Vaccination Against Measles, Mumps, and Rubella in the Light of Current Epidemic Threats: Unjustified Postponement

Czajka, Hanna; Czajka, S; Dyląg, Katarzyna Anna; Borek, Elżbieta; Kuchar, Ernest

doi:10.1007/5584_2019_344

Cited by 8 publications

(14 citation statements)

References 13 publications

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“…A total of 76 participants from ASP School and FETS were surveyed. The mean participant age was 3.69±5.04 years (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). There were 30 (39.5%) males and 46 (60.5%) females.…”

Section: Resultsmentioning

confidence: 99%

Seroprevalence of Measles, Mumps, and Rubella antibodies among Southwestern Libyan students.

2020

JMR

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Background Measles, Mumps, and Rubella (MMR) are vaccine preventable viral diseases. They cause significant mortality and morbidity worldwide. The seroprevalence data on MMR in Libya is limited. The aim of our study was to assess the immune status and infection susceptibility of primary school children and university students for measles, mumps, and rubella in Libya through a seroprevalence survey. Methods A cross-sectional serosurvey of MMR was conducted in Brack city, Libya among students of at Al-Shoroug Primary School (ASP) and the Faculty of Engineering and Technology, Sabha University (FETS). Results A total of 76 participants were surveyed. The age range was 7-20 years old with a mean of 13.6 years. The overall mumps IgG seropositivity rate was 43.4%. Measles and Mumps IgG levels among children are significantly higher than University students. A high rubella IgG seroprevalence was noticed in female university students. Conclusion The measles and Mumps IgG sharply decreased with time compared to rubella IGg. According to the Libyan program the first and second dose of the MMR vaccine is given at the age of 12and 18 months, respectively. That may not be protective in adult age. A third regular dose could be recommended in the national vaccine program to prevent outbreaks in young adults. Clinical relevance These results can inform the development of future screening programs and contribute to the management of viral infections in schools and universities. Key words Measles, Mumps, Rubella, seroprevalence, seroprotection, immunoglobulin G, Libya

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Section: Resultsmentioning

confidence: 99%

Seroprevalence of Measles, Mumps, and Rubella antibodies among Southwestern Libyan students.

2020

JMR

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“…Since the onset of MMR vaccine administration, the vaccination of individuals with egg allergies has been the subject of controversy (19). Even though many reports have shown that egg-sensitive individuals can safely take the MMR vaccine, their vaccination is still postponed or rejected (20). The vaccine strains of M-M-RII (Merck, West Point, PA), accounting for one of the commonly used MMR vaccines, are grown in chick embryo cells and human diploid cell culture.…”

Section: Discussionmentioning

confidence: 99%

“…concerned about allergic reactions after MMR vaccination. In observational studies, it is stated that concerns are out of place as there are no allergic reactions to egg proteins found in the MMR vaccine (20). The reliability of MMR vaccination in egg-allergic individuals has been assessed in several studies.…”

Section: Discussionmentioning

confidence: 99%

Reassessing the Risks of MMR Vaccination for Egg-Allergic Patients Referred by Healthcare Workers; a Clinical Paradigm

Can

Kural

2019

Iran Red Crescent Med J

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Background: Egg allergy for the Measles-Mumps-Rubella (MMR) vaccine is still the cause of concern for many healthcare workers and families due to reactions such as anaphylaxis. Objectives: This study aimed to reassess the risk of MMR vaccination in infants with egg allergy referred by healthcare workers. Methods: This cross-sectional observational study was performed in a university-affiliated hospital in Istanbul, Turkey, between March 2017 and September 2018. The study patients were one-year-old infants who were candidates for MMR vaccination, and referred to our outpatient allergy clinic by healthcare workers due to egg allergy. The children were diagnosed with egg allergy by a pediatric allergist and then received the MMR vaccine. Results: Among 50 children aged one year, 19 (38%) were female, and 31 (62%) were male. The diagnosis was atopic dermatitis in 29 (58%) patients, urticaria in 18 (36%) patients, angioedema in 2 (4%) patients, and anaphylaxis in one (2%) patient. Fourteen (28%) patients had both egg and cow's milk allergy. Four (8%) patients had egg, cow's milk, and wheat allergy. The total IgE level was 119.80 ± 213.43 IU/mL. Specific IgE levels for egg white were positive in 37 patients. Specific IgE levels for egg white were 15.26 ± 29.64 kU/L. Skin prick test results were positive for egg allergens in 35 patients with a mean diameter of 3.12 ± 2.18 mm for egg yolk and 3.27 ± 2.62 mm for egg white. None of the patients with egg allergy developed anaphylactic reaction and only one patient had urticaria within 5 min after vaccination. There was no correlation between specific IgE levels for egg white and diagnosis of the patients. Conclusions: MMR vaccine administration to children with egg allergy is safe. Life-threatening reactions to the MMR vaccine in patients with egg-allergy are very rare. It seems in cases of hypersensitivity reactions such as acute anaphylaxis events, the MMR vaccine needs to be administered in a hospital under the supervision of a pediatric allergist.

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“…For this reason, initial recommendations on vaccination included special precautions for persons with known or suspected egg protein allergies. However, it was found that there is no cross-reactivity with antigen epitopes that may potentially remain in the vaccine after purification, and that allergic reactions to MMR (or any other vaccine), including anaphylactic shock, are not more frequent in persons allergic to eggs than in the general population (Andersen & Jørgensen, 2013;Sánchez et al, 2018;Kara Elitok et al, 2019;Czajka et al, 2019). For this reason, witholding vaccination from such persons is no longer recommended, and should be discouraged.…”

Section: Egg Allergymentioning

confidence: 99%

Childhood vaccination in the twenty-first century: Parental concerns and challenges for physicians

Janković¹

2019

Arhiv za farmaciju

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Vaccination is one of the most important methods of prevention of infectious disease, saving millions of lives worldwide and protecting people from potentially debilitating complications. It is therefore hailed as one of the greatest advances of science-based medicine of all times. Although repeatedly proven safe and effective, vaccination has been questioned and resented throughout its long history. Vaccine hesitancy and refusal are once again on the rise in this century, due to a complex interplay of numerous factors and circumstances. A decline in childhood vaccination rates has already resulted in resurgence of hitherto eliminated vaccinepreventable diseases in many countries, and is now perceived as a major public health threat. This decline is closely related to increasing spread of misinformation regarding vaccine safety and effectiveness, coupled with a growing anti-vaccine activism. This, among other issues, underscores the need to improve communication between healthcare workers and parents, as well as devise a more comprehensive approach to boosting vaccine confidence, where scientists, physicians, media and the general public all have important roles to play. In this paper, we discuss the phenomenology and causal structure of vaccine hesitancy and refusal, and briefly review some widespread vaccine-related questions of everyday practical importance.

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Vaccination Against Measles, Mumps, and Rubella in the Light of Current Epidemic Threats: Unjustified Postponement

Cited by 8 publications

References 13 publications

Seroprevalence of Measles, Mumps, and Rubella antibodies among Southwestern Libyan students.

Seroprevalence of Measles, Mumps, and Rubella antibodies among Southwestern Libyan students.

Reassessing the Risks of MMR Vaccination for Egg-Allergic Patients Referred by Healthcare Workers; a Clinical Paradigm

Childhood vaccination in the twenty-first century: Parental concerns and challenges for physicians

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