Vaccination influences the evolution of classical swine fever virus

Ji, Wei; Niu, Dong Xiao; Si, Hongli; Ding, Nai-Zheng; He, Cheng-Qiang

doi:10.1016/j.meegid.2014.04.008

Cited by 56 publications

(54 citation statements)

References 40 publications

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“…When comparing the estimated substitution rates obtained in this study to in silico analyses from CSFV sequences from China, the E2-based substitution rates obtained from Chinese CSFV strains are higher than those observed across the fullgenome sequence in the presented study (Ji et al, 2014;Zhang et al, 2013). Similar evolutionary investigations of partial sequences revealed, for example, a substitution rate of 3.0610 23 substitutions site 21 year 21 (Ji et al, 2014;Zhang et al, 2013) for CSFV type 2 strains, which is similar to the substitution rate estimated in the presented study for the E2 protein gene ( (Ji et al, 2014), which is identical to the substitution rate for the full-genome sequences obtained in this study when estimated with the TN parameter (Table 1). These results suggest that BEAST analyses applied to only a few CSFV variants across a relatively short time frame within a geographically restricted area estimate results comparable to those obtained from large datasets.…”

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confidence: 51%

Evolution and molecular epidemiology of classical swine fever virus during a multi-annual outbreak amongst European wild boar

Goller

Gabriel

Dimna³

et al. 2016

Journal of General Virology

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Classical swine fever is a viral disease of pigs that carries tremendous socio-economic impact. In outbreak situations, genetic typing is carried out for the purpose of molecular epidemiology in both domestic pigs and wild boar. These analyses are usually based on harmonized partial sequences. However, for high-resolution analyses towards the understanding of genetic variability and virus evolution, full-genome sequences are more appropriate. In this study, a unique set of representative virus strains was investigated that was collected during an outbreak in French free-ranging wild boar in the Vosges-du-Nord mountains between 2003 and 2007. Comparative sequence and evolutionary analyses of the nearly full-length sequences showed only slow evolution of classical swine fever virus strains over the years and no impact of vaccination on mutation rates. However, substitution rates varied amongst protein genes; furthermore, a spatial and temporal pattern could be observed whereby two separate clusters were formed that coincided with physical barriers.

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mentioning

confidence: 51%

Evolution and molecular epidemiology of classical swine fever virus during a multi-annual outbreak amongst European wild boar

Goller

Gabriel

Dimna³

et al. 2016

Journal of General Virology

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“…Consequently, the use of lapinized vaccines or live attenuated vaccines has been one of the most common policies to control CSF in endemic countries (Blome, Moss, Reimann, Konig, & Beer, ). However, recent reports have shown the emergence of new CSFV strains resulting from the action of the positive selection pressure, due mainly to bottleneck effects generated by conventional vaccines (thereafter considered as positively selected strains; Hu et al, ; Ji, Niu, Si, Ding, & He, ; Perez, Diaz de Arce, et al, ; Rios et al, ; Shen et al, ). All the studies characterizing the action of the positive selection pressure on field CSFV strains, have shown, as a consensus, a decrease in the genetic diversity of the circulating CSFV strains (Hu et al, ; Ji et al, ; Perez, Diaz de Arce, et al, ; Rios et al, ; Shen et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…However, there is little information about the effect caused by this selective force on the virulence degree, antigenicity and pathogenicity of CSFV strains. In this regard, Perez, Diaz de Arce, et al ()) observed in one of the positively selected strains studied, a decrease in virulence with the emergence of a low virulent strain from its highly virulent ancestor (Perez, Diaz de Arce, et al, ; Postel et al, ), whereas Ji et al () and Hu et al () limited their study to analyse the genetic diversity of the strains but speculated about the possibility that the positively selected strain could have alterations in virulence and pathogenesis. Hence, it is still unclear how the positive selection pressure could affect the virulence and pathogenicity of CSFV and the implications of its epidemiological surveillance are far to be completely understood.…”

Section: Introductionmentioning

confidence: 99%

Positive selection pressure on E2 protein of classical swine fever virus drives variations in virulence, pathogenesis and antigenicity: Implication for epidemiological surveillance in endemic areas

Coronado

Rios

Frı́as

et al. 2019

Transbound Emerg Dis

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Classical swine fever (CSF), caused by CSF virus (CSFV), is considered one of the most important infectious diseases with devasting consequences for the pig industry. Recent reports describe the emergence of new CSFV strains resulting from the action of positive selection pressure, due mainly to the bottleneck effect generated by ineffective vaccination. Even though a decrease in the genetic diversity of the positively selected CSFV strains has been observed by several research groups, there is little information about the effect of this selective force on the virulence degree, antigenicity and pathogenicity of this type of strains. Hence, the aim of the current study was to determine the effect of the positive selection pressure on these three parameters of CSFV strains, emerged as result of the bottleneck effects induced by improper vaccination in a CSF‐endemic area. Moreover, the effect of the positively selected strains on the epidemiological surveillance system was assessed. By the combination of in vitro, in vivo and immunoinformatic approaches, we revealed that the action of the positive selection pressure induces a decrease in virulence and alteration in pathogenicity and antigenicity. However, we also noted that the evolutionary process of CSFV, especially in segregated microenvironments, could contribute to the gain‐fitness event, restoring the highly virulent pattern of the circulating strains. Besides, we denoted that the presence of low virulent strains selected by bottleneck effect after inefficient vaccination can lead to a relevant challenge for the epidemiological surveillance of CSF, contributing to under‐reports of the disease, favouring the perpetuation of the virus in the field. In this study, B‐cell and CTL epitopes on the E2 3D‐structure model were also identified. Thus, the current study provides novel and significant insights into variation in virulence, pathogenesis and antigenicity experienced by CSFV strains after the positive selection pressure effect.

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“…4,5 In India, vaccination failures can be attributed mainly to lower vaccine quality, inappropriate vaccination process and dose, antigenically variant strains and evolution of virulent strains influenced by vaccine pressure and positive selection. [5][6][7][8] Among all listed issues of vaccine failures, antigenic variation in circulating strains is the most challenging. 6,9,10 Based on genetic variation and phylogenetic analysis among all isolates, NDV strains are categorized into XVI genotypes and two classes.…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of an apoptotic strain of Newcastle disease virus isolated from an outbreak in India

Kumar

2015

Cancer Gene Ther

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Newcastle disease (ND) is a highly contagious disease of poultry. The ND virus (NDV) encodes an error-prone RNA-dependent RNA polymerase which can cause high mutation rate leading to the emergence of its new antigenic variants. Antigenic difference of NDV strains may result in massive outbreak in vaccinated and unvaccinated poultry flocks around the globe. Apart from its pathogenic potential NDV has been explored as an oncolytic agent for a broad range of human cancers. In the present study, we isolated a novel NDV strain from an outbreak in chicken flock from the eastern part of India. Molecular characterization showed the NDV strain to be virulent in nature. The complete genome sequence analysis of the newly isolated strains belongs to genotype XIII. Moreover, the newly isolated strain of NDV showed positive results in various apoptotic assays in human breast cancer cells, MCF-7. The study will be useful to explore the possibility of using a newly isolated strain of NDV for virotherapy.

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Vaccination influences the evolution of classical swine fever virus

Cited by 56 publications

References 40 publications

Evolution and molecular epidemiology of classical swine fever virus during a multi-annual outbreak amongst European wild boar

Evolution and molecular epidemiology of classical swine fever virus during a multi-annual outbreak amongst European wild boar

Positive selection pressure on E2 protein of classical swine fever virus drives variations in virulence, pathogenesis and antigenicity: Implication for epidemiological surveillance in endemic areas

Molecular characterization of an apoptotic strain of Newcastle disease virus isolated from an outbreak in India

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