Vaccines for fertility regulation of wild and domestic species

Bradley, Mark P.; Eade, Joyce; Penhale, J.; Bird, Peter H.

doi:10.1016/s0168-1656(99)00112-1

Cited by 34 publications

(22 citation statements)

References 31 publications

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“…They may or may not need to be reversible depending on the application (Hoskinson et al 1990, Aitken 2002. However, an additional but critical requirement for infertility vaccines intended for broad-scale uses, such as wildlife population control, is that they must be species-specific (Bradley et al 1999). Lack of species-specificity of antifertility vaccines is widely documented for a range of reproductive antigens from sperm (Bandivdekar et al 1991, Naz 2000, egg (Barber & Fayrer-Hosken 2000) and hormones such as LHRH and human chorionic gonadotrophin (hCG) (Talwar 1997).…”

Section: Introductionmentioning

confidence: 99%

“…The need for mouse-specific contraceptive antigens (Bradley et al 1999), coupled with the availability of a wide range of reproductive proteins in the mouse genome database, makes this an ideal species in which to identify species-specific contraceptive peptides. Once promising peptides have been identified, they could potentially be used in combination with immune enhancers (Ramsay & Ramshaw 1997) in the form of multivalent or polyepitope vaccines to generate stronger immune responses and more effective infertility.…”

Section: Introductionmentioning

confidence: 99%

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Development of mouse-specific contraceptive vaccines: infertility in mice immunized with peptide and polyepitope antigens

Hardy¹,

Clydesdale²,

Mobbs³

2004

Reproduction

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Mouse-specific immunocontraceptive peptides have been identified in mouse proteins with key roles in reproduction from sequence comparisons to other species and tested for efficacy as immunocontraceptive antigens. Peptides were derived from granulocyte-macrophage colony-stimulating factor (GMCSF), the placental 27 kDa heat-shock protein (HSP), leukemia inhibitory factor receptor (LIFR), oviduct glycoprotein (OGP), proliferin (PLF), prolactin (PRL), sperm protein SP56 and mouse zona pellucida subunits 1 and 3 (ZP1, ZP3). Fertility of female BALB/c mice was reduced after immunization with several peptides either conjugated to a carrier protein or in the form of recombinant polyepitopes. The most effective conjugated peptides (SP56, GMCSF and PRL) induced peptide-specific serum antibodies and reduced fertility by 50%. Fertility of mice was also reduced after immunization with polyepitope antigens containing up to five different peptides fused to maltose-binding protein, but antibodies were not produced against all the encoded peptides. The most effective polyepitope antigen (containing PLF, SP56, ZP1 and ZP3 peptides) reduced fertility by 50% but induced only SP56 and ZP1 antibodies. We demonstrate that lack of antibody response to a given peptide epitope (ZP3) can be overcome if repeated copies are used in the polyepitope antigen construct, but the effect varies between mouse strains. We conclude that infertility induced in mice with a range of peptide-based vaccines is dependent on antigen formulation and genetic factors but does not necessarily correlate with peptide-specific antibody levels. In light of these results, strategies to improve the efficacy of peptide-based antifertility vaccines are discussed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of mouse-specific contraceptive vaccines: infertility in mice immunized with peptide and polyepitope antigens

Hardy¹,

Clydesdale²,

Mobbs³

2004

Reproduction

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“…Desde hace décadas se han llevado a cabo estudios con el fin de regular la actividad reproductiva en animales domésticos y salvajes (Bradley et al, 1999). Entre otros, la inmunización activa anti-GnRH se ha considerado una posible alternativa a la esterilización mediante procedimientos quirúrgicos convencionales.…”

Section: Discussionunclassified

Inmunizacion activa anti-GnRH en ovino (Ovis aries): morfometría testicular, histopatología y respuesta endocrina en corderos prepúberes

Gutierrez-Reinoso¹,

Aponte²,

Teran-Sinchiguano³

et al. 2017

SPERMOVA

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“…The feasibility of using active immunisation to regulate fertility has now been established both in animal studies [13][14][15][16] and in clinical trials [17]. In addition to providing further contraceptive choice for the human species, many of the strategies that have been explored are also applicable for limiting fertility in other species, including livestock, feral and companion animals [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…In addition to providing further contraceptive choice for the human species, many of the strategies that have been explored are also applicable for limiting fertility in other species, including livestock, feral and companion animals [13][14][15][16]. With respect to the development of vaccines for use in humans, a number of groups worldwide are carrying out research in this field, with the major activity to date based largely in India and in the USA.…”

Section: Introductionmentioning

confidence: 99%

The development of contraceptive vaccines

Delves

2002

Expert Opinion on Investigational Drugs

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The use of vaccination as a means of controlling fertility was established during the last decade with the publication of a successful Phase II trial demonstrating the efficacy of this approach to family planning. However, only this one Phase II trial has been completed despite a plethora of hormonal and gamete antigens that have been proposed as candidate vaccines. Improvements in the design and formulation of contraceptive vaccines are underway and will be a necessary prelude to further clinical trials. AbstractThe use of vaccination as a means of controlling fertility was established during the last decade with the publication of a successful phase II trial demonstrating the efficacy of this approach to family planning. However, only this one phase II trial has been completed despite a plethora of hormonal and gamete antigens that have been proposed as candidate vaccines. Improvements in the design and formulation of contraceptive vaccines are underway and will be a necessary prelude to further clinical trials.

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Vaccines for fertility regulation of wild and domestic species

Cited by 34 publications

References 31 publications

Development of mouse-specific contraceptive vaccines: infertility in mice immunized with peptide and polyepitope antigens

Development of mouse-specific contraceptive vaccines: infertility in mice immunized with peptide and polyepitope antigens

Inmunizacion activa anti-GnRH en ovino (Ovis aries): morfometría testicular, histopatología y respuesta endocrina en corderos prepúberes

The development of contraceptive vaccines

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