VAAMANA—a BEL1-like homeodomain protein, interacts with KNOX proteins BP and STM and regulates inflorescence stem growth in Arabidopsis

Bhatt, Anuj M.; Etchells, J. Peter; Canales, Claudia; Lagodienko, Andrey; Dickinson, H. G.

doi:10.1016/j.gene.2003.12.033

Cited by 149 publications

(196 citation statements)

References 27 publications

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“…KNOX proteins interact with another group of TALE proteins, the BEL1-like homeodomain family (BELL or BLH, see Table 2), in a highly connected, complex network that determines not only high-affinity KNOX target selection but also their subcellular localization (Bellaoui et al, 2001;Bhatt et al, 2004;Cole et al, 2006;Hackbusch et al, 2005;Smith et al, 2002). These interactions depend on the KNOX MEINOX domain, and each homeodomain of the two proteins binds to target DNA as a protein heterodimer (Box 3).…”

Section: Knox-bell Protein Interactionsmentioning

confidence: 99%

KNOX genes: versatile regulators of plant development and diversity

2010

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SummaryKnotted1-like homeobox (KNOX) proteins are homeodomain transcription factors that maintain an important pluripotent cell population called the shoot apical meristem, which generates the entire above-ground body of vascular plants. KNOX proteins regulate target genes that control hormone homeostasis in the meristem and interact with another subclass of homeodomain proteins called the BELL family. Studies in novel genetic systems, both at the base of the land plant phylogeny and in flowering plants, have uncovered novel roles for KNOX proteins in sculpting plant form and its diversity. Here, we discuss how KNOX proteins influence plant growth and development in a versatile context-dependent manner.

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Section: Knox-bell Protein Interactionsmentioning

confidence: 99%

KNOX genes: versatile regulators of plant development and diversity

2010

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“…Given the proposed role of KNOX in leaf proximal-distal patterning, we investigated genes that are DE in our data and are also bound and modulated by KN1 protein (Bolduc et al, 2012b). In Arabidopsis, BEL1-like homeodomain (BELL) proteins form heterodimers with KNOX proteins in combinations that determine target selection and subcellular localization (Bellaoui Smith et al, 2002;Bhatt et al, 2004;Hackbusch et al, 2005;Cole et al, 2006). Our data show that maize bel12 (GRMZM2G154641) is significantly upregulated in the preligule region, whereas bel14 (GRMZM2G125976) is expressed at low levels in the blade, moderate levels in the sheath, and most highly in the ligule region ( Figure 4G; Supplemental Table 4).…”

Section: Ligule Genes Are Expressed At Multiple Organ Boundariesmentioning

confidence: 99%

Transcriptomic Analyses Indicate That Maize Ligule Development Recapitulates Gene Expression Patterns That Occur during Lateral Organ Initiation

et al. 2014

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Development of multicellular organisms proceeds via the correct interpretation of positional information to establish boundaries that separate developmental fields with distinct identities. The maize (Zea mays) leaf is an ideal system to study plant morphogenesis as it is subdivided into a proximal sheath and a distal blade, each with distinct developmental patterning. Specialized ligule and auricle structures form at the blade-sheath boundary. The auricles act as a hinge, allowing the leaf blade to project at an angle from the stem, while the ligule comprises an epidermally derived fringe. Recessive liguleless1 mutants lack ligules and auricles and have upright leaves. We used laser microdissection and RNA sequencing to identify genes that are differentially expressed in discrete cell/tissue-specific domains along the proximal-distal axis of wild-type leaf primordia undergoing ligule initiation and compared transcript accumulation in wild-type and liguleless1-R mutant leaf primordia. We identified transcripts that are specifically upregulated at the blade-sheath boundary. A surprising number of these "ligule genes" have also been shown to function during leaf initiation or lateral branching and intersect multiple hormonal signaling pathways. We propose that genetic modules utilized in leaf and/or branch initiation are redeployed to regulate ligule outgrowth from leaf primordia.

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“…pny mutants are characterized by phyllotaxy defects, partial loss of apical dominance, and reduced stature (Byrne et al, 2003;Roeder et al, 2003;Smith and Hake, 2003;Bhatt et al, 2004). In addition, the pny mutant shows fruit alterations, such as defects in replum differentiation and in septum fusion (Byrne et al, 2003;Roeder et al, 2003).…”

Section: The Inactivation Of Knat6 Rescues the Pny Phenotypementioning

confidence: 99%

“…BP plays a primary role in inflorescence growth, as indicated by bp mutants that exhibit reduced internode and pedicel lengths, bends at nodes, and downward-oriented siliques (Douglas et al, 2002;Venglat et al, 2002;Smith and Hake, 2003). PNY influences inflorescence architecture and fruit development (Byrne et al, 2003;Smith and Hake, 2003;Bhatt et al, 2004). PNY also interacts with BP to regulate inflorescence patterning and fruit development (Smith and Hake, 2003;Alonso-Cantabrana et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Interaction ofKNAT6andKNAT2withBREVIPEDICELLUSandPENNYWISEinArabidopsisInflorescences

et al. 2008

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The three amino acid loop extension (TALE) homeodomain superfamily, which comprises the KNOTTED-like and BEL1-like families, plays a critical role in regulating meristem activity. We previously demonstrated a function for KNAT6 (for KNOTTED-like from Arabidopsis thaliana 6) in shoot apical meristem and boundary maintenance during embryogenesis. KNAT2, the gene most closely related to KNAT6, does not play such a role. To investigate the contribution of KNAT6 and KNAT2 to inflorescence development, we examined their interactions with two TALE genes that regulate internode patterning, BREVIPEDICELLUS (BP) and PENNYWISE (PNY). Our data revealed distinct and overlapping interactions of KNAT6 and KNAT2 during inflorescence development. Removal of KNAT6 activity suppressed the pny phenotype and partially rescued the bp phenotype. Removal of KNAT2 activity had an effect only in the absence of both BP and KNAT6 or in the absence of both BP and PNY. Consistent with this, KNAT6 and KNAT2 expression patterns were enlarged in both bp and pny mutants. Thus, the defects seen in pny and bp are attributable mainly to the misexpression of KNAT6 and to a lesser extent of KNAT2. Hence, our data showed that BP and PNY restrict KNAT6 and KNAT2 expression to promote correct inflorescence development. This interaction was also revealed in the carpel.

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VAAMANA—a BEL1-like homeodomain protein, interacts with KNOX proteins BP and STM and regulates inflorescence stem growth in Arabidopsis

Cited by 149 publications

References 27 publications

KNOX genes: versatile regulators of plant development and diversity

KNOX genes: versatile regulators of plant development and diversity

Transcriptomic Analyses Indicate That Maize Ligule Development Recapitulates Gene Expression Patterns That Occur during Lateral Organ Initiation

Interaction ofKNAT6andKNAT2withBREVIPEDICELLUSandPENNYWISEinArabidopsisInflorescences

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