Vacata- and divacataporphyrin: New photosensitizers for application in photodynamic therapy-an in vitro study

Klyta, Magdalena; Ostasiewicz, Paweł; Jurczyszyn, Kamil; Duś, Kamila; Latos‐Grażyński, Lechosław; Pacholska‐Dudziak, Ewa; Ziółkowski, Piotr

doi:10.1002/lsm.21086

Cited by 9 publications

(7 citation statements)

References 23 publications

(23 reference statements)

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“…Ce6 is a monomer compound which consists of single chemical structure. Previous studies showed that Ce6 can be selectively accumulated in tumor tissues and rapidly cleared from the normal tissues 44 . Li et al 45 observed that Ce6 mediated SDT can activate the mitochondrial-dependent apoptosis pathway in human chronic myelogenous leukemia K562 cells.…”

Section: Sonosensitizersmentioning

confidence: 99%

Recent advances of sonodynamic therapy in cancer treatment

Wan

Liu²,

Chen

et al. 2016

Cancer Biology &Amp; Medicine

228

157

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Sonodynamic therapy (SDT) is an emerging approach that involves a combination of low-intensity ultrasound and specialized chemical agents known as sonosensitizers. Ultrasound can penetrate deeply into tissues and can be focused into a small region of a tumor to activate a sonosensitizer which offers the possibility of non-invasively eradicating solid tumors in a site-directed manner. In this article, we critically reviewed the currently accepted mechanisms of sonodynamic action and summarized the classification of sonosensitizers. At the same time, the breath of evidence from SDT-based studies suggests that SDT is promising for cancer treatment.

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Section: Sonosensitizersmentioning

confidence: 99%

Recent advances of sonodynamic therapy in cancer treatment

Wan

Liu²,

Chen

et al. 2016

Cancer Biology &Amp; Medicine

228

157

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“…After di-imide reduction, disulfonated tetraphenyl porphine [TPPS(2a)] was transferred into disulfonated tetraphenyl chlorin [TPCS(2a)] for better induced activation of gelonin, which delayed tumor growth in athymic mice on subcutaneous irradiation [ 22 ]. There is a possibility that most new porphyrins are excited at a higher wavelength illumination; therefore, a deeper light penetration of photosensitizer is needed for further studies [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Porphyrin photosensitizers in photodynamic therapy and its applications

2017

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In 1841, the extraction of hematoporphyrin from dried blood by removing iron marked the birth of the photosensitizer. The last twenty years has witnessed extensive research in the application of photodynamic therapy (PDT) in tumor-bearing (or other diseases) animal models and patients. The period has seen development of photosensitizers from the first to the third generation, and their evolution from simple to more complex entities. This review focuses on porphyrin photosensitizers and their effect on tumors, mediated via several pathways involved in cell necrosis, apoptosis or autophagic cell death, and the preventive and therapeutic application of PDT against atherosclerosis.

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“…Chlorin e6, owing to the photosensitizer character has been widely used in the area of photodynamic treatment, including clinical studies [21,22]. Sharing the same mechanism with PDT, sonosensitizer exposed to ultrasound sonication generated reactive oxygen species (ROS) [23], which results in destroying bacteria.…”

Section: Discussionmentioning

confidence: 99%