Vaccinia Virus Infection of the Rabbit Cornea

A Quantitative Rabbit Model of Vaccinia Keratitis

“…In the few studies in which corneal opacification or vascularization was recorded, the data were reported qualitatively as either presence or absence, with the duration of the signs, but disease severity was unreported. 14,19 A few of these studies also determined viral titers in infected eyes. 19,21,23 Proper evaluation of therapeutics and mechanisms of pathogenesis require quantitative analyses.…”

A review of compounds exhibiting anti-orthopoxvirus activity in animal models

“…In this model, the cornea is scarified with a needle and virus is applied to the eye. Lesions spread slowly and are limited to the vicinity of the inoculated area ( Darrell and Vrabec, 1971 ). Compounds found to be effective by topical application in this model include polyinosinic-polycytidylic acid (poly I:C, an interferon inducer), ribavirin, ara-A, 9-β- d -arabinofuranosylhypoxanthine 5′-monophosphate (ara-HxMP), trifluorothymidine (TFT), and 5-iodo-2′-deoxyuridine (5-iodo-dUrd).…”