Vaccination is an integral strategy to combat antimicrobial resistance

Mullins, L.P.; Mason, Emily F.; Winter, Kaitlin; Sadarangani, Manish

doi:10.1371/journal.ppat.1011379

Cited by 7 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These vaccines, by curbing the spread of infectious diseases, can substantially reduce the reliance on antimicrobial agents. This reduction is crucial in veterinary and human medicine, as it can help to slow down the development of antimicrobial resistance (AMR), a growing concern in global health, something that is yet to be investigated ( 22 , 23 ). The environmental benefits of these vaccines are in line with One Health principles.…”

Section: Environmental Impactmentioning

confidence: 99%

Potential of mRNA-based vaccines for the control of tick-borne pathogens in one health perspective

González-Cueto,

de la Fuente,

López-Camacho

2024

Front. Immunol.

View full text Add to dashboard Cite

The One Health approach, which integrates the health of humans, animals, plants, and ecosystems at various levels, is crucial for addressing interconnected health threats. This is complemented by the advent of mRNA vaccines, which have revolutionized disease prevention. They offer broad-spectrum effectiveness and can be rapidly customized to target specific pathogens. Their utility extends beyond human medicine, showing potential in veterinary practices to control diseases and reduce the risk of zoonotic transmissions. This review place mRNA vaccines and One Health in the context of tick-borne diseases. The potential of these vaccines to confer cross-species immunity is significant, potentially disrupting zoonotic disease transmission cycles and protecting the health of both humans and animals, while reducing tick populations, infestations and circulation of pathogens. The development and application of mRNA vaccines for tick and tick-borne pathogens represent a comprehensive strategy in global health, fostering a healthier ecosystem for all species in our interconnected world.

show abstract

Section: Environmental Impactmentioning

confidence: 99%

Potential of mRNA-based vaccines for the control of tick-borne pathogens in one health perspective

González-Cueto,

de la Fuente,

López-Camacho

2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Furthermore, there are many infections that can be prevented with vaccines such as pneumonia, meningitis, and some respiratory infections as well as various forms of septicemia [ 93 , 94 , 95 ]. By vaccinating the elderly and at-risk sections of the population against these diseases, the incidence of infections can be reduced, thus potentially decreasing the need for antibiotics and reducing the selection pressure for antibiotic-resistant bacteria [ 96 , 97 ]. The results of a recent meta-analysis show that the effect of influenza vaccination on the number of antibiotic prescriptions or days of antibiotic use (Ratio Means (RoM) 0.71, 95% CI 0.62–0.83) is stronger compared to the effect of pneumococcal vaccination (RoM 0.92, 95% CI 0.85–1.00).…”

Section: Vaccination and Antibiotics Resistancementioning

confidence: 99%

Efficacy and Safety of Vaccinations in Geriatric Patients: A Literature Review

Ciarambino,

Crispino,

Buono

et al. 2023

Vaccines

View full text Add to dashboard Cite

With the progressive lengthening of the average age of the population, especially in some countries such as Italy, vaccination of the elderly is a fixed point on which most of the public health efforts are concentrating as epidemic infectious diseases, especially those of the winter, have a major impact on the progression of severe disease, hospitalization, and death. The protection of the elderly against acute infectious diseases should not only limit mortality but also have a positive impact on the fragility of these people in terms of less disability and fewer care needs. However, vaccination of the elderly population differs in efficacy and safety compared to that of other population categories since aging and the consequent loss of efficiency of the immune system lead to a reduction in the immunogenicity of vaccines without achieving a lasting antibody coverage. There are various strategies to avoid the failure of immunization by vaccines such as resorting to supplementary doses with adjuvant vaccines, increasing the dosage of the antigen used, or choosing to inoculate the serum relying on various routes of administration of the vaccine. Vaccination in the elderly is also an important factor in light of growing antibiotic resistance because it can indirectly contribute to combating antibiotic resistance, reducing theoretically the use of those agents. Furthermore, vaccination in old age reduces mortality from infectious diseases preventable with vaccines and reduces the same rate of resistance to antibiotics. Given the importance and complexity of the topic, in this review, we will deal with the main aspects of vaccination in the elderly and how it can influence mortality and healthcare costs, especially in those countries where population aging is more evident. Therefore, we conducted a systematic literature search in PubMed to identify all types of studies published up to 31 May 2023 that examined the association between vaccination and the elderly. Data extraction and quality assessment were conducted by two reviewers (PC and TC) who independently extracted the following data and assessed the quality of each study.

show abstract

“…and Escherichia coli are the most commonly isolated microorganisms. In addition, an increasing number of SSIs are caused by antibiotic-resistant pathogens such as methicillin-resistant S. aureus (MRSA) or Candida albicans 6 .…”

Section: Surgical Site Infections (Ssis)mentioning

confidence: 99%

Healthcare-associated infections in an orthopaedic setting: a multidisciplinary approach

Miccolis,

Siena,

Serpentino

et al. 2023

Lo Scalpello

View full text Add to dashboard Cite

Healthcare-associated infections (HAIs) are a significant problem in healthcare facilities, resulting in longer hospital stays, additional costs and inconvenience for patients. Surgical site infections are one of the most common types of HAIs. In this context, orthopaedics appears to be the surgical area that is most involved in claims for HAIs. This narrative review explores the landscape of HAIs, their prevalence, associated adverse events, preventive measures and overall impact by providing an overview of infections in elective orthopaedic surgery. In summary, a significant proportion of surgical site infections can be prevented by a comprehensive, multidisciplinary approach.

show abstract

Vaccination is an integral strategy to combat antimicrobial resistance

Cited by 7 publications

References 21 publications

Potential of mRNA-based vaccines for the control of tick-borne pathogens in one health perspective

Potential of mRNA-based vaccines for the control of tick-borne pathogens in one health perspective

Efficacy and Safety of Vaccinations in Geriatric Patients: A Literature Review

Healthcare-associated infections in an orthopaedic setting: a multidisciplinary approach

Contact Info

Product

Resources

About