Vaccination to Combat as an Approach to Reduce the Antibacterial Resistance..!

Kumavath, Ranjith

doi:10.15406/ijvv.2017.04.00074

Cited by 2 publications

(3 citation statements)

References 36 publications

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“…The structures of indole analogs (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) were first preoptimized utilizing Hyperchem 6.03 and Molecular Mechanics Force Field (MM+), and the generated geometries were refined further using the semi-empirical Parametric Method-3 (PM3). For geometry optimization, we chose a normal gradient limit of 0.04 kJ/A.…”

Section: Resultsmentioning

confidence: 99%

“…This encouraged many researchers to develop antibacterial agents. In 1928, Sir Alexander Fleming discovered penicillin from Penicillium notatum, and this discovery unlocked the development of many agents that were able to either kill bacteria or inhibit bacterial growth [1]. The discovery of antibacterial agents helped to increase the human life span, but irrational use of these agents led to the rise of bacterial resistance.…”

Section: Introductionmentioning

confidence: 99%

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In Silico Studies of Indole Derivatives as Antibacterial Agents

et al. 2023

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Objectives: Molecular docking and QSAR studies of indole derivatives as antibacterial agents.Methods: In this study, we used a multiple linear regressions (MLR) approach to construct a 2D quantitative structure activity relationship of 14 reported indole derivatives. It was performed on the reported antibacterial activity data of 14 compounds based on theoretical chemical descriptors to construct statistical models that link structural properties of indole derivatives to antibacterial activity. We have also performed molecular docking studies of same compounds by using Maestro module of Schrodinger. A set the molecular descriptors like hydrophobic, geometric, electronic and topological characters were calculated to represent the structural features of compounds. The conventional antibiotics sultamicillin and ampicillin were not used in the model development since their structures are different from those of the created compounds. Biological activity data was first translated into pMIC values (i.e. -log MIC) and used as a dependent variable in QSAR investigation. Results: Compounds with high electronic energy and dipole moment were effective antibacterial agents against S. aureus, indole derivatives with lower κ 2 values were excellent antibacterial agents against MRSA standard strain, and compounds with lower R value and a high 2 χ v value were effective antibacterial agents against MRSA isolate. Conclusion: Compounds 12 and 2 showed better binding score against penicillin binding protein 2 and penicillin binding protein 2a respectively.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In Silico Studies of Indole Derivatives as Antibacterial Agents

et al. 2023

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“…Hence, alternative approach to antibiotic therapy is of urgent need to avoid undesirable effects to the microbiota. Alternative therapies such as probiotic intervention, vaccination, and bacteriotherapy [51][52][53][54] have been developed. However, such alternative strategies are still at infancy stage; hence, focus on such strategies have to be encouraged.…”

Section: Antibiotic Therapy Enriches Argsmentioning

confidence: 99%

Metagenomics of Antimicrobial Resistance in Gut Microbiome

Imchen¹,

Kumavath²

2018

Metagenomics for Gut Microbes

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A healthy human body functions in sync with a wide array of gut microbes collectively known as human gut microbiome. They complement in a number of functions which are essential in our daily life such as in food metabolism. Various illnesses including colon cancer, autism, obesity, and autoimmune diseases have been linked to an imbalanced gut microbiota. Antibiotics are indispensable drug; however, the administration of antibiotics in humans as well as in animal farms has shown to increase antimicrobial resistance genes (ARGs) in gut microbiome. This is of serious concern since the commensals in gut microbiome could capture ARGs through horizontal gene transfer which in turn could cause postsurgical infections. In addition, numerous studies have consistently shown that the gut microbiome is unique to each individual. Hence, in-depth knowledge on the gut microbiota community and the factor responsible for shaping and spreading of ARGs is essential. This would in turn enable the development of custom-tailored personalized food and drugs in the future.

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Vaccination to Combat as an Approach to Reduce the Antibacterial Resistance..!

Cited by 2 publications

References 36 publications

In Silico Studies of Indole Derivatives as Antibacterial Agents

In Silico Studies of Indole Derivatives as Antibacterial Agents

Metagenomics of Antimicrobial Resistance in Gut Microbiome

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