Vaccinia zoonótica en Colombia: evidencia acumulativa de la emergencia de los poxvirus en el mundo

Páez-Martínez, Andrés; Laiton‐Donato, Katherine; Usme-Ciro, José A.

doi:10.15446/rsap.v20n6.67962

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…La reciente ocurrencia de infecciones por el virus vaccinia en animales y humanos en distintos lugares de la geografía colombiana, sumadas a otras por este y por otros virus pertenecientes al género Orthopoxvirus (familia Poxviridae), constituyen una evidencia de la emergencia de este género, con características epidemiológicas de interés para la salud pública (16). De acuerdo con José Esparza, Schrick y colaboradores, no se ha identificado en el mundo ninguna vacuna basada en el cowpox.…”

Section: El Virus De La Vacuna Colombianaunclassified

El virus de la vacuna colombiana de viruela: ¿cowpox o horsepox?

Jiménez¹,

Tribín²

2022

Med.

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En 1842 se inició la producción de vacuna animal para el control de la viruela con los trabajos de Giuseppe Negri, quien inoculó el cowpox en terneras e inició en Nápoles (Italia) la vacunación mediante ese procedimiento. El método fue adoptado por varios países del mundo. En Colombia, durante 1897 comenzó la producción de la vacuna animal con la creación de un laboratorio central de producción de vacunas denominado Parque de Vacunación, dirigido por el joven médico veterinario Jorge Lleras Parra. De acuerdo con sus escritos, siempre empleó el mismo virus. Sostuvo que la vacuna colombiana estaba preparada con virus equino horsepox y no con cowpox como se creía. Los estudios genómicos realizados sobre la vacuna de Lleras Parra confirmaron que el virus empleado estaba relacionado con el horsepox.

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Section: El Virus De La Vacuna Colombianaunclassified

El virus de la vacuna colombiana de viruela: ¿cowpox o horsepox?

Jiménez¹,

Tribín²

2022

Med.

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Excess Child Mortality Associated With Colombia’s Armed Conflict, 1998-2019

Moe,

Villaveces,

Montoya

et al. 2024

JAMA Netw Open

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ImportanceArmed conflicts are directly and indirectly associated with morbidity and mortality due to destruction of health infrastructure and diversion of resources, forced displacement, environmental damage, and erosion of social and economic security. Colombia’s conflict began in the 1940s and has been uniquely long-lasting and geographically dynamic.ObjectiveTo estimate the proportion of infant and child mortality associated with armed conflict exposure from 1998 to 2019 in Colombia.Design, Setting, and ParticipantsThis ecological cohort study includes data from all 1122 municipalities in Colombia from 1998 to 2019. Statistical analysis was conducted from February 2022 to June 2023.ExposureArmed conflict exposure was measured dichotomously by the occurrence of conflict-related events in each municipality-year, enumerated and reported by the Colombian National Center for Historic Memory.Main Outcomes and MeasuresDeaths among children younger than 5 years and deaths among infants younger than 1 year, offset by the number of births in that municipality-year, enumerated by Colombia’s national vital statistics.ResultsThe analytical sample included 24 157 municipality-years and 223 101 conflict events covering the period from 1998 to 2019. Overall, the presence of armed conflict in a municipality was associated with a 52% increased risk of death for children younger than 5 years of age (relative risk, 1.52 [95% CI, 1.34-1.72]), with similar results for 1- and 5-year lagged analyses. Armed conflict was associated with a 61% increased risk in infant (aged &lt;1 year) death (relative risk, 1.61 [95% CI, 1.43-1.82]). On the absolute scale, this translates to a risk difference of 3.7 excess child deaths per 1000 births (95% CI, 2.7-4.7 per 1000 births) and 3.0 excess infant deaths per 1000 births (95% CI, 2.3-3.6 per 1000 births) per year, beyond what would be expected in the absence of armed conflict. Across the 22-year study period, the population attributable risk was 31.7% (95% CI, 23.5%-39.1%) for child deaths and 35.3% (95% CI, 27.8%-42.0%) for infant deaths.Conclusions and RelevanceThis ecological cohort study of Colombia’s spatiotemporally dynamic armed conflict suggests that municipal exposure to armed conflict was associated with excess child and infant deaths. With a record number of children living near active conflict zones in 2020, policy makers and health professionals should understand the magnitude of and manner in which armed conflicts directly and indirectly undermine child health.

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Vaccinia zoonótica en Colombia: evidencia acumulativa de la emergencia de los poxvirus en el mundo

Cited by 2 publications

References 29 publications

El virus de la vacuna colombiana de viruela: ¿cowpox o horsepox?

El virus de la vacuna colombiana de viruela: ¿cowpox o horsepox?

Excess Child Mortality Associated With Colombia’s Armed Conflict, 1998-2019

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