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Green, Paige; Williams, Rosemary; Dawkins, Fitzroy W.; Adams‐Campbell, Lucile L.

doi:10.1023/a:1016337102256

Cited by 40 publications

(11 citation statements)

References 38 publications

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“…With all-cause mortality as the endpoint seven studies reported no association (Ewertz et al , 1991; Zhang et al , 1995; Holmes et al , 1999; Saxe et al , 1999; McEligot et al , 2006; Franceschi et al , 2009; Kwan et al , 2010) and four studies reported an inverse association between alcohol consumption and overall survival (Barnett et al , 2008; Reding et al , 2008; Beasley et al , 2010; Flatt et al , 2010). In contrast, when the endpoint was breast cancer-specific mortality or breast cancer recurrence, two studies reported no association (Rohan et al , 1993; Goodwin et al , 2003), while four studies reported an increase in risk with increasing alcohol consumption (Hebert et al , 1998; Green McDonald et al , 2002; Beasley et al , 2010; Kwan et al , 2010). We observed no significant association between alcohol intake and breast cancer-specific mortality, although there was the suggestion of an increased risk among the small number of women consuming 10 g per day (corresponding to approximately 0.75 to 1 drink/day) or more (HR=1.36; 95% CI 0.82–2.26) (Suzuki et al , 2005).…”

Section: Discussionmentioning

confidence: 92%

“…(Ewertz et al , 1991; Zhang et al , 1995; Holmes et al , 1999; Saxe et al , 1999; McEligot et al , 2006; Franceschi et al , 2009; Kwan et al , 2010). When breast cancer-specific outcomes have been examined, four studies have reported an increased risk with breast cancer-specific mortality or recurrence (Hebert et al , 1998; Green McDonald et al , 2002; Beasley et al , 2010; Kwan et al , 2010), and two studies reported no association (Rohan et al , 1993; Goodwin et al , 2003). Given these inconclusive results, the aim of this study was to investigate whether pre-diagnosis alcohol intake was associated with breast cancer-specific and overall survival among women with invasive breast cancer in the population-based Swedish Mammography Cohort (SMC).…”

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confidence: 99%

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Alcohol intake and mortality among women with invasive breast cancer

Harris

Bergkvist²,

Wolk

2012

Br J Cancer

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Background:Alcohol intake has consistently been associated with increased breast cancer incidence in epidemiological studies. However, the relation between alcohol and survival after breast cancer diagnosis is less clear.Methods:We investigated whether alcohol intake was associated with survival among 3146 women diagnosed with invasive breast cancer in the Swedish Mammography Cohort. Alcohol consumption was estimated using a food frequency questionnaire. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs).Results:From 1987 to 2008 there were 385 breast cancer-specific deaths and 860 total deaths. No significant association was observed between alcohol intake and breast cancer-specific survival. Women who consumed 10 g per day (corresponding to approximately 0.75 to 1 drinks) or more of alcohol had an adjusted HR (95% CI) of breast cancer-specific death of 1.36 (0.82–2.26;ptrend=0.47) compared with non-drinkers. A significant inverse association was observed between alcohol and non-breast cancer deaths. Those who consumed 3.4–9.9 g per day of alcohol had a 33% lower risk of death compared with non-drinkers (95% CI 0.50–0.90;ptrend=0.04).Conclusion:Our findings suggest that alcohol intake up to approximately one small drink per day does not negatively impact breast cancer-specific survival and a half drink per day is associated with a decreased risk of mortality from other causes.

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Section: Discussionmentioning

confidence: 92%

mentioning

confidence: 99%

Alcohol intake and mortality among women with invasive breast cancer

Harris

Bergkvist²,

Wolk

2012

Br J Cancer

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“…Of the 11 studies that reported on BCSS, six studies reported no association (1, 12, 14, 18, 20, 22) and four studies reported that increased alcohol intake was associated with increased breast cancer-specific mortality (2, 7, 19, 21). The reporting of alcohol consumption in these studies was very heterogeneous.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, it was not possible to combine estimates in a formal meta-analysis. One study did not report details about levels of exposure (12), one study did not use non- or minimal drinkers as a reference group (20), and two studies modeled alcohol intake as a continuous variable (19, 21). Both of these reported that alcohol consumption was associated with a poorer prognosis, but the sample sizes were small and in one, the effect was limited to beer drinkers (19).…”

Section: Resultsmentioning

confidence: 99%

Alcohol Consumption and Survival after a Breast Cancer Diagnosis: A Literature-Based Meta-analysis and Collaborative Analysis of Data for 29,239 Cases

Ali

Schmidt

Bolla

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Evidence for an association of alcohol consumption with prognosis after a diagnosis of breast cancer has been inconsistent. We have reviewed and summarized the published evidence and evaluated the association using individual patient data from multiple case cohorts. Methods A MEDLINE search to identify studies published up to January 2013 was performed. We combined published estimates of survival time for “moderate drinkers” versus nondrinkers. An analysis of individual participant data using Cox regression was carried out using data from 11 case cohorts. Results We identified 11 published studies suitable for inclusion in the meta-analysis. Moderate post-diagnosis alcohol consumption was not associated with overall survival [HR, 0.95; 95% confidence interval (CI), 0.85–1.05], but there was some evidence of better survival associated with prediagnosis consumption (HR, 0.80; 95% CI, 0.73–0.88). Individual data on alcohol consumption for 29,239 cases with 4,839 deaths were available from the 11 case cohorts, all of which had data on estrogen receptor (ER) status. For women with ER-positive disease, there was little evidence that pre- or postdiagnosis alcohol consumption is associated with breast cancer–specific mortality, with some evidence of a negative association with all-cause mortality. On the basis of a single study, moderate postdiagnosis alcohol intake was associated with a small reduction in breast cancer–specific mortality for women with ER-negative disease. There was no association with prediagnosis intake for women with ER-negative disease. Conclusion There was little evidence that pre- or post-diagnosis alcohol consumption is associated with breast cancer–specific mortality for women with ER-positive disease. There was weak evidence that moderate post-diagnosis alcohol intake is associated with a small reduction in breast cancer–specific mortality in ER-negative disease. Impact Considering the totality of the evidence, moderate postdiagnosis alcohol consumption is unlikely to have a major adverse effect on the survival of women with breast cancer.

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“…These findings suggest that there could be factors other than the biological or treatment factors that could have contributed to the superior survival in the high EL group. A range of factors were presumed to be included in this category: adherence to breast cancer screening [ 22 ], socioeconomic status [ 21 , 23 - 25 ], exercise [ 26 ], diet [ 26 ], smoking [ 27 - 29 ], etc.…”

Section: Discussionmentioning

confidence: 99%

Education Level Is a Strong Prognosticator in the Subgroup Aged More Than 50 Years Regardless of the Molecular Subtype of Breast Cancer: A Study Based on the Nationwide Korean Breast Cancer Registry Database

Hwang

Noh²,

Cho

et al. 2017

Cancer Res Treat

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PurposeThis study investigated the role of the education level (EL) as a prognostic factor for breast cancer and analyzed the relationship between the EL and various confounding factors.Materials and MethodsThe data for 64,129 primary breast cancer patients from the Korean Breast Cancer Registry were analyzed. The EL was classified into two groups according to the education period; the high EL group (≥ 12 years) and low EL group (< 12 years). Survival analyses were performed with respect to the overall survival between the two groups.ResultsA high EL conferred a superior prognosis compared to a low EL in the subgroup aged > 50 years (hazard ratio, 0.626; 95% confidence interval [CI], 0.577 to 0.678) but not in the subgroup aged ≤ 50 years (hazard ratio, 0.941; 95% CI, 0.865 to 1.024). The EL was a significant independent factor in the subgroup aged > 50 years according to multivariate analyses. The high EL group showed more favorable clinicopathologic features and a higher proportion of patients in this group received lumpectomy, radiation therapy, and endocrine therapy. In the high EL group, a higher proportion of patients received chemotherapy in the subgroups with unfavorable clinicopathologic features. The EL was a significant prognosticator across all molecular subtypes of breast cancer.ConclusionThe EL is a strong independent prognostic factor for breast cancer in the subgroup aged > 50 years regardless of the molecular subtype, but not in the subgroup aged ≤ 50 years. Favorable clinicopathologic features and active treatments can explain the main causality of the superior prognosis in the high EL group.

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Abstract: This study suggests compromised breast cancer survival among postmenopausal women who reported drinking at least one alcoholic beverage per week, a preliminary finding that warrants further investigation.

Cited by 40 publications

References 38 publications

Alcohol intake and mortality among women with invasive breast cancer

Alcohol intake and mortality among women with invasive breast cancer

Alcohol Consumption and Survival after a Breast Cancer Diagnosis: A Literature-Based Meta-analysis and Collaborative Analysis of Data for 29,239 Cases

Education Level Is a Strong Prognosticator in the Subgroup Aged More Than 50 Years Regardless of the Molecular Subtype of Breast Cancer: A Study Based on the Nationwide Korean Breast Cancer Registry Database

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