2021
DOI: 10.1002/rmv.2273
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Vaccine‐induced immune thrombotic thrombocytopenia after vaccination against Covid‐19: A clinical dilemma for clinicians and patients

Abstract: Summary The coronavirus disease 2019 (Covid‐19) pandemic has had devastating effects on public health worldwide, but the deployment of vaccines for Covid‐19 protection has helped control the spread of SARS Coronavirus 2 (SARS‐CoV‐2) infection where they are available. The common side effects reported following Covid‐19 vaccination were mostly self‐restricted local reactions that resolved quickly. Nevertheless, rare vaccine‐induced immune thrombotic thrombocytopenia (VITT) cases have been reported in… Show more

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Cited by 38 publications
(51 citation statements)
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“…Therefore, still further studies are needed to figure out other underlying mechanisms of the PVT following vaccination and solve this paradox. A recent cohort study stated the incidence of PVT following COVID-19 was 392.3 per million people, which was significantly higher than in PVT following vaccination (AstraZeneca and Jansen vaccines were excluded from this study) (49,50).…”
Section: Discussionmentioning
confidence: 91%
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“…Therefore, still further studies are needed to figure out other underlying mechanisms of the PVT following vaccination and solve this paradox. A recent cohort study stated the incidence of PVT following COVID-19 was 392.3 per million people, which was significantly higher than in PVT following vaccination (AstraZeneca and Jansen vaccines were excluded from this study) (49,50).…”
Section: Discussionmentioning
confidence: 91%
“…In aHIT, it is not necessary for heparin to be present and other reasons same as free DNA do job of heparin. The free DNA attaches to PF4, and then platelets to make thrombus ( 49 ). The positive anti-PF4 antibody in seven out of nine reviewed cases somehow confirmed these findings.…”
Section: Discussionmentioning
confidence: 99%
“…Live attenuated vaccines (LAV) are the most immunogenic vaccines without any adjuvant due to their effectiveness to provoke the immune system or immunity to mimic the natural infection (Minor 2015 ). Live attenuated viruses contain viable viruses with low virulence properties, live attenuated viruses are weak enough not to cause any diseases in a typical immune system.…”
Section: Traditional Vaccine Platform Uses In Covid-19 Vaccine Developmentmentioning
confidence: 99%
“…They reproduce slowly in the body, hence providing a long-term immunity against the pathogen as it remains a continuous antigen source. Live attenuated vaccines reduce the need for booster doses with single immunization (Minor 2015 ). Protection through live attenuated vaccine can be lifelong because LAV elicits both innate and adaptive immune systems; additionally, the production is economically feasible (Vignuzzi et al 2008 ).…”
Section: Traditional Vaccine Platform Uses In Covid-19 Vaccine Developmentmentioning
confidence: 99%
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