Biochemical Pharmacology volume 81, issue 9, P1164-1170 2011 DOI: 10.1016/j.bcp.2011.02.004 View full text
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M. Pravetoni, D.E. Keyler, M.D. Raleigh, A.C. Harris, M.G. LeSage, C.K. Mattson, S. Pettersson, P.R. Pentel

Abstract: Preclinical models of nicotine vaccine pharmacology have relied on i.v. or s.c. administration of nicotine. Models using cigarette smoke inhalation might more accurately simulate nicotine exposure in smokers. Nicotine vaccine effects were examined in rats using two cigarette smoke exposure models: a 10 minute nose-only exposure (NSE) producing serum nicotine levels equivalent to the nicotine boost from 1 cigarette in a smoker, and a two hour whole-body exposure (WBE) producing serum nicotine levels similar to…

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