Vaccenic acid favourably alters immune function in obese JCR:LA- cp rats

Blewett, Heather; Gerdung, Christopher A.; Ruth, Megan R.; Proctor, Spencer D.; Field, Catherine J.

doi:10.1017/s0007114509231722

Cited by 80 publications

(68 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[38] There are insufficient human studies to support an anti-inflammatory role of cis-VA. However, similar to animal model data, [30] a study with 1373 healthy men associated high levels of cis-VA in erythrocyte membranes with high concentrations of the anti-inflammatory peptide adiponectin [39] (Table 2).…”

Section: Palmitoleic Acid Elongation Product In Metabolic Diseasesupporting

confidence: 66%

“…[3,11] Furthermore, palmitoleic acid-treated cells showed an increase of cis-vaccenic acid (VA, 18:1n-7), [25,27] which itself induces several immunemetabolic effects. [28][29][30] Studies with cis-VA are summarized in Table 2.…”

Section: Palmitoleic Acid Elongation Product In Metabolic Diseasementioning

confidence: 99%

“…[28,30] Lean and obese rats fed with cis-VA presented lower proportions of T cells and production of IL-2 and tumor necrosis factor (TNF) α in their mesenteric lymph nodes. [30] Similarly, obese JCR:LA-cp (James C. Russell:LA corpulent rat strain) rats fed a high cis-VA diet showed a reduction in hepatic ectopic lipid accumulation and a lower expression of TNF-α and IL-1β in the intestinal mucosa. [38] There are insufficient human studies to support an anti-inflammatory role of cis-VA.…”

Section: Palmitoleic Acid Elongation Product In Metabolic Diseasementioning

confidence: 99%

“…Animal studies [30] Lean (2:1 mix of +/cp and +/+) and obese (cp/cp) JCR:LA-cp rats, fed 3-week a control diet (0% VA) or a VA diet (1.5% w/w) VA was ↑ in plasma phospholipids versus control-fed rats Lean VA-fed rats: ↓ proportions of CD45RC+ helper cells, and T-helper cells ↓ IL-2, IL-10, and TNF-α in spleen Obese VA-fed rats: normalized IL-2 and TNF-α in MLN to those seen in lean rats [35] LDLr −/− mice fed 14-week with atherogenic diet (2% cholesterol) (CH) or 15% vaccenic butter (1.5% w/w VA) (VB) CH + VB: ↓ serum cholesterol and triglyceride levels, ↓ atherosclerosis [34] Spontaneously hypertensive rats fed 7-week with AMF (rich in VA and CLA), or AMF + sterculic oil (SO; which inhibits the conversion of VA into CLA)…”

Section: Reference Experimental or Clinical Model Major Findingsmentioning

confidence: 99%

See 3 more Smart Citations

Is Palmitoleic Acid a Plausible Nonpharmacological Strategy to Prevent or Control Chronic Metabolic and Inflammatory Disorders?

Souza

Vannice²,

Neto

et al. 2017

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Although dietary fatty acids can modulate metabolic and immune responses, the effects of palmitoleic acid (16:1n-7) remain unclear. Since this monounsaturated fatty acid is described as a lipokine, studies with cell culture and rodent models have suggested it enhances whole body insulin sensitivity, stimulates insulin secretion by β cells, increases hepatic fatty acid oxidation, improves the blood lipid profile, and alters macrophage differentiation. However, human studies report elevated blood levels of palmitoleic acid in people with obesity and metabolic syndrome. These findings might be reflection of the level or activity of stearoyl-CoA desaturase-1, which synthesizes palmitoleate and is enhanced in liver and adipose tissue of obese patients. The aim of this review is to describe the immune-metabolic effects of palmitoleic acid observed in cell culture, animal models, and humans to answer the question of whether palmitoleic acid is a plausible nonpharmacological strategy to prevent, control, or ameliorate chronic metabolic and inflammatory disorders. Despite the beneficial effects observed in cell culture and in animal studies, there are insufficient human intervention studies to fully understand the physiological effects of palmitoleic acid. Therefore, more human-based research is needed to identify whether palmitoleic acid meets the promising therapeutic potential suggested by the preclinical research.

show abstract

Section: Palmitoleic Acid Elongation Product In Metabolic Diseasesupporting

confidence: 66%

Section: Palmitoleic Acid Elongation Product In Metabolic Diseasementioning

confidence: 99%

Section: Palmitoleic Acid Elongation Product In Metabolic Diseasementioning

confidence: 99%

Section: Reference Experimental or Clinical Model Major Findingsmentioning

confidence: 99%

See 2 more Smart Citations

Is Palmitoleic Acid a Plausible Nonpharmacological Strategy to Prevent or Control Chronic Metabolic and Inflammatory Disorders?

Souza

Vannice²,

Neto

et al. 2017

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

“…VA is a precursor of CLA synthesis in mammary gland, and hence dietary VA may contribute to the amount of CLA available to the human body. There is also an evidence that dietary VA favourably alters the pro-inflammatory tendency of mesenteric lymphocytes from JCR:LA-cp rats (Blewett et al, 2009). VA was also shown to increase the serum level of C18:2 c9 t11 CLA in humans (Salminen et al, 1998;Turpeinen et al, 2002).…”

mentioning

confidence: 94%

Enhancing unsaturated fatty acids in ewe's milk by feeding rapeseed or linseed oil

Cieślak¹,

Kowalczyk²,

Czauderna³

et al. 2010

CZECH J ANIM SCI

View full text Add to dashboard Cite

The aim of our research was to evaluate whether rapeseed and linseed oils used as feed additives to ewe's diets allow to achieve the higher secretion of unsaturated fatty acids into milk with extended emphasis on the conjugated linoleic acid concentration. Two experiments were carried out on 6 lactating ewes in two independent 3 × 3 Latin square designs. In each feeding cycle the animals were subjected to one of the treatments: (1) without oil supplementation, (2) with 3.5% of rapeseed oil (RS) or linseed oil (LS), (3) with 7.0% of rapeseed oil or linseed oil. Feeding diets rich in mono- and polyunsaturated fatty acids to lactating ewes under our experimental conditions resulted in demanded changes in milk fatty acid content without causing milk fat depression or modification of other milk constituents. Milk fat was improved in unsaturated fatty acids including C18:2 c9 t11 CLA isomer without changing the milk fat concentration. The C18:2 c9 t11 concentration increased from 0.03 (FAME, %) in the control group to 0.21 and 0.12 (FAME, %) in groups receiving 3.5 and 7% RS, respectively. The diet with 7% LS also elevated the C18:2 c9 t11 level in milk from 0.04 (FAME, %) in the control group to 0.11 (FAME, %). Hence a conclusion is drawn that plant oils may be an important source of monoenic and also polyenic fatty acids in milk, however, our research and analysis of literature data indicate that results are strictly dietary and supplement-dependent.

show abstract

RuminantTransFat as Potential Nutraceutical Components to Prevent Cancer and Cardiovascular Disease

Wang¹,

Field²,

Proctor³

2011

Functional Foods, Nutraceuticals, and Degenerative Disease Prevention

View full text Add to dashboard Cite

Vaccenic acid favourably alters immune function in obese JCR:LA- cp rats

Cited by 80 publications

References 50 publications

Is Palmitoleic Acid a Plausible Nonpharmacological Strategy to Prevent or Control Chronic Metabolic and Inflammatory Disorders?

Is Palmitoleic Acid a Plausible Nonpharmacological Strategy to Prevent or Control Chronic Metabolic and Inflammatory Disorders?

Enhancing unsaturated fatty acids in ewe's milk by feeding rapeseed or linseed oil

RuminantTransFat as Potential Nutraceutical Components to Prevent Cancer and Cardiovascular Disease

Contact Info

Product

Resources

About