Vaccination coverage and risk factors for incomplete vaccination in children with recurrent wheeze

Özkaya, Enis; Cambaz, Nevin; Kolsuz, L.D.; Aycan, N.; Calis, S.; Samanci, Nedim

doi:10.1016/j.aller.2010.07.008

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…As children with recurrent wheezing frequently receive steroid treatment and therefore are at risk to acquire viral respiratory infections, it is highly recommended that they be vaccinated with influenza virus vaccine (12). In reality, however, these children frequently receive delayed vaccination or even miss vaccination, and some studies reported that these populations should be closely monitored for timely vaccination (13). The average age of children with recurrent wheezing was older than that of healthy children, and the average age of vaccine-naive children with recurrent wheezing was older than that of vaccinenaive healthy children (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Immunogenicity and Safety of an Inactivated Trivalent Split Influenza Virus Vaccine in Young Children with Recurrent Wheezing

Bae

Choi

Kwon

et al. 2013

Clin Vaccine Immunol

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e Influenza virus vaccination is recommended for children, but so far, active vaccination has not been achieved because most parents lack knowledge of vaccine safety and many doctors are reluctant to administer vaccine due to concerns that steroids might alter immunogenicity. The aim of this study was to compare the immunogenicity and safety of inactivated trivalent split influenza virus vaccine between children with recurrent wheezing and healthy children of the same age group. Sixty-eight healthy children and 62 children with recurrent wheezing took part in this study. Seroconversion rates, seroprotection rates, geometric mean titers (GMTs), and geometric mean titer ratios (GMTRs) were measured by a hemagglutination inhibition assay for the assessment of immunogenicity. Solicited and unsolicited local and systemic adverse events were measured for the assessment of safety. Regarding immunogenicity, the seroconversion and seroprotection rates showed no difference overall between healthy children and children with recurrent wheezing. Also, no difference was observed between steroid-treated and nontreated groups with recurrent wheezing. Generally, the GMTs after vaccination were higher in the one-dose vaccination groups for healthy children and children with recurrent wheezing, but the GMTRs revealed different results according to strain in the two groups. Regarding safety, solicited local and systemic adverse events showed no differences between healthy children and children with recurrent wheezing. This study demonstrates that inactivated split influenza virus vaccine is able to induce protective immune responses in healthy children, as observed in previous studies, as well as in children with recurrent wheezing who require frequent steroid treatment.

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Section: Discussionmentioning

confidence: 99%

Immunogenicity and Safety of an Inactivated Trivalent Split Influenza Virus Vaccine in Young Children with Recurrent Wheezing

Bae

Choi

Kwon

et al. 2013

Clin Vaccine Immunol

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“…Bossali et al had made the same remark [11]. However, in Turkey, Ozkaya et al [12] had found a different result. The absence of association between monthly income and immunization status identified in this research work may be due to the fact that costs incurred in performing immunization were not high.…”

Section: Discussionmentioning

confidence: 82%

Social and Health Factors Associated With Children’s Immunization Status in the Local Government of Djougou in Benin in 2013

Noudamadjo¹,

Adédémy²,

Agossou³

et al. 2016

IJTA

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Introduction: In Benin, in recent years, many measles' epidemics had been reported in some local governments, including the municipality of Djougou. Objectives: This study aimed to assess children's immunization status and identify associated social and health factors. Methods: This research work was a cross-sectional, descriptive and analytical study. It had been conducted from 29 to 31 August, 2013 and involved 410 children aged 12 to 23 months and their mothers/minders randomly selected through clustering technique in 30 villages of the Local government of Djougou. Results: Coverages with BCG, DTP1 -Hep1 -Hib1, DTP2 -Hep2 -Hib2, DTP3 -Hep3 -Hib3 and Measles vaccines were respectively 96.30 %, 92.90 %, 89 %, 84.60 % and 72.00 %. Concerning immunization status, 29.02 % of children were not fully vaccinated. Among the factors analyzed, 6 were associated with immunization status. Conclusion: This research work has pointed out that about one out of three selected children was not completely vaccinated. These findings may explain the occurrence of measles epidemics observed in the Local government.

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“…But these conclusions could be misleading as no information about parent refusal to vaccinate their children was given. Spanish studies showed that children with the risk of atopy were inadequately immunized: incompletely or not vaccinated at all because of the social believe that vaccination could cause allergies and asthma (36,37).…”

Section: Vaccination Status and Atopymentioning

confidence: 99%

Relationship between vaccination and atopy

Jagelavičienė¹,

Usonis²

2014

AML

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Background. The rising prevalence of atopic diseases during last decades brings concern for the "Western life-style" countries. Although there is general consensus on the importance of the genetic predisposition for atopic disorders (asthma, allergic rhinitis, atopic dermatitis), only changes in environmental factors can explain the rise of allergic diseases during the last forty years. Vaccinations in infancy have been incriminated as an additional risk factor for development of atopic diseases. A potential relationship between vaccination and atopy could be analysed by two directions: either by activation of the Th2 network in the vaccine-specific memory response, or exposition to (attenuated or inactivated) pathogens or their components at a very young age of vaccinated children and possible promotion of Th1 proliferation. Materials and methods. The major electronic databases (Medline, Cochrane Library) were searched using key words: vaccination, atopy, relationship and children. Recent studies analysing a relationship between atopic disorders and vaccination in infancy were reviewed. Moreover, possible mechanisms of immune response to vaccines in atopic children were analysed. Results. Available evidence is rather convincing that the current regular childhood vaccination does not increase the risk of atopic disorders. Large epidemiological, prospective, cohort and multi-central studies all over the world published in last 10 years with quite large proportions of unvaccinated children included showed that vaccination in infancy was not related to development of atopic conditions starting from the first year of life up to the middle age. Even conversely, some studies detected that vaccinated children had a moderately reduced rate of atopic diseases. It was also denoted that atopy could be suppressed due to high vaccination coverage. Conclusions. Allergic or atopic children just like non-atopic children require routine immunization to be protected from serious life and health threatening viral and bacterial infections. The risks of infection by vaccine avoidance outweigh by far the possible minimal risks of immunization, moreover, anti-infectious treatment or natural infection (like pertussis) per se could be potential triggers of atopic disorders.

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Vaccination coverage and risk factors for incomplete vaccination in children with recurrent wheeze

Abstract: Children under three years of age with recurrent wheeze run a high risk of incomplete immunisation. Efforts should be therefore made to insure that such children receive adequate vaccination.

Cited by 4 publications

References 26 publications

Immunogenicity and Safety of an Inactivated Trivalent Split Influenza Virus Vaccine in Young Children with Recurrent Wheezing

Immunogenicity and Safety of an Inactivated Trivalent Split Influenza Virus Vaccine in Young Children with Recurrent Wheezing

Social and Health Factors Associated With Children’s Immunization Status in the Local Government of Djougou in Benin in 2013

Relationship between vaccination and atopy

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