Vaccination of Chickens with a Clone-Selected Lastoa Strain of Newcastle Disease Virus ,

Eidson, C. S.; Kleven, S. H.

doi:10.3382/ps.0590976

Cited by 12 publications

(9 citation statements)

References 8 publications

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“…Results of this work could be referred to the difference in the potency and in the immunogenicity or the antigenic relation between the vaccinal and the challenge strain. Similar explanation was stated (Schloer et al, 1975;Eidson and Kleven, 1980;Russel and Alexander, 1983).…”

Section: Discussionsupporting

confidence: 80%

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The effect of different Newcastle disease live vaccines and vaccination schedules on the immune response and performance of broiler chickens serologically positive to Mycoplasmas

Amer

El-Ghany

2006

Journal of Veterinary Medical Research

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This study was conducted to investigate the efficacy of the Newcastle disease (ND) live vaccines from different commercial sources used in different programs for vaccination of chicks having maternal antibodies against Mycoplasma infection. The immune response was estimated using HI and challenge tests. The effect on the chicken performance was estimated by the detection of the body weight gain. The role of vaccines in stimulating respiratory bacterial stress was pointed out by the lesion scores.Birds vaccinated with live vaccines from source (2) showed higher HI titers than those vaccinated with vaccine from source (1) and birds received the 2 nd vaccination from heterologous source showed lower titers than those received from homologous source. Results of the challenge test indicated that birds vaccinated with live ND vaccines from one source and those vaccinated with Hitchner B1 at 33-days of age instead of La Sota showed 100% protection rate as compared with 95 % followed by vaccination with heterologous La Sota. Birds received Hitchner B1 of vaccine source (1) showed only 85% protection rate. All vaccinated chicken groups showed feed conversion rates lower than the non-vaccinated control one. Groups received Hitchner B 1 as a 3 rd dose of the vaccine showed higher rates than those vaccinated with La Sota.Results of the lesion score for chronic respiratory disease (CRD) in vaccinated groups with different regimes revealed that birds received ND vaccinal strains from source (1) having higher scores than those received ND vaccines from the 2nd source. Administration of Hitchner B1 vaccine at 33-days of age showed lower scores. Hitchner B1 can be recommended in vaccination of chickens derived from Mycoplasma infected hens. ef Su -Beni Veterinary Medical Journal

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Section: Discussionsupporting

confidence: 80%

“…Furthermore, the field ND viruses are found to be different antiginically from the used vaccines (Panshsin et al, 2002). Eidson and Kleven, (1980) stated that ND vaccinal strains had the same pathogenic index differ in their immunogenicity based on geometric mean titers and challenge.…”

mentioning

confidence: 99%

The effect of different Newcastle disease live vaccines and vaccination schedules on the immune response and performance of broiler chickens serologically positive to Mycoplasmas

Amer

El-Ghany

2006

Journal of Veterinary Medical Research

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“…Field and diagnostic laboratory reports together with published information have suggested that such changes, within strains, have perhaps occurred (Eidson et al, 1977;Eidson and Kleven, 1980;Zygraich et al, 1978). It has been reported to the authors that some have been cloned and others passaged through chickens in attempts to increase their immunogenicity and also reduce pathogenicity.…”

Section: Introductionmentioning

confidence: 88%

Comparative Immune Response from Vaccinating Chickens with Lentogenic Newcastle Disease Virus Strains

Winterfield

Dhillon

1981

Poultry Science

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The immune response of chickens to 11 isolates of LaSota strain Newcastle disease virus (NDV) and to 7 isolates of B1 strain NDV was studied in specific-pathogen-free chickens. Most of the vaccine strains were from commercial vaccine producers. Comparison of immunogenicity were made of these vaccines; five other lentogenic NDV strains, not used commercially, were also evaluated. From the criteria of hemagglutination inhibition (HI) and virus serum (VN) neutralizing titers, differences were observed with certain isolates within the LaSota and B1 vaccine groups. Whereas the majority of vaccine strains fell within a predictable range, some proved considerably less in their ability to engender expected titers. Two-to threefold differences in titers were observed with some of the strains compared. Two cloned LaSota NDV strains did not compare favorably, or with expected higher titers, with uncloned or conventional LaSota strain virus isolates. Similarly, certain B1 and LaSota strains passaged in chickens did not demonstrate a greater immunogenic potential over conventional, commercial vaccines of similar strain designation but not passaged in chickens. Whereas none of the NDV strains demonstrated evidence of neurotropism or lethality, postvaccination respiratory reactions were difficult, if not impossible, to evaluate in laboratory isolation units. The complexity of selecting ND vaccines for field use is discussed briefly.

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“…The ND strains show heterogenicity in size of plaques which may lead to the level of post-vaccination reactions usually associated with the use of live ND vaccines. Cloned vaccines which contain only one set of genetic information have the advantage of being more stable than mixed virus strain vaccines (11)(12)(13). This study attempts to select a homogenous population from LaSota strain of NDV and to introduce it as a candidate for developing a live vaccine against ND.…”

Section: Introductionmentioning

confidence: 99%

“…Lentogenic strains such as the Hitchner B1 and LaSota are widely used as live vaccines against ND (9). The vaccines are mixtures of sub-populations which differ significantly from each other in immunogenicity and pathogenicity (10,11). These sub-populations may differ in plaque morphology which correlates with virus virulence.…”

Section: Introductionmentioning

confidence: 99%

Clone Purification, Characterization and Standardization of LaSota Strain for Developing a Live Vaccine against Newcastle Disease Virus

et al. 2014

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Background and Aims: Newcastle disease (ND) is one of the most serious illnesses of chickens. Live vaccines are widely used to prevent chicken from the disease all over the world. Materials and Methods: To access the effective and potentiate ND vaccine, a homogenous subpopulation from LaSota strain was selected following cultivation of the virus on primary chicken embryofibroblast (CEF) cells. Pathogenicity indices and molecular characterization of a several plaques at 3rd passage were analyzed and then the selected clone was candidate for vaccine development. ND vaccine was prepared according to the standard protocols. Results: The immunogenicity of the live vaccine was examined in specific pathogen free (SPF) and commercial chickens. The geometric mean hemagglutination-inhibition (HI) titers induced in chickens vaccinated with the cloned vaccine were not significantly differ than those induced in chickens vaccinated with the similar ND clone vaccine. Conclusion: Efficacy of the ND vaccine was estimated against the virus challenge. The results indicate that the cloned vaccine could confer a complete protection against NDV.

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Vaccination of Chickens with a Clone-Selected Lastoa Strain of Newcastle Disease Virus ,

Cited by 12 publications

References 8 publications

The effect of different Newcastle disease live vaccines and vaccination schedules on the immune response and performance of broiler chickens serologically positive to Mycoplasmas

The effect of different Newcastle disease live vaccines and vaccination schedules on the immune response and performance of broiler chickens serologically positive to Mycoplasmas

Comparative Immune Response from Vaccinating Chickens with Lentogenic Newcastle Disease Virus Strains

Clone Purification, Characterization and Standardization of LaSota Strain for Developing a Live Vaccine against Newcastle Disease Virus

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