Vaccination against Furunculosis

Midtlyng, Paul J.

doi:10.1002/9781118806913.ch16

Cited by 16 publications

(17 citation statements)

References 101 publications

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“…Thus, to understand the basis of protective immunity and the molecular mechanisms involved in activation of T‐cell‐mediated immune response (at the transcript level) during immunization of fish using oil‐based vaccines, we investigated gene transcription profile of cytokines indicative of the presence of the different T‐cell subsets Th1/Th2/Treg/Th17, transcription factors for Th1/Th2 and specific T‐cell marker CD8α, prior to and following vaccination with oil‐adjuvanted A. salmonicida subspecies salmonicida or infectious pancreatic necrosis virus (IPNV) in Atlantic salmon. Oil‐adjuvanted vaccines have shown to be effective against furunculosis (Midtlyng ) and IPNV (Hill & Dixon ) in challenge trials.…”

Section: Injection Preparations Administered Into Various Groups Of Fmentioning

confidence: 99%

Vaccination of Atlantic salmon, Salmo salar L., with Aeromonas salmonicida and infectious pancreatic necrosis virus (IPNV) showed a mixed Th1/Th2/Treg response

Kumari¹,

Bøgwald²,

Dalmo³

2013

Journal of Fish Diseases

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Section: Injection Preparations Administered Into Various Groups Of Fmentioning

confidence: 99%

Vaccination of Atlantic salmon, Salmo salar L., with Aeromonas salmonicida and infectious pancreatic necrosis virus (IPNV) showed a mixed Th1/Th2/Treg response

Kumari¹,

Bøgwald²,

Dalmo³

2013

Journal of Fish Diseases

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“…The pathogen , A. salmonicida , is devastating to fish due to the widespread distribution of the bacteria as well as its ability to affect a diversity of freshwater and marine fish. Five subspecies of A. salmonicida have been identified that can manifest the disease furunculosis (Han et al., ; Midtlyng, ). The term “furunculosis” is used to describe a number of disease presentations caused by the five subspecies of A. salmonicida .…”

Section: Introductionmentioning

confidence: 99%

“…smithia, and subsp. pectinolytica (Midtlyng, ). Atypical furunculosis has been found to occur in over 20 species of both farmed and wild fish and is considered to be an “emerging disease” in Atlantic cod, Gadus morhua , Atlantic halibut, Hippoglossus hippoglossus , spotted wolfish, Anarhichas minor , common wolfish, Anarhichas lupus and turbot, Scophthalmus maximus , as well as a number of ornamental fish species (Gudmundsdottir & Bjornsdottir, ).…”

Section: Introductionmentioning

confidence: 99%

Exploring the efficacy of vaccine techniques in juvenile sablefish,Anoplopoma fimbria

et al. 2017

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Wild sablefish, Anoplopoma fimbria, are a valuable commercial species whose populations are declining. Fortunately, sablefish are excellent species for commercial aquaculture. Sablefish raised under high-density conditions in the marine environment require the use of efficacious vaccines to control disease. Sablefish impacted by disease in net pens may have poor flesh quality and high mortality during grow-out. As a result, disease can cause financial hardship for sablefish aquaculture operators.The efficacy of a multivalent vaccine preparation for sablefish, administered either by intraperitoneal (i.p.) injection or by immersion, against atypical and typical Aeromonas salmonicida, the causative agents of atypical and typical furunculosis, respectively, was examined. A. salmonicida can affect sablefish at any age and size.Consequently, an efficacious vaccine that can be appropriately and optimally administered to all life stages is desirable. Sablefish vaccinated by immersion at~1.5 or 4.5 g with a whole-cell multivalent vaccine were not protected against either typical or atypical A. salmonicida. Factors that may have contributed to the ineffectiveness of the immersion vaccine are discussed. By contrast, the relative per cent survival (RPS) or potency of the whole-cell multivalent vaccine injected i.p. in juvenile sablefish at~50 g against typical and atypical A. salmonicida was 94.3% and 81.7% respectively. The high RPS values indicated that the vaccine successfully initiated an immune response in sablefish upon a second encounter with the pathogen.

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“…Immunisation of farmed salmonids (Atlantic salmon and rainbow trout) against typical As using fully licenced oil-adjuvanted injectable vaccines has historically proven successful and is a standard practice [5]. However, immunisation of non-salmonid species against typical and atypical As has been rather challenging [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

A commercial autogenous injection vaccine protects ballan wrasse (Labrus bergylta, Ascanius) againstAeromonas salmonicida vapAtype V

Paredez

Verner-Jeffreys

Papadopoulou

et al. 2020

Preprint

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ABSTRACTAtypical Aeromonas salmonicida (aAs) and Vibrionaceae related species are bacteria routinely recovered from diseased ballan wrasse used as cleaner fish in Atlantic salmon farming. Autogenous multivalent vaccines formulated from these microorganisms are widely used by the industry to protect farmed wrasse despite limited experimental proof that they are primary pathogens. In this study, the components of a commercial multivalent injection wrasse vaccine were tested for infectivity, pathogenicity and virulence via intra peritoneal injection at pre-deployment size (25-50g) and the efficacy of the vaccine for protection against aAs assessed. Injection with 3.5×109, 8×109 1.8×109 and 5×109 cfu/fish of Vibrio splendidus, V. ichthyoenteri, Aliivibrio logeii and A. salmonicida, respectively, did not cause significant mortalities, lesions or clinical signs after a period of 14 days. IP injection with both aAs and Photobacterium indicum successfully reproduced the clinical signs and internal lesions observed during natural outbreaks of the disease. Differences in virulence (LD50 at day 8-post infection of 3.6×106 cfu/fish and 1.6×107 cfu/fish) were observed for two aAs vapA type V isolates. In addition, the LD50 for Photobacterium indicum was 2.2×107 cfu/fish. The autogenous vaccine was highly protective against the two aAs vapA type V isolates after 700-degree days of immunisation. The RPSFINAL values for the first isolate were 95 and 91% at 1×106 cfu/fish and 1×107 cfu/fish, respectively, and 79% at 1×107 cfu/fish for the second isolate tested. In addition, significantly higher anti aAs seral antibodies (IgM), were detected by ELISA in vaccinated fish in contrast with control (mock vaccinated) fish. These results suggest wrasse can be effectively immunised and protected against aAs infection by injection with oil adjuvanted vaccines prepared with inactivated homologous isolates. Further work should assess the efficacy of vaccination against other isolates that have proven to be pathogenic such as aAs type VI and Photobacterium indicum and explore the feasibility of immersion vaccination. In addition, a full characterisation of aAs isolates within the same vapA types should be performed as differences in virulence between vapA type V isolates were observed and partial genome analysis indicated small but potentially important genomic differences in these isolates.

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Vaccination against Furunculosis

Cited by 16 publications

References 101 publications

Vaccination of Atlantic salmon, Salmo salar L., with Aeromonas salmonicida and infectious pancreatic necrosis virus (IPNV) showed a mixed Th1/Th2/Treg response

Vaccination of Atlantic salmon, Salmo salar L., with Aeromonas salmonicida and infectious pancreatic necrosis virus (IPNV) showed a mixed Th1/Th2/Treg response

Exploring the efficacy of vaccine techniques in juvenile sablefish,Anoplopoma fimbria

A commercial autogenous injection vaccine protects ballan wrasse (Labrus bergylta, Ascanius) againstAeromonas salmonicida vapAtype V

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