Vaccine Timeliness: A Cost Analysis of the Implications of Delayed Vaccination

Curran, Desmond; Terlinden, A.; Poirrier, Jean-Etienne; Masseria, Cristina; Krishnarajah, Girishanthy

doi:10.1016/j.jval.2013.08.143

Cited by 14 publications

(13 citation statements)

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“…Interestingly, most children had early vaccination for measles 1 and 2 in this study, at rates that were dramatically higher than the early vaccination rates of previous studies 8 37. One possible explanation is that the measles outbreaks started in December 2012 in Sindh province which killed 360 children in 2012-2013 39 40.…”

Section: Discussioncontrasting

confidence: 57%

“…Factors associated with lack of childhood vaccination have been studied extensively, and specific patterns have been identified 8–11. In contrast, less is known about factors associated with delayed vaccination and whether these factors follow the same patterns in different societies 12–15.…”

Section: Introductionmentioning

confidence: 99%

“…Information about factors that influence the timeliness of childhood vaccination might be valuable for healthcare providers, programme managers and policymakers in identifying sub-populations at risk, which should be targeted with interventions and public health policies 16. The timeliness of childhood vaccination has received close attention in the USA and in Europe,8 but in-depth investigations in low-income countries have been limited, particularly in Pakistan. The purpose of this study was to examine the timeliness of childhood vaccination coverage and its determinants in Sindh province, Pakistan.…”

Section: Introductionmentioning

confidence: 99%

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Determinants of timeliness in early childhood vaccination among mothers with vaccination cards in Sindh province, Pakistan: a secondary analysis of cross-sectional survey data

et al. 2019

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ObjectiveUntimely vaccination refers to receiving the given dose before (early) or after (delayed) the recommended time window. The purpose of this study was to assess the extent of timeliness of childhood vaccinations and examine the determinants of vaccination timeliness in Sindh province, Pakistan.DesignCross-sectional analysis of data from the 2013 and 2014 Maternal and Child Health Program Indicator Surveys.SettingCommunity-based maternal and child health surveys.ParticipantsAmong 10 200 respondents of Maternal and Child Health Program Indicator Surveys, 1143 women who had a live birth in the 2 years preceding the survey were included.OutcomesAt the participants’ home, an interviewer asked mothers to show their children’s vaccination cards, which contained information regarding vaccinations. Children’s vaccination status was categorised into timely or early/delayed compared with vaccination schedule. A logistic regression analysis using Firth’s penalised likelihood was performed to identify factors associated with timeliness of vaccinations.Results238 children (20.8% of children who received a full set of basic vaccinations) received all vaccinations on schedule among children who received a full set of basic vaccinations. The percentages of timely vaccinations ranged from 2.3% for second measles vaccination to 89.3% for bacillus Calmette-Guérin. Child’s age and place of delivery were associated with timely vaccinations. Older child age and institutional delivery were associated with decreased timely vaccination rate.ConclusionsHome-based vaccination record is a key tool to improve the timeliness of vaccinations. The redesigned vaccination cards, the new electronic registries for vaccination card information and the vaccination tracking system to remind the second/third vaccination visits may be helpful to improve timely vaccinations for children under 2 years old.

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Section: Discussioncontrasting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Determinants of timeliness in early childhood vaccination among mothers with vaccination cards in Sindh province, Pakistan: a secondary analysis of cross-sectional survey data

et al. 2019

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“…For example, timely administration of infant pertussis vaccine reduces subsequent pertussis cases, hospitalizations, deaths, and medical costs in infants <1 year of age in the US. 13 The consequences of vaccine hesitancy or refusal, and possible interventions identified to contrast vaccine hesitancy and refusal 14 are shown in Tables I and II (available at www.jpeds.com).…”

Section: Consequencesmentioning

confidence: 99%

Vaccine Hesitancy and Refusal

McIntosh

Janda

Ehrich

et al. 2016

The Journal of Pediatrics

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ver the past few years, an increasing number of European pediatricians, particularly primary care pediatricians, are facing the growing threat of vaccine hesitancy and refusal, a sort of a "cultural epidemic," which seems to progressively affect the families of children under their care. In several communities, a growing number of individuals are delaying or refusing available recommended and/or mandatory vaccinations for themselves and their children. Furthermore, vaccination is increasingly perceived as unsafe and unnecessary by a rising number of parents, although it has been widely proven and recognized to be one of the greatest, safest, and most successful public health measures ever adopted. Pediatricians have a potential major influence on parental vaccine decisions. However, their task is complicated by the complexity of the vaccine hesitancy phenomenon and its multifactorial nature. 1,2 Programs based on physiciantargeted communication interventions, designed to reduce vaccine hesitancy in mothers of infants seen by trained physicians and to increase physician confidence in communicating about vaccines, are reported to have failed to reduce maternal vaccine hesitancy or to improve physician self-efficacy. 3 Our aim is to describe vaccine hesitancy and refusal in an effort to further raise the awareness of pediatricians on this potential threat for their communities, and, in particular, for children under their care.

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“…Recent measles [1] and pertussis [2] outbreaks have occurred in the presence of relatively high overall levels of coverage and have instead been associated with children who were age eligible for a vaccination but who were delayed in receiving a dose. Curran et al estimate that over 10% of pertussis cases in the U.S., and $1.3 million in costs, are tied to delayed pertussis vaccination [3].…”

Section: Introductionmentioning

confidence: 99%

Vaccination timeliness among newborns and infants in Ethiopia

Boulton¹,

Carlson²,

Wagner³

et al. 2019

PLoS ONE

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Background We characterize the risk factors for delayed polio dose 1, diphtheria-tetanus-pertussis (DTP) dose 1, pentavalent dose 1, and measles dose 1 in Ethiopian infants. We also examine the interaction between institutional delivery and demographic factors on the birth doses of the BCG and polio vaccines to better understand factors influencing vaccination. Methods Using the 2011 Ethiopia Demographic and Health Survey, we calculated the distribution of the study population across different demographic and vaccination characteristics. We computed acceleration factors using a multivariable accelerated failure time model with a Weibull distribution to account for left and right censoring. For the birth doses, we further specified an interaction term between institutional delivery and every other a priori specified independent variable to test whether institutional delivery modifies sociodemographic disparities in vaccination timeliness. Results Low wealth status, home delivery, and ethnicity are risk factors for delayed vaccination of polio 1, DPT 1, pentavalent 1, and measles 1. Religion is a risk factor for measles 1 vaccination delay and rural residence are risk factors for delayed DPT1 and polio 1 doses. For birth doses of polio and BCG, institutional delivery attenuated many sociodemographic disparities in vaccination delay, except for urbanicity, which showed rural dwellers with more delay than urban dwellers with an institutional vs home birth. Conclusions Less delayed vaccination among children with institutional deliveries highlights the importance of perinatal care and the potential for promoting healthy behaviors to parents. Persistent disparities between urban and rural residents, even among those with institutional births, can be targeted for future interventions. Timely vaccination is key to prevention of unnecessary childhood mortality.

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Vaccine Timeliness: A Cost Analysis of the Implications of Delayed Vaccination

Cited by 14 publications

References 0 publications

Determinants of timeliness in early childhood vaccination among mothers with vaccination cards in Sindh province, Pakistan: a secondary analysis of cross-sectional survey data

Determinants of timeliness in early childhood vaccination among mothers with vaccination cards in Sindh province, Pakistan: a secondary analysis of cross-sectional survey data

Vaccine Hesitancy and Refusal

Vaccination timeliness among newborns and infants in Ethiopia

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