vacA genotypes of Helicobacter pylori in the oral cavity and stomach of patients with chronic gastritis and gastric ulcer

Román-Román, Adolfo; Cerezo, Silvia Giono; Camorlinga‐Ponce, Margarita; Martínez‐Carrillo, Dinorah Nashely; Loaiza-Loeza, Salome; Fernández‐Tilapa, Gloria

doi:10.1016/j.eimc.2012.09.002

Cited by 30 publications

(29 citation statements)

References 23 publications

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“…Some authors, in agreement with the findings here presented, reported about a low correlation between the gastric infection and the presence of cagA+ genotype in oral cavity (31) . Although there are several genes associated with adhesion of the bacteria, the babA2 gene is associated with successful colonization (21) .…”

Section: Discussionsupporting

confidence: 81%

“…Similarly, this association was observed in 13.3% of gastric samples from patients suffering chronic gastritis as reported by Paniagua et al (27) . Regarding the coincidence between the same genotype in oral cavity and gastric mucosa, the genotypes found in saliva and biopsy of the same patient had 51.1% agreement (31) . Other studies show that people can be infected simultaneously by two or more genotypes of H. pylori (22) , due to coinfection or genetic variation (24) .…”

Section: Discussionmentioning

confidence: 99%

“…Not always H. pylori is found simultaneously in oral cavity and in gastric samples. Román-Román et al found H. pylori DNA in saliva and in biopsy in 24% of patients,52.5% were saliva negative/ biopsy positive and 6.6% were saliva positive/biopsy negative (31) . Berroteran et al investigated H. pylori presence in dental plaque from dyspeptic patients (4) .…”

Section: Discussionmentioning

confidence: 99%

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Correlation between virulence markers of Helicobacter pylori in the oral cavity and gastric biopsies

Medina¹,

Medina

Merino

2017

Arq. Gastroenterol.

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-Background -The clinical outcome of Helicobacter pylori infection has been associated with virulence factors. The presence of these factors is useful as molecular markers in the identification of the high risk for developing severe gastric pathologies. Objective -To correlate the presence of virulence markers cagA and bab2A of H. pylori in oral and gastric biopsy samples. Methods -An observational, prospective, descriptive, and cross-sectional study was carried out between September 2011 and September 2012. Patients suffering dyspepsia with indication for upper gastrointestinal video endoscopy who attended the Gastroenterology Service of the Hospital Dr. Julio C. Perrando were included. Epidemiological investigation was completed. To detect the bacteria and their virulence genes, samples of saliva, dental plaque and gastric biopsy were taken and processed by PCR.Results -Sixty-one patients were selected for this study (30 women and 31 men). H. pylori was detected in 31 gastric biopsies and 31 oral samples.Significant difference between oral and gastric samples was found in cagA genotype. Agreement between oral and gastric genotypes was found in 38.7% of samples from the same patient. Conclusion -This study is the first in provide information about the genotypes of the Argentinean Northeast H. pylori strains. Despite the high prevalence of H. pylori infection, the most of patients had less virulent genotypes in oral cavity and gastric tissue. The cagA/babA2 combination was not frequent in the samples studied. There was not a statistical correlation between the virulence genes and gastroduodenal or oral diseases. Although in some patients the same genotype was found both in oral and gastric samples, it cannot be ensure that they corresponding to the same strain because a DNA sequencing was not performed.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Correlation between virulence markers of Helicobacter pylori in the oral cavity and gastric biopsies

Medina¹,

Medina

Merino

2017

Arq. Gastroenterol.

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“…Several investigators have detected H. pylori in dental plaque and saliva, and also showed that periodontal pockets ! 5 mm in depth are associated with increased odds of H. pylori seropositivity (43)(44)(45)(46). Therefore, long-term H. pylori infection is considered to cause not only gastric mucosal atrophy, but also periodontitis.…”

Section: Discussionmentioning

confidence: 99%

A Study on the Relationship between Reflux Esophagitis and Periodontitis

et al. 2016

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Objective Metabolic syndrome and dental erosion have been demonstrated to correlate with gastroesophageal acid reflux disease (GERD), while periodontitis has been reported to have a positive relationship with metabolic syndrome. However, no correlation between periodontitis and GERD has yet been reported. We therefore investigated the relationship between periodontitis and GERD. Methods The subjects consisted of 280 individuals who visited the Health Center for a detailed medical checkup examination. Each underwent upper endoscopy and periodontitis examinations, with the latter performed by measuring the concentrations of lactate dehydrogenase and hemoglobin in saliva. The subjects were divided into those with positive and negative periodontitis findings, and the prevalence rates of endoscopically proven reflux esophagitis, dyslipidemia, hypertension, and hyperglycemia were compared. Results The number of subjects positive for periodontitis was 93, while 187 had negative findings. The prevalence of reflux esophagitis was not different between the positive and negative groups (8.6% vs. 8.0%). In addition, a multiple logistic regression analysis did not identify a positive relationship between the presence of periodontitis and reflux esophagitis. On the other hand, dyslipidemia and hypertension were more frequently observed in the subjects that were positive for periodontitis. Conclusion We did not find an association between periodontitis and reflux esophagitis in the present study. On the other hand, the presence of periodontitis was found to correlate with hypertension and dyslipidemia.

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“…Los oligonucleótidos empleados en la PCR usada en este estudio para revelar el gen RNAr 16S de H. pylori permiten detectar 2.5 ng de ADN de la bacteria en 50 o 150 ng de ADN humano y discriminan entre el gen RNAr 16S de H. pylori con el de Campylobacter spp. y el de otras bacterias aisladas de la mucosa gástrica 29 . El uso de la PCR múltiple permitió obtener el genotipo bacteriano en un menor tiempo, disminuir el gasto de reactivos y agilizar la entrega de resultados a los pacientes.…”

Section: Discussionunclassified

Diversidad de los genotipos vacA y cagA de Helicobacter pylori y expresión de interferón gamma en pacientes con gastritis crónica y cáncer gástrico

Martínez‐Carrillo¹,

Atrisco-Morales²,

Hernández-Pando³

et al. 2014

Revista de Gastroenterología de México

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vacA genotypes of Helicobacter pylori in the oral cavity and stomach of patients with chronic gastritis and gastric ulcer

Cited by 30 publications

References 23 publications

Correlation between virulence markers of Helicobacter pylori in the oral cavity and gastric biopsies

Correlation between virulence markers of Helicobacter pylori in the oral cavity and gastric biopsies

A Study on the Relationship between Reflux Esophagitis and Periodontitis

Diversidad de los genotipos vacA y cagA de Helicobacter pylori y expresión de interferón gamma en pacientes con gastritis crónica y cáncer gástrico

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