Vaccines development in India: advances, regulation, and challenges

Salalli, Rakshita; Dange, Jyoti Ram; Dhiman, Sonia; Sharma, Teenu

doi:10.7774/cevr.2023.12.3.193

Cited by 5 publications

(4 citation statements)

References 50 publications

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“…The development of a plague vaccine in 1897 played a key role in mitigating the impact, particularly in India and subsequent outbreaks in the 1900s [ 132 ]. The prevalence of plague cases markedly diminished throughout the twentieth century, attributable to advancements in medicine, sanitation, and the eradication of natural reservoirs [ 14 ].…”

Section: Vaccinementioning

confidence: 99%

The Natural and Clinical History of Plague: From the Ancient Pandemics to Modern Insights

Bennasar-Figueras

2024

Microorganisms

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The human pathogen Yersinia pestis is responsible for bubonic, septicemic, and pneumonic plague. A deeply comprehensive overview of its historical context, bacteriological characteristics, genomic analysis based on ancient DNA (aDNA) and modern strains, and its impact on historical and actual human populations, is explored. The results from multiple studies have been synthesized to investigate the origins of plague, its transmission, and effects on different populations. Additionally, molecular interactions of Y. pestis, from its evolutionary origins to its adaptation to flea-born transmission, and its impact on human and wild populations are considered. The characteristic combinations of aDNA patterns, which plays a decisive role in the reconstruction and analysis of ancient genomes, are reviewed. Bioinformatics is fundamental in identifying specific Y. pestis lineages, and automated pipelines are among the valuable tools in implementing such studies. Plague, which remains among human history’s most lethal infectious diseases, but also other zoonotic diseases, requires the continuous investigation of plague topics. This can be achieved by improving molecular and genetic screening of animal populations, identifying ecological and social determinants of outbreaks, increasing interdisciplinary collaborations among scientists and public healthcare providers, and continued research into the characterization, diagnosis, and treatment of these diseases.

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Section: Vaccinementioning

confidence: 99%

The Natural and Clinical History of Plague: From the Ancient Pandemics to Modern Insights

Bennasar-Figueras

2024

Microorganisms

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“…The prevention of infectious diseases through immunization has been consolidated as a fundamental pillar of public health, having achieved the successful eradication of smallpox and a drastic decrease in the incidence of numerous vaccine-preventable diseases [ 9 , 10 ]. However, to achieve optimal levels of community protection and prevent disease re-emergence, it is essential to understand the factors that influence vaccine acceptance [ 11 , 12 ]. Intention to receive a vaccine is influenced by a complex interplay of sociodemographic, cultural, psychological, and risk perception variables [ 13 , 14 ], highlighting the need for detailed research on population intention toward Mpox vaccination.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of intentions to receive monkeypox vaccine. A systematic review and meta-analysis

León-Figueroa,

Barboza,

Valladares-Garrido

et al. 2024

BMC Public Health

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Background Immunization, as a preventive strategy against infectious diseases, has consolidated its position as a fundamental pillar in the field of public health. Therefore, the present study aimed to determine the prevalence of the intention to receive the monkeypox (Mpox) vaccine. Methods A systematic review and meta-analysis of the available evidence was performed using five databases (PubMed, Scopus, Web of Science, Embase, and ScienceDirect) with a search strategy until July 24, 2023. Data analysis was performed in R software version 4.2.3. The quality of the included cross-sectional studies was assessed using the “JBI-MAStARI”. In addition, a subgroup analysis by population and continent was developed. Results Twenty-nine cross-sectional articles with a total sample of 52 658 participants were included. The pooled prevalence of intention to vaccinate against Mpox was 61% (95% CI: 53–69%; 52,658 participants; 29 studies; I2 = 100%). In the subgroup analysis, the intention to be vaccinated against Mpox according to continents was 64% (95% CI: 53–74%; 13,883 participants; 17 studies; I2 = 99%) in Asian countries, 43% (95% CI: 39–47%; 1538 participants; 3 studies; I2 = 53%) in African countries, 62% (95% CI: 45–78%; 35,811 participants; 6 studies; I2 = 99%) in European countries, and 63% (95% CI: 32–89%; 1426 participants; 3 studies; I2 = 99%) in American countries. In the subgroup analysis on the intention to be vaccinated against Mpox, according to study subjects, it was 54% (95% CI: 45–62%; 10,296 participants; 11 studies; I2 = 99%) in the general population, 57% (95% CI: 33–79%; 3333 participants; 10 studies; I2 = 99%) in health care workers, and 76% (95% CI: 70–82%; 39,029 participants; 8 studies; I2 = 98%) in the lesbian, gay, bisexual, transgender, and intersex (LGBTI) community. In addition, as a secondary outcome, a prevalence of refusal of Mpox vaccination was found to be 22% (95% CI: 16–30%; 45,577 participants; 21 studies; I2 = 99%). Conclusion The study highlights the importance of recognizing regional and subgroup disparities in Mpox vaccine willingness and refusal. It emphasizes the importance of employing strategies to achieve widespread vaccination coverage and safeguard public health worldwide. Terms used Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument (JBI-MAStARI), Prospective International Registry of Systematic Reviews (PROSPERO), and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).

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“…Introducing AI-based solutions requires compliance with strict guidelines from various regulatory bodies like the Central Drugs Standard Control Organization (CDSCO) and the Indian Council of Medical Research (ICMR). These bodies have been cautious in approving AI-driven technologies due to concerns about data privacy, ethical implications, and patient safety ( Salalli et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Exploring the antecedents of AI adoption for effective HRM practices in the Indian pharmaceutical sector

Goswami,

Jain,

Alam

et al. 2023

Front. Pharmacol.

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Purpose: The aim of this research is to investigate the factors that facilitate the adoption of artificial intelligence (AI) in order to establish effective human resource management (HRM) practices within the Indian pharmaceutical sector.Design/methodology/approach: A model explaining the antecedents of AI adoption for building effective HRM practices in the Indian pharmaceutical sector is proposed in this study. The proposed model is based on task-technology fit theory. To test the model, a two-step procedure, known as partial least squares structural equational modeling (PLS-SEM), was used. To collect data, 160 HRM employees from pharmacy firms from pan India were approached. Only senior and specialized HRM positions were sought.Findings: An examination of the relevant literature reveals factors such as how prepared an organization is, how people perceive the benefits, and how technological readiness influences AI adoption. As a result, HR systems may become more efficient. The PLS-SEM data support all the mediation hypothesized by proving both full and partial mediation, demonstrating the accuracy of the proposed model.Originality: There has been little prior research on the topic; this study adds a great deal to our understanding of what motivates human resource departments to adopt AI in the pharmaceutical companies of India. Furthermore, AI-related recommendations are made available to HRM based on the results of a statistical analysis.

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Vaccines development in India: advances, regulation, and challenges

Cited by 5 publications

References 50 publications

The Natural and Clinical History of Plague: From the Ancient Pandemics to Modern Insights

The Natural and Clinical History of Plague: From the Ancient Pandemics to Modern Insights

Prevalence of intentions to receive monkeypox vaccine. A systematic review and meta-analysis

Exploring the antecedents of AI adoption for effective HRM practices in the Indian pharmaceutical sector

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