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Dubok, V. A.

doi:10.1023/a:1026617607548

Cited by 135 publications

(27 citation statements)

References 30 publications

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“…For example, use of bone implants from corpses or animals, even after they have been treated in various ways, provokes a negative immune reaction in the organism, which substantially limits the application of such implants. In this connection, it is useful to dwell on the biological properties of bioceramic implants, particularly those of calcium orthophosphates, which in the course of time may be resorbed completely [530]. …”

Section: Biological Properties and In Vivo Behaviormentioning

confidence: 99%

Calcium Orthophosphates as Bioceramics: State of the Art

Dorozhkin¹

2010

JFB

203

108

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In the late 1960s, much interest was raised in regard to biomedical applications of various ceramic materials. A little bit later, such materials were named bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30–40 years. Namely, by structural and compositional control, it became possible to choose whether calcium orthophosphate bioceramics were biologically stable once incorporated within the skeletal structure or whether they were resorbed over time. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics—which is able to promote regeneration of bones—was developed. Presently, calcium orthophosphate bioceramics are available in the form of particulates, blocks, cements, coatings, customized designs for specific applications and as injectable composites in a polymer carrier. Current biomedical applications include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmentation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Exploratory studies demonstrate potential applications of calcium orthophosphate bioceramics as scaffolds, drug delivery systems, as well as carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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Section: Biological Properties and In Vivo Behaviormentioning

confidence: 99%

Calcium Orthophosphates as Bioceramics: State of the Art

Dorozhkin¹

2010

JFB

203

108

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“…First, they must be bioinert or bioactive [12]; the former means that the organism has a coexistence with the material without noticeable change in the organism and/or exogenous material, whereas the latter implies that there is an interaction with and/or a response from living tissue, e.g., the formation of direct biochemical bonds with the surface of the material in bioceramics. Further, they must not It is widely reported [14,24] that bones are subjected to a stress of about 4 MPa on a daily basis and hip joints may experience a load as high as 10 times of the body weight in some cases, these implantable devices require high properties in terms of (1) and (2).…”

Section: Introductionmentioning

confidence: 99%

Mg and Its Alloys for Biomedical Applications: Exploring Corrosion and Its Interplay with Mechanical Failure

Peron

Torgersen

Berto

2017

Metals

101

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Abstract:The future of biomaterial design will rely on temporary implant materials that degrade while tissues grow, releasing no toxic species during degradation and no residue after full regeneration of the targeted anatomic site. In this aspect, Mg and its alloys are receiving increasing attention because they allow both mechanical strength and biodegradability. Yet their use as biomedical implants is limited due to their poor corrosion resistance and the consequential mechanical integrity problems leading to corrosion assisted cracking. This review provides the reader with an overview of current biomaterials, their stringent mechanical and chemical requirements and the potential of Mg alloys to fulfil them. We provide insight into corrosion mechanisms of Mg and its alloys, the fundamentals and established models behind stress corrosion cracking and corrosion fatigue. We explain Mgs unique negative differential effect and approaches to describe it. Finally, we go into depth on corrosion improvements, reviewing literature on high purity Mg, on the effect of alloying elements and their tolerance levels, as well as research on surface treatments that allow to tune degradation kinetics. Bridging fundamentals aspects with current research activities in the field, this review intends to give a substantial overview for all interested readers; potential and current researchers and practitioners of the future not yet familiar with this promising material.

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“…Though, the word "apatite" was revealed in the 1990s and is denoted as calcium orthophosphate, which would be a very infrequent heterogeneity of tourmaline, beryl and other stones [1]. The period of HAp in reformative science backdate to 1950s [2] furthermore for the illing of the bone defects, the bioceramics might be used as an inert scafold. The history related to calcium orthophosphates dates back to 1770 [3] the mistaken for other minerals, such as beryl, tourmaline, chrysolite, amethyst, luorite, etc., [1,4,5].…”

Section: A Terse Testament Of Hydroxyapatitementioning

confidence: 99%

Introductory Chapter: The Testament of Hydroxyapatite: New Prospects in Regenerative Medicinal Treatments

Thirumalai¹

2018

Hydroxyapatite - Advances in Composite Nanomaterials, Biomedical Applications and Its Technological Facets

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Untitled

Cited by 135 publications

References 30 publications

Calcium Orthophosphates as Bioceramics: State of the Art

Calcium Orthophosphates as Bioceramics: State of the Art

Mg and Its Alloys for Biomedical Applications: Exploring Corrosion and Its Interplay with Mechanical Failure

Introductory Chapter: The Testament of Hydroxyapatite: New Prospects in Regenerative Medicinal Treatments

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