activities of the alloxantreated rats [223] . Hyperglycemia-induced aldose reductase activation results in the depletion of NADPH which is required for GSH reductase, hence, altering endogenous defense system.…”

Section: Antioxidantsmentioning

confidence: 99%

Phytotherapy in diabetes: Review on potential mechanistic perspectives

El‐Abhar

Schaalan

2014

WJD

108

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Diabetes mellitus (DM) is a widely spread epidemic disease that results from the absence of insulin, decreased secretion and/or impaired function. Since DM is a multifactorial disease, the available pharmaceuticals, despite their sensible treatment, target mostly one pathway to control hyperglycemia and encounter several side effects. Therefore, new therapeutic paradigms aim to hit several pathways using only one agent. Traditionally, antidiabetic plants and/or their active constituents may fulfill this need. More than 200 species of plants possess antidiabetic properties which were evaluated mostly by screening tests without digging far for the exact mode of action. Searching among the different literature resources and various database and in view of the above aspects, the present article provides a comprehensive review on the available antidiabetic plants that have been approved by pharmacological and clinical evaluations, and which their mechanism(s) of action is assured. These plants are categorized according to their proved mode of action and are classified into those that act by inhibiting glucose absorption from intestine, increasing insulin secretion from the pancreas, inhibiting glucose production from hepatocytes, or enhancing glucose uptake by adipose and muscle tissues. The current review also highlights those that mimic in their action the new peptide analogs, such as exenatide, liraglutide and dipeptidylpeptidase-4 inhibitors that increase glucagon-like peptide-1 serum concentration and slow down the gastric emptying.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Hypoglycaemic nutraceuticals; Antidiabetic phyto-constituents; Medicinal plants; Phytotherapy; Diabetes mellitus Core tip: Diabetes is a serious metabolic disorder that is currently treated by different types of synthetic oral hypoglycemic agents, in addition to insulin. However, due to the unwanted side effects, the efficacies of these compounds are debatable and there is a demand for new compounds for the treatment of diabetes. Therefore, attention has been directed towards nutraceuticals originating from plants that are rich in antidiabetic phyto-constituents. Although the evidenced-based therapeutic usage of many plants is scarce, the plants cited in this review are those reputed traditionally for their antidiabetic effect and that were verified either experimentally or clinically.El-Abhar HS, Schaalan MF. Phytotherapy in diabetes: Review on potential mechanistic perspectives. World J Diabetes 2014; 5(2): 176-197 Available from:

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“…The possible mechanism producing this effect may be CSLM and CSRM-induced release of insulin from some surviving β-cells [13]. This assumption is supported by the fact that some herbal preparations can stimulate β-cells regeneration and peripheral glucose consumption in alloxanand streptozotocin-induced diabetic rats [4,14].…”

Section: Discussionmentioning

confidence: 91%