Vaccination against<i>Toxoplasma gondii</i>: an increasing priority for collaborative research?

Innes, Elisabeth A.

doi:10.1586/erv.10.113

Cited by 71 publications

(38 citation statements)

References 13 publications

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“…However, there are frequent reports of eye disease following acquired infection (Innes 2010) and primary infection during pregnancy can result in abortion or severe neonatal malformations (Liu et al 2009). Furthermore, under conditions of immunosuppression, such as those with AIDS, neoplastic disease and transplant recipients, the infection may be reactivated resulting in fatal encephalitis (Yuan et al 2007).…”

Section: Introductionmentioning

confidence: 99%

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A comparative study between excretory/secretory and autoclaved vaccines against RH strain of Toxoplasma gondii in murine models

et al. 2013

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Toxoplasma gondii is an obligate intracellular protozoan that has a major importance in public health, in addition to veterinary medicine. Therefore, the development of an effective vaccine for controlling toxoplasmosis is an important goal. Excretory/secretory antigens (ESA), were previously identified as potential vaccine candidates, proved to play important roles in the pathogenesis and immune escape of the parasite. In addition, autoclaved Toxoplasma vaccine (ATV) is a special type of killed vaccine, recently characterized. The aim of the present work was, to compare between excretory/secretory and ATV against RH strain of T. gondii in mice based on; parasitological and histopathological levels. Tachyzoites were harvested from peritoneal exudates of infected mice and were used for challenge infection and vaccine preparation. BCG was used as an adjuvant. Mice were allocated equally into five groups; they were vaccinated intradermally over the sternum. The results of this study showed that the survival time after challenge, extended up to 16 days in ESA vaccinated group and up to 15 days in autoclaved Toxoplasma vaccinated group. ESA vaccinated group exhibited a profound decrease in parasite load following parasite challenge with a higher percentage of reduction in parasite count in all examined organs than the autoclaved Toxoplasma vaccinated group. The histopathological picture of the liver in both immunized groups, revealed marked reduction in the pathological changes observed as compared to controls, especially in ESA vaccinated group. It was concluded that vaccination with ESA showed more promising results versus ATV, as demonstrated by the survival rate of vaccinated mice, tachyzoites count and histopathological examination.

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Section: Introductionmentioning

confidence: 99%

“…However, once the parasite encysts in the tissues, the drug loses its effectiveness (Coombs and Muller 2002;Innes 2010). Therefore, an obvious long-term goal of many scientists is to develop of an effective vaccine, which would be of great medical and veterinary value (Tan et al 2011).…”

Section: Introductionmentioning

confidence: 99%

A comparative study between excretory/secretory and autoclaved vaccines against RH strain of Toxoplasma gondii in murine models

et al. 2013

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“…Bu hedefler, akut parazitemiyi azaltmak ve konjenital toksoplazmoza karşı korumak, hayvansal gıdalardaki doku kistlerini azaltmak veya önlemek, kedilerde ookist saçılımını azaltmak ve önlemektir. 73,74 Özellikle çiftlik hayvanlarında uygulanan aşılama ile sağlanacak gıda güvenliğine paralel olarak kedilerde de ookist saçılımının önlenmesine yönelik aşı programlarının geliştirilmesi ve uygulanması, çevresel kontaminasyonun önlenmesi amacıyla arzu edilen bir hedeftir. Ancak, topksoplazma enfeksiyonu kedilerde hastalığa yol açmadığı için böyle bir aşının geliştirilmesi için halk sağlığı örgütlerini önemli görevler beklemektedir.…”

Section: Gıda Güvenliğiunclassified

“…Kedi besleyenlerin aşının kullanımı konusunda bilgilendirilmeleri ve toplum sağlığının korunması için aşıların düzenli olarak hayvanlara uygulanması gerektiği konusunda teşvik edilmeleri gerekmektedir. 73 Dünyada konjenital toksoplazmozu, doku kistlerini ve kedilerde ookist saçılımını önlemek için farklı hedeflere yönelik çeşitli aşı çalışmaları devam etmektedir. Özellikle, günümüzde sıklıkla kullanılan S-48 suşu aşısı, koyun ve keçilerde konjenital toksoplazmozun önlenmesinde kullanılmaktadır.…”

Section: Gıda Güvenliğiunclassified

Halk Sağlığı bakışıyla Toxoplasma gondii/Toxoplasma gondii With Public Health’s Perspective

Cevızcı¹,

Bakar²

2015

Türkiye Halk Sağlığı Dergisi

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ÖzetToksoplazmoz dünyada en yaygın zoonoz hastalıklardan birisidir. Son yıllarda yapılan çalışmalar, farklı sağlık sorunlarının ortaya çıkışında da etkenin sorumlu olabileceği yönündedir. Toksoplazmoz gibi zoonoz hastalıkların azaltılmasında, kontrolünde ve bu hastalıklara karşı korunmada her ülkenin ve her bölgenin sosyo-kültürel yapısı gözönüne alınarak çiğ et-sebzemeyve tüketimi, el hijyeni, hayvan besleme alışkanlıklarını gözden geçirecek, tıp ve veteriner bilimlerinin ortak çalışmalarını içeren tek sağlık anlayışına ihtiyaç vardır. Bu yazıda, Dünyada ve Türkiye'de birçok bölgede önemli fakat bir o kadar da göz ardı edilen Toxoplasma gondii epidemiyolojisi ile ilgili güncel bilgilerin sunulması ve enfeksiyondan korunma ve kontrolde önemli olan koruyucu halk sağlığı yaklaşımlarının paylaşılması amaçlanmıştır.Anahtar Kelimeler: Toxoplasma gondii, kediler, zoonoz hastalıklar, korunma. Toxoplasma gondii With Public Health's Perspective AbstractToxoplasma is one of the most widespread zoonotic pathogens in the world. Recent studies focused on this agent show that it may be responsible for the emergence of several different health problems. One approach includes collaborative activities of medical and veterinary sciences, and needs to review consumption of raw meat, vegetables and fruits, hand hygiene and animal feeding habits, taking account of socio-cultural structures of each country and each region for reducing and controlling of zoonotic diseases such as Toxoplasma and protecting against these diseases. The present study presents current data related to the epidemiology of Toxoplasma gondii which is an important but also neglected pathogen/ agent in many regions in Turkey and the world and also to review protective public health approaches to the prevention and control of infections.

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“…As the causative agent of toxoplasmosis, T. gondii can cause serious diseases in pregnant women and immunocompromised individuals, e.g., AIDS patients, tumor sufferers, and those recovering from transplant operations (Kim and Weiss, 2008;Weiss and Dubey, 2009;Silva et al, 2014). Moreover, T. gondii can also result in abortion or congenital toxoplasmosis, especially in livestock, leading to considerable economic losses (Fayer et al, 2004;Dubey et al, 2005;Innes, 2010;McAuley, 2014). Additionally, clonal T. gondii strains have an uneven geographical distribution, which leads to different toxoplasmosis in humans and animals (Sibley and Ajioka, 2008;Robert-Gangneux and Dardé, 2012).…”

Section: Introductionmentioning

confidence: 99%

Sequence variation in ROP8 gene among Toxoplasma gondii isolates from different hosts and geographical localities

Li¹,

Chen²,

Lu³

et al. 2015

Genet. Mol. Res.

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Vaccination againstToxoplasma gondii: an increasing priority for collaborative research?

Cited by 71 publications

References 13 publications

A comparative study between excretory/secretory and autoclaved vaccines against RH strain of Toxoplasma gondii in murine models

A comparative study between excretory/secretory and autoclaved vaccines against RH strain of Toxoplasma gondii in murine models

Halk Sağlığı bakışıyla Toxoplasma gondii/Toxoplasma gondii With Public Health’s Perspective

Sequence variation in ROP8 gene among Toxoplasma gondii isolates from different hosts and geographical localities

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