Vaccination of neonates: Problem and issues

Hodgins, Douglas C.; Shewen, Patricia E.

doi:10.1016/j.vaccine.2011.12.047

Cited by 63 publications

(50 citation statements)

References 185 publications

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“…23 Maternally derived antibodies can interfere with the immune response in young infants; such interference is common with live vaccines, such as the measles vaccine, but can also occur with some protein vaccines. 24,25 Similarly, pas- Solicited reports of adverse events during the 7-day postvaccination period were recorded and analyzed in the first 200 infants enrolled at each study site.…”

Section: Discussionmentioning

confidence: 99%

A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants

Agnandji¹,

Lell²,

Fernandes³

et al. 2012

N Engl J Med

625

352

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Section: Discussionmentioning

confidence: 99%

A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants

Agnandji¹,

Lell²,

Fernandes³

et al. 2012

N Engl J Med

625

352

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“…Their discussion is beyond the scope of this article (56,57). The most widely documented are epitope masking, phagocytosis and elimination of vaccine antigen-maternal antibody complexes, neutralization of vaccines by maternal antibodies, anti-idiotypic antibodies, and downregulation of antigen-specific B lymphocytes by Fc g receptor II.…”

Section: Suppressive Effects Of Maternal (Passive) Antibodies On Immumentioning

confidence: 99%

Strategies for Design and Application of Enteric Viral Vaccines

Chattha

Roth

Saif

2015

Annu. Rev. Anim. Biosci.

112

117

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Enteric viral infections in domestic animals cause significant economic losses. The recent emergence of virulent enteric coronaviruses [porcine epidemic diarrhea virus (PEDV)] in North America and Asia, for which no vaccines are available, remains a challenge for the global swine industry. Vaccination strategies against rotavirus and coronavirus (transmissible gastroenteritis virus) infections are reviewed. These vaccination principles are applicable against emerging enteric infections such as PEDV. Maternal vaccines to induce lactogenic immunity, and their transmission to suckling neonates via colostrum and milk, are critical for early passive protection. Subsequently, in weaned animals, oral vaccines incorporating novel mucosal adjuvants (e.g., vitamin A, probiotics) may provide active protection when maternal immunity wanes. Understanding intestinal and systemic immune responses to experimental rotavirus and transmissible gastroenteritis virus vaccines and infection in pigs provides a basis and model for the development of safe and effective vaccines for young animals and children against established and emerging enteric infections.

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“…Indeed, fetal and neonatal immunity clearly differs from adults, although inflammatory responses can be generated. Supplementary Table 6 summarizes the data on the postnatal development of immune functioning in human, rat and mouse [72][73][74][75][76][77][78]. To our knowledge no information is available on immune function development in the minipig.…”

Section: Immune Function Development (Supplementary Table 6)mentioning

confidence: 99%