Vaccine Design against Chagas Disease Focused on the Use of Nucleic Acids

Maldonado, Edio; Morales-Pison, Sebastián; Urbina, Fabiola

doi:10.3390/vaccines10040587

Cited by 4 publications

(3 citation statements)

References 140 publications

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“…Fortunately, a number of other recombinant T. cruzi proteins as well as attenuated T. cruzi parasites are emerging as potentially safe strategies for the development of a CD vaccine (Sańchez-Valdeź et al, 2015;Rios et al, 2019;da Costa et al, 2021;Rodrigues da Cunha et al, 2021). Researchers are also testing mRNA vaccines after their successful use in COVID-19 (Diaz-Hernandez et al, 2022;Maldonado et al, 2022).…”

Section: American Trypanosomiasis: Chagas Diseasementioning

confidence: 99%

Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?

Scariot

Staneviciute

Zhu

et al. 2022

Front. Cell. Infect. Microbiol.

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Nanotechnology is revolutionizing many sectors of science, from food preservation to healthcare to energy applications. Since 1995, when the first nanomedicines started being commercialized, drug developers have relied on nanotechnology to improve the pharmacokinetic properties of bioactive molecules. The development of advanced nanomaterials has greatly enhanced drug discovery through improved pharmacotherapeutic effects and reduction of toxicity and side effects. Therefore, highly toxic treatments such as cancer chemotherapy, have benefited from nanotechnology. Considering the toxicity of the few therapeutic options to treat neglected tropical diseases, such as leishmaniasis and Chagas disease, nanotechnology has also been explored as a potential innovation to treat these diseases. However, despite the significant research progress over the years, the benefits of nanotechnology for both diseases are still limited to preliminary animal studies, raising the question about the clinical utility of nanomedicines in this field. From this perspective, this review aims to discuss recent nanotechnological developments, the advantages of nanoformulations over current leishmanicidal and trypanocidal drugs, limitations of nano-based drugs, and research gaps that still must be filled to make these novel drug delivery systems a reality for leishmaniasis and Chagas disease treatment.

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Section: American Trypanosomiasis: Chagas Diseasementioning

confidence: 99%

Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?

Scariot

Staneviciute

Zhu

et al. 2022

Front. Cell. Infect. Microbiol.

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show abstract

“…DNA vaccines may provide an alternative for both the prevention and treatment of a variety of diseases, including Chagas disease. Therefore, it is suggested that suitable DNA vectors encoding antigens could be encapsulated in cationic lipid nanoparticles and used as vaccine systems to deliver an efficient vaccine against T. cruzi [ 137 ].…”

Section: Theranostic Nucleotidementioning

confidence: 99%

Nucleotides Entrapped in Liposome Nanovesicles as Tools for Therapeutic and Diagnostic Use in Biomedical Applications

et al. 2023

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The use of nucleotides for biomedical applications is an old desire in the scientific community. As we will present here, there are references published over the past 40 years with this intended use. The main problem is that, as unstable molecules, nucleotides require some additional protection to extend their shelf life in the biological environment. Among the different nucleotide carriers, the nano-sized liposomes proved to be an effective strategic tool to overcome all these drawbacks related to the nucleotide high instability. Moreover, due to their low immunogenicity and easy preparation, the liposomes were selected as the main strategy for delivery of the mRNA developed for COVID-19 immunization. For sure this is the most important and relevant example of nucleotide application for human biomedical conditions. In addition, the use of mRNA vaccines for COVID-19 has increased interest in the application of this type of technology to other health conditions. For this review article, we will present some of these examples, especially focused on the use of liposomes to protect and deliver nucleotides for cancer therapy, immunostimulatory activities, enzymatic diagnostic applications, some examples for veterinarian use, and the treatment of neglected tropical disease.

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“…Regarding the coronavirus only, more than 100 vaccine candidates against COVID-19 are currently undergoing development, and about 40% of them reached clinical trials [ 20 , 21 ]. Design of vaccines based on the use of nucleic acids delivered by nanoparticles currently attracts the most attention of researchers [ 22 , 23 , 24 , 25 ]. It is understandable that the development of this type of vaccine requires the involvement of researchers of very different specialties, including virologists, immunologists, specialists in drug delivery, nanotechnology, molecular biologists, and so on.…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges

Pozharov

Minko

2023

Pharmaceutics

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Over the past decades, many drugs based on the use of nanotechnology and nucleic acids have been developed. However, until recently, most of them remained at the stage of pre-clinical development and testing and did not find their way to the clinic. In our opinion, the main reason for this situation lies in the enormous complexity of the development and industrial production of such formulations leading to their high cost. The development of nanotechnology-based drugs requires the participation of scientists from many and completely different specialties including Pharmaceutical Sciences, Medicine, Engineering, Drug Delivery, Chemistry, Molecular Biology, Physiology and so on. Nevertheless, emergence of coronavirus and new vaccines based on nanotechnology has shown the high efficiency of this approach. Effective development of vaccines based on the use of nucleic acids and nanomedicine requires an understanding of a wide range of principles including mechanisms of immune responses, nucleic acid functions, nanotechnology and vaccinations. In this regard, the purpose of the current review is to recall the basic principles of the work of the immune system, vaccination, nanotechnology and drug delivery in terms of the development and production of vaccines based on both nanotechnology and the use of nucleic acids.

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Vaccine Design against Chagas Disease Focused on the Use of Nucleic Acids

Cited by 4 publications

References 140 publications

Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?

Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?

Nucleotides Entrapped in Liposome Nanovesicles as Tools for Therapeutic and Diagnostic Use in Biomedical Applications

Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges

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