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El-Yazigi, Adnan; Raines, Dale A.; Ali, Hatim; Sieck, Jens O.; Ernst, Peter; Døssing, Martin

doi:10.1023/a:1015816825920

Cited by 15 publications

(2 citation statements)

References 16 publications

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“…The aminopyrine content (g per tablet, g mL À1 ) in the samples were also determined by HPLC according to a previously reported method. 33 The results are also listed in Table 2. There was no significant difference between the results obtained by the HPLC method and Bi 2 S 3 / GCE.…”

Section: Analytical Applicationmentioning

confidence: 99%

Electrochemical behavior of antipyrine at a Bi2S3 modified glassy carbon electrode and its determination in pharmaceutical formulations

Meng

Wang

et al. 2012

Anal. Methods

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Section: Analytical Applicationmentioning

confidence: 99%

Electrochemical behavior of antipyrine at a Bi2S3 modified glassy carbon electrode and its determination in pharmaceutical formulations

Meng

Wang

et al. 2012

Anal. Methods

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“…Several research studies have revealed that there is a direct association of macro and trace elements with diabetes mellitus [6]. Diabetes mellitus has been found to be associated with abnormalities in the metabolism of some of the elements such as Cu, Zn, Fe, Se, Mg, Cr, V, Ca and K [7,8]. Leptadenia hastata (Pers) Decne (Family-Asclepiadaceae), commonly known as yadiya is an edible nondomesticated vegetable collected in wild throughout Africa.…”

Section: Introductionmentioning

confidence: 99%

PHYSICO-CHEMICAL AND PHYTOCHEMICAL SCREENING OF n-HEXANE EXTRACT OF LEPTADENIA HASTATA LEAVES: A PROPOSED HERBAL REMEDY IN THE TREATMENT OF DIABETES MELLITUS

M.O.O

T.W

Garba

et al. 2019

Int. J. Res. Granthaalayah

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Background: Leptadenia hastata is a leafy, climbing plant of whose root, leaf and bark is widely consumed in Northern Nigeria. Decoctions made from the leaf is locally used in treatment of diabetes as well as for numerous trado-medicinal processes. This study investigates the physico-chemical as well as phytochemical compounds present in the n-hexane extract of Leptadenia hastata. Method: Physical and chemical profile was determined using Smart Spectro test kits and a mass spectrometer to determine the presence of elements and physical properties. Results: Phytochemical analysis revealed the presence of steroids, triterpenoids and cardiac glycosides. The elemental analysis revealed that Na, SO4 and PO4 had the highest levels in the extract. Pb, Hg and Cd were not detected which showed that the plant extract was not toxic. Other elements (NO4, Mn, Fe, K, Ni, Si, Cn, Zn, Ca, Mg, NH4, Cr and F) were present in varying concentrations which may contribute to its nutritive composition. Conclusions: Various elements present in Leptadenia hastata may have either a direct or indirect role in the control and management of diabetes mellitus, since diabetes is associated with marked alterations in trace elements concentrations and may replace diminished element stores in the treatment of diabetes mellitus.

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Relationship Between Antipyrine Metabolism and Acetylation Phenotype in Health and Chronic Liver Diseases

El-Yazigi

Raines

Wahab

et al. 1995

The Journal of Clinical Pharma

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The authors examined the activity of N-acetyltransferase and that of microsomal P-450 isoenzymes in health and hepatic disease state by determining the acetylation phenotype and the total (CLAP) and metabolic clearances of antipyrine to form norantipyrine or N-demethylantipyrine (MCLnora), 3-hydroxymethylantipyrine (MCLhma), and 4-hydroxyantipyrine (MCLha) in 21 healthy subjects and in 33 patients with chronic liver diseases (CLD) and investigated the relationship between the activities of these two enzyme systems. The acetylation phenotype was determined according to the urinary caffeine metabolites test. The mean and (SEM) of CLAP, MCLhma, MCLha, and MCLnora in healthy subjects were 2.42 (0.264), 0.193 (0.031), 0.322 (0.045), and 0.288 (0.04) L/h, and those observed in patients with CLD were 0.98 (0.1), 0.076 (0.015), 0.131 (0.026), 0.103 (0.022) L/h, respectively. The prevalence of fast acetylation among the healthy subjects and patients with CLD was 38% and 39%, respectively. Although all metabolic clearances appear to be reduced in healthy slow acetylators, the reduction was only significant in MCLnora, indicating a direct association between the activity of N-acetyltransferase and that of P-450 IIIA3 responsible for the N-demethylation of antipyrine. Conversely, slow acetylators with CLD exhibited significantly higher CLAP and near-significantly larger metabolic clearances including MCLnora, which suggests that P-450 activity in fast acetylators is more sensitive to chronic liver diseases than in slow acetylators.

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Untitled

Cited by 15 publications

References 16 publications

Electrochemical behavior of antipyrine at a Bi2S3 modified glassy carbon electrode and its determination in pharmaceutical formulations

Electrochemical behavior of antipyrine at a Bi2S3 modified glassy carbon electrode and its determination in pharmaceutical formulations

PHYSICO-CHEMICAL AND PHYTOCHEMICAL SCREENING OF n-HEXANE EXTRACT OF LEPTADENIA HASTATA LEAVES: A PROPOSED HERBAL REMEDY IN THE TREATMENT OF DIABETES MELLITUS

Relationship Between Antipyrine Metabolism and Acetylation Phenotype in Health and Chronic Liver Diseases

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