Vaccinating the vampire bat Desmodus rotundus against rabies

Almeida, Marilene Fernandes de; Martorelli, L.F.A.; Aires, Caroline C.; Barros, Rodrigo Fernandes de; Massad, Eduardo

doi:10.1016/j.virusres.2008.07.024

Cited by 44 publications

(41 citation statements)

References 11 publications

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“…Rabies can cause the death of wild mammals, including carnivores and ungulates (e.g. MacDonald 1993, Bengis et al 2008, and domestic species, leading to heavy economic losses as result of herd infection and death of livestock (Almeida et al 2008). We highlighted that diseases transmitted between wild and domestic species can be bidirectional, as in the case of rabies, and may be fatal for both groups and with potential for transmission to humans (Bengis et al 2008).…”

Section: Resultsmentioning

confidence: 99%

“…For this reason, it is important to maintain the vaccination of cattle and other domestic animals in areas subject to the presence of Common Vampire Bats, both for domestic animal welfare and for the protection and conservation of wildlife. In addition, it can be done the vaccinating of Desmodus rotundus against rabies applying a paste mixed with oral vaccine on the back of captured animals to indirectly protect other bats from the same colony (Almeida et al 2008). The Lowland Tapir is classified as Vulnerable to extinction at global level (IUCN 2016) contamination of the remaining populations of Lowland Tapir with rabies virus even more serious, particularly in Espírito Santo.…”

Section: Resultsmentioning

confidence: 99%

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Common Vampire Bat (Desmodus rotundus) feeding on Lowland Tapir (Tapirus terrestris) in an Atlantic Forest remnant in southeastern Brazil

Gnocchi

Srbek‐Araujo

2017

Biota Neotrop.

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There are few studies on the diet of Common Vampire Bat (Desmodus rotundus), despite its wide geographic distribution. The species is considered exclusively hematophagous, and medium and large-sized mammals are their main prey. In this study we report evidences of Common Vampire Bat feeding on Lowland Tapir (Tapirus terrestris) in a protected area located in the north of the state of Espírito Santo, southeastern Brazil, from camera trap records. The bat tried to access the Lowland Tapir by the posterior dorsolateral side of the body, and used the mean stratum of the vegetation as a point of support and observation between the consecutive offensives on the prey. In the same reserve, there were also two events of bat offensives on domesticated ox (Bos sp.). But in these cases the attacks occurred from the scapular region of the prey. The record here reported represents the first documented attack of Desmodus rotundus on Tapirus terrestris in the Brazilian Atlantic Forest and one of the first records in the South America as a whole. Previous records were in the Pantanal (Brazil) and in the Amazon rainforest (Ecuador). The feeding on wild and domestic prey by Desmodus rotundus in the same locality may favor the transmission of rabies to populations of wild mammals, as well as to domestic animals, and may represent an economic and public health issue with negative effects also for wildlife.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Common Vampire Bat (Desmodus rotundus) feeding on Lowland Tapir (Tapirus terrestris) in an Atlantic Forest remnant in southeastern Brazil

Gnocchi

Srbek‐Araujo

2017

Biota Neotrop.

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“…Rabies control efforts in Guatemala are focused primarily on mass vaccination of domestic dogs, which has led to a significant decrease in human rabies cases, though it remains unclear whether current efforts can achieve ultimate elimination of canine rabies [21], [51]. Indirect vaccination of vampire bats with recombinant RABV vaccines have proven immunogenic and efficacious in experimental infection models of D. rotundus , though this strategy has not been tested in the field [52]. Despite possibly reducing RABV infection of cattle, this strategy would not eliminate the behavior or health and economic consequences (e.g.…”

Section: Discussionmentioning

confidence: 99%

Bat Rabies in Guatemala

et al. 2014

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Rabies in bats is considered enzootic throughout the New World, but few comparative data are available for most countries in the region. As part of a larger pathogen detection program, enhanced bat rabies surveillance was conducted in Guatemala, between 2009 and 2011. A total of 672 bats of 31 species were sampled and tested for rabies. The prevalence of rabies virus (RABV) detection among all collected bats was low (0.3%). Viral antigens were detected and infectious virus was isolated from the brains of two common vampire bats (Desmodus rotundus). RABV was also isolated from oral swabs, lungs and kidneys of both bats, whereas viral RNA was detected in all of the tissues examined by hemi-nested RT-PCR except for the liver of one bat. Sequencing of the nucleoprotein gene showed that both viruses were 100% identical, whereas sequencing of the glycoprotein gene revealed one non-synonymous substitution (302T,S). The two vampire bat RABV isolates in this study were phylogenetically related to viruses associated with vampire bats in the eastern states of Mexico and El Salvador. Additionally, 7% of sera collected from 398 bats demonstrated RABV neutralizing antibody. The proportion of seropositive bats varied significantly across trophic guilds, suggestive of complex intraspecific compartmentalization of RABV perpetuation.

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“…Usually, prophylactic vaccination has emerged with the use of lyophilised SAG2 and V-RG vaccines to immunise dogs, raccoons, skunks, bats, and foxes as reported by Rupprecht et al (1986), Fekadu et al (1996, Lambot et al (2001), and Follmann et al (2004). Although the use of similar methodology has been attempted in vampire bat (Almeida et al 2005;Almeida et al 2008) with partial success, no comercial product is available in the Brazilian, or South American markets with this intent. The present study complemented the previous initiatives to produce an effective and viable bat vaccine, modifying also the vaccine delivering paste.…”

Section: Resultsmentioning

confidence: 99%

Immune response after rabies oral immunization in mice

Silva

Krüger

Agottani

et al. 2013

Braz. arch. biol. technol.

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The objective of this study was to formulate an anti-rabies oral vaccine from the cell culture vaccine PV TECPAR to elicit the production of antibodies against the rabies in mice. A vaccine was developed using 10 7.5 DL 50 /0.03 ml viral antigens homogenised in lanovaseline to facilitate oral administration. Mice were vaccinated two times for seroconversion. Sera of the vaccinated mice showed a higher level of antibody production than the control group. These results could be used to direct the development of an anti-rabies oral vaccine.

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Vaccinating the vampire bat Desmodus rotundus against rabies

Cited by 44 publications

References 11 publications

Common Vampire Bat (Desmodus rotundus) feeding on Lowland Tapir (Tapirus terrestris) in an Atlantic Forest remnant in southeastern Brazil

Common Vampire Bat (Desmodus rotundus) feeding on Lowland Tapir (Tapirus terrestris) in an Atlantic Forest remnant in southeastern Brazil

Bat Rabies in Guatemala

Immune response after rabies oral immunization in mice

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