Vaccination generates functional progenitor tumor-specific CD8 T cells and long-term tumor control
Carlos R. Detrés Román,
Michael W. Rudloff,
Frank Revetta
et al.
Abstract:Background: Immune checkpoint blockade (ICB) therapies are an important treatment for patients with advanced cancers; however only a subset of patients with certain types of cancer achieves durable remissions. Cancer vaccines are an attractive strategy to boost patient immune responses, but less is known about whether and how immunization can induce long-term tumor immune reprogramming and arrest cancer progression. We developed a clinically-relevant genetic cancer mouse model in which hepatocytes sporadically… Show more
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