volume 66, issue 7, P4413-4426 1992
DOI: 10.1128/jvi.66.7.4413-4426.1992
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Abstract: The vaccinia virus Bi gene encodes a 34-kDa protein with homology to protein kinases. In L cells infected nonpermissively with mutants containing lesions in the Bi gene (ts2 and ts25), the infectious cycle arrests prior to DNA replication. In this report, we demonstrate that DNA synthesis ceases when cultures infected with these mutants at 32°C are shifted to the nonpermissive temperature (39.5°C) in the midst of DNA replication. We also show that Bi protein is synthesized transiently during the early phase of…

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