Vaccination management in children and adults with mastocytosis

Zanoni, Giovanna; Zanotti, Roberta; Schena, Donatella; Sabbadini, Chiara; Opri, Roberta; Bonadonna, Patrizia

doi:10.1111/cea.12882

Cited by 38 publications

(54 citation statements)

References 9 publications

(26 reference statements)

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“…1,2 These patients experienced mild reactions that did not require hospitalization nor recur with subsequent vaccinations. 1,2 However, the dermatology literature has yet to comment on this phenomenon. Here, we aim to determine the prevalence of vaccination reactions in patients with pediatric cutaneous mastocytosis.…”

Section: Introductionmentioning

confidence: 99%

“…Some MPCM patients experience symptoms due to the release of mediators from mast cells including flushing, pruritus, gastrointestinal upset, and anaphylaxis. Recently, the allergy and immunology literature has published data showing there may be a relationship between routine vaccinations and induction of symptoms in patients with cutaneous mastocytosis 1‐3 . Two retrospective studies found a higher rate of adverse reactions to vaccinations in children with all types of mastocytosis, including MPCM, when compared to the general population 1,2 .…”

Section: Introductionmentioning

confidence: 99%

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Assessing vaccination reactions in pediatric patients with maculopapular cutaneous mastocytosis

Johansen

Lawley

2021

Pediatric Dermatology

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Immunization compliance in the United States is declining, in part due to misinformation and fear surrounding adverse vaccination reactions. Recently, there have been data published in the allergy and immunology literature to show that there may be a relationship between routine vaccinations and induction of symptoms in cutaneous mastocytosis patients; however, this has not yet been explored in the dermatology literature. We sought to uncover the prevalence of vaccine reactions due to mast cell activation within our cohort of maculopapular cutaneous mastocytosis (MPCM) patients in order to contribute to ensuring administration safety, managing familial expectations, and encouraging continued adherence. Our results indicate that while incidence of reaction rates may be higher than the national average, they are mild and families should be counseled to follow recommended immunization schedule guidelines.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessing vaccination reactions in pediatric patients with maculopapular cutaneous mastocytosis

Johansen

Lawley

2021

Pediatric Dermatology

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“…Patients who reported a reaction to constituents of the vaccine or idiopathic anaphylaxis may also be at risk of AEFI, and therefore require an allergologist's evaluation to decide for subsequent vaccination schedule and setting. In patients with mastocytosis it is suggested to perform vaccination with single products and to extend observation time to 30 minutes at least, but a controlled setting is not usually required (28,70). Specific IgE antibodies to vaccine antigens are useless in the case of suspect hypersensitivity to the vaccine as they are produced in the normal immune response to immunisation, as mentioned above (43).…”

Section: Discussionmentioning

confidence: 99%

Allergic reactions after vaccination: translating guidelines into clinical practice

Radice

Carli

Macchia

et al. 2018

Eur Ann Allergy Clin Immunol

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Vaccination represents one of the most powerful medical interventions on global health.Despite being safe, sustainable, and effective against infectious and in some cases also non-infectious diseases, it's nowadays facing general opinion's hesitancy because of a false perceived risk of adverse events. Adverse reactions to vaccines are relatively rare, instead, and those recognizing a hypersensitivity mechanism are even rarer. The purpose of this review is to offer a practical approach to adverse events after vaccination, focusing on immune-mediated reactions with particular regard to their recognition, diagnosis and management. According to clinical features, we propose an algorythm for allergologic work-up, which helps in confirming hypersensitivity to vaccine, nonetheless ensuring access to vaccination. Finally, a screening questionnaire is included, providing criteria for immunisation in specialized care settings.

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“…31 They saw very few reactions and only recommend extending the normal 15-minute observation period to 30 minutes along with training for parents in how to recognize and manage allergic reactions. 31 They saw very few reactions and only recommend extending the normal 15-minute observation period to 30 minutes along with training for parents in how to recognize and manage allergic reactions.…”

Section: Anaphylaxismentioning

confidence: 99%

“…Zanoni and colleagues have looked at rates of vaccine reactions in their mastocytosis clinic. 31 They saw very few reactions and only recommend extending the normal 15-minute observation period to 30 minutes along with training for parents in how to recognize and manage allergic reactions.…”

Section: Anaphylaxismentioning

confidence: 99%

Developments in the field of allergy in 2017 through the eyes of Clinical and Experimental Allergy

Roberts

Almqvist

Boyle

et al. 2018

Clin Experimental Allergy

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Vaccination management in children and adults with mastocytosis

Cited by 38 publications

References 9 publications

Assessing vaccination reactions in pediatric patients with maculopapular cutaneous mastocytosis

Assessing vaccination reactions in pediatric patients with maculopapular cutaneous mastocytosis

Allergic reactions after vaccination: translating guidelines into clinical practice

Developments in the field of allergy in 2017 through the eyes of Clinical and Experimental Allergy

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