Vaccination rates and adherence in pneumococcal conjugate vaccination in mature born infants before and after vaccination schedule change – A claims database analysis

Laurenz, Maren; Eiff, Christof von; Borchert, Kathrin; Jacob, Christian; Seidel, Karolin; Schley, Katharina

doi:10.1016/j.vaccine.2021.04.029

Cited by 12 publications

(7 citation statements)

References 4 publications

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“…In contrast to the 3 + 1 vaccination scheme adopted in China, Germany changed its PCV immunization scheme from 3 + 1 to 2 + 1 in 2015 given the improvement in national vaccination coverage and the vaccine’s immune effect and cost. The reduction in primary doses has increased vaccination coverage to some extent [ 24 ]. Therefore, to improve the demand for vaccines, vaccination strategies in China must consider the needs of residents, vaccine safety, cost, vaccination schemes, and, importantly, the indicated age range for vaccination.…”

Section: Discussionmentioning

confidence: 99%

Understanding vaccine hesitancy with PCV13 in children: Results of a survey in Shanghai, China

Ni¹,

Xu²,

Wang³

2023

PLoS ONE

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A questionnaire survey for parents of children under 5 years of age was conducted to analyze vaccine hesitancy with the 13-valent pneumococcal conjugate vaccine (PCV13) in Shanghai, China. A total of 892 valid questionnaires were collected. Descriptive statistical methods, Chi-square test and effect size of Cohen were used. Among participants, 421 (48.8%) had children who had been vaccinated with PCV13 before the survey while 227 (26.73%) planned vaccination with PCV13 in the future. The main reasons for not receiving vaccination were the fear of adverse reactions (79, 26.7%), beyond vaccination age (69, 23.3%), and no need to vaccinate (44, 14.9%). Reducing vaccine hesitancy and increasing vaccination willingness can be achieved through health interventions, lower vaccine prices, and the adjustment of vaccination strategies.

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Section: Discussionmentioning

confidence: 99%

Understanding vaccine hesitancy with PCV13 in children: Results of a survey in Shanghai, China

Ni¹,

Xu²,

Wang³

2023

PLoS ONE

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“…31, 32 Of infants born in 2016, only 73 % received a full series of the recommended pneumococcal vaccination scheme, vaccinations were frequently delayed, and nearly a quarter of infants did not receive a booster dose. 33 This low vaccination coverage calls for urgent improvement to enhance protection against opportunistic pneumococcal infections during large-scale viral waves that are expected to persist in the post-SARS-CoV-2 era.…”

Section: Discussionmentioning

confidence: 99%

Outbreak of severe community-acquired bacterial infections fromStreptococcus pyogenes, Streptococcus pneumoniae, Neisseria meningitidis, andHaemophilus influenzaeamong children in North Rhine-Westphalia (Germany), October to December 2022

Goretzki,

van der Linden,

Itzek

et al. 2023

Preprint

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Background: In late 2022, a surge of severe bacterial infections caused by S. pyogenes was reported in several European countries, including Germany. This study assessed disease burden and severity of hospitalizations for community-acquired bacterial infections with S. pyogenes, S. pneumoniae, N. meningitidis, and H. influenzae among children in North Rhine-Westphalia (NRW), Germany, during the last quarter of 2022 compared to long-term incidences. Methods: Hospital cases due to bacterial infections between October and December 2022 were collected from 59/62 (95 %) children's hospitals in NRW and combined with surveillance data (2016 - 2023) from the national reference laboratories for streptococci, N. meningitidis, and H. influenzae. Total cases in NRW and incidence rates from January 2016 to March 2023 were estimated by capture-recapture analyses. Expected annual deaths from the studied pathogens were calculated from national death cause statistics. Results: Between October and December 2022, 153 cases with high overall disease severity were reported with pneumonia being most common (59 %, n = 91). Incidence rates of bacterial infections declined at the beginning of the COVID-19 pandemic. In late 2022 and early 2023 a massive surge to levels unprecedented since 2016 was observed, mainly driven by S. pyogenes and S. pneumoniae. Observed deaths during the study period exceeded the expected number for the entire year in NRW by far (7 vs. 0.9). Discussion: The unprecedented peak of bacterial infections in late 2022 and early 2023 was caused by various mechanisms intertwined that require close surveillance and improved precautionary measures for future outbreaks.

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“…According to the data of the United Nations International Children's Emergency Fund and WHO, the latest global coverage of pneumococcal vaccination in 149 countries was estimated to be 49% in 2020 [29]. Pneumococcal vaccination coverage is high in North America and European countries: In children, it is 91.9%–92.4% in the USA (2013–2017) [30], 95.6% in Greece (2013) [31] and 91.2% in Germany (2016) [32]. In adults, it is 69.0% (95% CI, 67.5%–70.4%) in the USA (2013–2017) [33] and 56.0% (95% CI, 53.2%–58.8%) in Australia [34].…”

Section: Discussionmentioning

confidence: 99%

Pneumococcal vaccination coverage and willingness in mainland China

Shao

Chen

Zheng

et al. 2022

Tropical Med Int Health

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Objectives To estimate the coverage and willingness of pneumococcal vaccination and further explore the influencing factors of vaccination willingness among people in mainland China. Methods Literature searches were conducted independently by two researchers in English‐ and Chinese‐language databases from database inception to 6 October 2021. A random‐effects meta‐analysis model was used to derive summary vaccination coverage and willingness. Predefined subgroup analysis and meta‐regression were performed to explore the sources of heterogeneity. Results A total of 97 studies were included in this meta‐analysis. The summary vaccination coverage in 76 included studies was 21.7% (95% confidence interval [CI]: 17.2%–26.5%). Subgroup analysis shows that the summary coverage was 29.0% (95% CI, 20.4%–39.1%) among the permanent residents and 20.7% (95% CI, 12.4%–35.9%) among the floating residents. The eastern and central regions presented higher coverage than the western region. Notable differences were observed between the various study populations. A total of 27 studies provided an estimation of vaccination willingness, with a summary willingness of 51.2% (95% CI, 40.4%–61.9%). In subgroup analysis, the summary willingness was 57.9% (95% CI, 48.3%–67.2%) in urban areas and 52.3% (95% CI, 40.8%–63.8%) in rural areas. Parents with children and people with a history of pneumonia were more willing to be vaccinated than the elderly. Recommendations by family members and physicians, previous pneumococcal and influenza vaccination, perceived vaccination effectiveness and severity of disease and a history of pneumonia contributed to vaccination willingness. Conclusions Compared to global estimates and other countries, pneumococcal vaccination coverage and willingness are at a lower level in mainland China. Recommendations for vaccination by family members and doctors, a history of vaccination and the perception of pneumonia and vaccination are associated with greater willingness to be vaccinated.

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Vaccination rates and adherence in pneumococcal conjugate vaccination in mature born infants before and after vaccination schedule change – A claims database analysis

Cited by 12 publications

References 4 publications

Understanding vaccine hesitancy with PCV13 in children: Results of a survey in Shanghai, China

Understanding vaccine hesitancy with PCV13 in children: Results of a survey in Shanghai, China

Outbreak of severe community-acquired bacterial infections fromStreptococcus pyogenes, Streptococcus pneumoniae, Neisseria meningitidis, andHaemophilus influenzaeamong children in North Rhine-Westphalia (Germany), October to December 2022

Pneumococcal vaccination coverage and willingness in mainland China

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