Untitled

Waksman, Byron H.

doi:10.1023/a:1022527628192

Cited by 11 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While describing paradigm shifts for the pathogenesis of MS, he wrote: “EAE, the autoimmunity-based animal model, is not seen as inherently superior to (viral) models like Visna or TMEV. One might be right to regard autoimmunity (as a cause for MS) as a paradigm shift that never quite made it!” ( 18 ).…”

Section: Fiction #1 Ms Is An Autoimmune Diseasementioning

confidence: 99%

See 1 more Smart Citation

The Neuroimmunology of Multiple Sclerosis: Fictions and Facts

Pachner

2022

Front. Neurol.

View full text Add to dashboard Cite

There have been tremendous advances in the neuroimmunology of multiple sclerosis over the past five decades, which have led to improved diagnosis and therapy in the clinic. However, further advances must take into account an understanding of some of the complex issues in the field, particularly an appreciation of “facts” and “fiction.” Not surprisingly given the incredible complexity of both the nervous and immune systems, our understanding of the basic biology of the disease is very incomplete. This lack of understanding has led to many controversies in the field. This review identifies some of these controversies and facts/fictions with relation to the basic neuroimmunology of the disease (cells and molecules), and important clinical issues. Fortunately, the field is in a healthy transition from excessive reliance on animal models to a broader understanding of the disease in humans, which will likely lead to many improved treatments especially of the neurodegeneration in multiple sclerosis (MS).

show abstract

Section: Fiction #1 Ms Is An Autoimmune Diseasementioning

confidence: 99%

“…One might be right to regard autoimmunity (as a cause for MS) as a paradigm shift that never quite made it!" (18).…”

Section: Fiction #1 Ms Is An Autoimmune Disease Fact #1 Ms Has a Defi...mentioning

confidence: 99%

The Neuroimmunology of Multiple Sclerosis: Fictions and Facts

Pachner

2022

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…Several point mutations in P2 have been identified as causes of Charcot–Marie–Tooth (CMT) disease, which is one of the hereditary human neuropathies and modulates nerve transmission in both motor and sensory nerves in the PNS [ 62 ]. Furthermore, a lack of MBP causes primarily demyelinating disease [ 63 ]. Since lipid membranes are characterized by their dynamic fluidity, an understanding of the molecular dynamics of lipids and their changes caused by the insertion of relevant proteins, as well as the dynamics of myelin-constituting proteins, is important to reveal the molecular mechanism of the myelin function and its relevant diseases.…”

Section: Ins Studies On Pathologically Relevant Bio-macromoleculesmentioning

confidence: 99%

Sub-Nanosecond Dynamics of Pathologically Relevant Bio-Macromolecules Observed by Incoherent Neutron Scattering

Matsuo

Peters

2022

Life

View full text Add to dashboard Cite

Incoherent neutron scattering (iNS) is one of the most powerful techniques to study the dynamical behavior of bio-macromolecules such as proteins and lipid molecules or whole cells. This technique has widely been used to elucidate the fundamental aspects of molecular motions that manifest in the bio-macromolecules in relation to their intrinsic molecular properties and biological functions. Furthermore, in the last decade, iNS studies focusing on a possible relationship between molecular dynamics and biological malfunctions, i.e., human diseases and disorders, have gained importance. In this review, we summarize recent iNS studies on pathologically relevant proteins and lipids and discuss how the findings are of importance to elucidate the molecular mechanisms of human diseases and disorders that each study targets. Since some diseases such as amyloidosis have become more relevant in the aging society, research in this field will continue to develop further and be more important in the current increasing trend for longevity worldwide.

show abstract

Untitled

Cited by 11 publications

References 10 publications

The Neuroimmunology of Multiple Sclerosis: Fictions and Facts

The Neuroimmunology of Multiple Sclerosis: Fictions and Facts

Sub-Nanosecond Dynamics of Pathologically Relevant Bio-Macromolecules Observed by Incoherent Neutron Scattering

Making the White Matter Matters: Progress in Understanding Canavan’s Disease and Therapeutic Interventions Through Eight Decades

Contact Info

Product

Resources

About