Vaccines in the United States: a systematic review on history of evolution, regulations, licensing, and future challenges

Sathyanarayana, Sandeep Divate; Fernandes, Swapnil Dylan; Castelino, Lovely Joylen; Vadakkepushpakath, Anoop Narayanan; Shriram, Ravi Gundadka

doi:10.7774/cevr.2020.9.2.69

Cited by 7 publications

(4 citation statements)

References 8 publications

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“…Vaccination has long been regarded as the most effective means for combating infectious disease ( Rappuoli et al, 2014 ; Sathyanarayana et al, 2020 ). The Philippines began its national vaccine drive against COVID-19 on March 1, 2021, with the goal of vaccinating seventy million of its citizens by the end of the calendar year ( Inter-Agency Task Force for the Management of Emerging Infectious Disease, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Interrogating COVID-19 vaccine intent in the Philippines with a nationwide open-access online survey

Caple

Dimaano

Sagolili

et al. 2022

PeerJ

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To mitigate the unprecedented health, social, and economic damage of COVID-19, the Philippines is undertaking a nationwide vaccination program to mitigate the effects of the global pandemic. In this study, we interrogated COVID-19 vaccine intent in the country by deploying a nationwide open-access online survey, two months before the rollout of the national vaccination program. The Health Belief Model (HBM) posits that people are likely to adopt disease prevention behaviors and to accept medical interventions like vaccines if there is sufficient motivation and cues to action. A majority of our 7,193 respondents (62.5%) indicated that they were willing to be vaccinated against COVID-19. Moreover, multivariable analysis revealed that HBM constructs were associated with vaccination intention in the Philippines. Perceptions of high susceptibility, high severity, and significant benefits were all good predictors for vaccination intent. We also found that external cues to action were important. Large majorities of our respondents would only receive the COVID-19 vaccines after many others had received it (72.8%) or after politicians had received it (68.2%). Finally, our study revealed that most (21%) were willing to pay an amount of PHP 1,000 (USD20) for the COVID-19 vaccines with an average willing-to-pay amount of PHP1,892 (USD38).

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Section: Introductionmentioning

confidence: 99%

Interrogating COVID-19 vaccine intent in the Philippines with a nationwide open-access online survey

Caple

Dimaano

Sagolili

et al. 2022

PeerJ

View full text Add to dashboard Cite

show abstract

“…Vaccination has long been regarded as the most effective means for combating infectious 60 disease (Rappuoli et al, 2014;Sathyanarayana et al, 2020). The Philippines began its national vaccine drive against COVID-19 on March 1, 2021, with the goal of vaccinating seventy million of its citizens by the end of the calendar year (Inter-Agency Task Force for the Management of Emerging Infectious Disease, 2021).…”

Section: Introductionmentioning

confidence: 99%

Interrogating Changes in COVID-19 Vaccine Intent During the National Vaccine Rollout in the Philippines

Caple,

Dimaano,

Sagolili

et al. 2024

Preprint

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To mitigate the unprecedented health, social, and economic damage of COVID-19, the Philippines implemented a nation-wide vaccine program to mitigate the effects of the global pandemic. In a previous study, we interrogated COVID-19 vaccine intent in the country by deploying a nationwide open-access online survey, two months before the initial rollout of the national vaccination program that began in March of 2021. In this follow-up study, we explored the influence of the ongoing vaccine rollout on vaccine intent by deploying a similar survey six months after the initial rollout of vaccines had begun throughout the archipelago. Our data suggests that the presence of vaccines and vaccinated individuals in a Filipino community predicts vaccination intent. When directly asked if they were more willing to receive a vaccination than six months prior, 92.26% agreed to some extent that they were indeed more willing. Finally, despite the changes in the numbers of respondents who were more open to the COVID-19 vaccines, there were no significant changes in the predictive power of our Health Belief Model (HBM) constructs. For the most part, the HBM factors that predicted vaccination intent in our earlier study also predicted vaccination intent in this current study.

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“…Drugs are described as substances that are employed in the treatment, mitigation, medicine, or prevention of disease. Typically, disease-causing microorganisms, their toxins, or a denatured or dead version of one of their surface proteins are used to create vaccines [1][2][3][4]. Vaccines belong to a brand-new category of pharmaceutical medicines that can be classified as both medications and biological products.…”

Section: Introductionmentioning

confidence: 99%

Regulatory Framework: Vaccine Development in Us, India and Eu

et al. 2023

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Vaccine development usually takes around 7 y to come to the market after getting necessary regulatory approvals. But recent pandemics like Covid, Ebola, Swine Flu, have resulted in the collaboration of efforts between the government doing investments in vaccine development, academia, regulatory bodies, and industry. This has shortened the timelines for approval for vaccines. In 2009, HINI, Swine flu vaccines took 93 d for identifying the vaccine candidate for clinical trials. In 2014, for Ebola vaccine, it was deployed while the epidemic was still going on. Ebola vaccine was developed in 5 y. In case of Covid (SARS-CoV-2) clinical trials were approved when 2 mo of the pandemic onset. Within a time of 9 mo about 138 vaccine candidates are being reviewed for approval of EUA. This highly helps in the shortening of vaccine development and necessary approval. In this paper, we focused on the regulatory framework of vaccine development in INDIA, US and EU.

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Vaccines in the United States: a systematic review on history of evolution, regulations, licensing, and future challenges

Cited by 7 publications

References 8 publications

Interrogating COVID-19 vaccine intent in the Philippines with a nationwide open-access online survey

Interrogating COVID-19 vaccine intent in the Philippines with a nationwide open-access online survey

Interrogating Changes in COVID-19 Vaccine Intent During the National Vaccine Rollout in the Philippines

Regulatory Framework: Vaccine Development in Us, India and Eu

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