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DNA Binding and cleavage activity of Ni(II) complex with all-trans retinoic acid

“…The complex of [Ni(RA) 2 (H 2 O) 2 ] AE H 2 O was synthesized by methods described previously [6]. The ligand HRA (2.0 mM) in absolute EtOH (Ethanol absolute) (80 ml) was stirred at room temperature for 30 min.…”

“…HRA is the most effective medicine for curing acute promyelocytic leukemia (APL) at present and HRA also has certain effects on various cancers [4,5], so its derivatives have aroused great interest in various areas of medicine and chemistry [6]. It is reported that the metal complexes of HRA have much better antitumor effects [6].…”

“…It is reported that the metal complexes of HRA have much better antitumor effects [6]. For example, the antitumor experiments indicate that the Sm(III), Y(III), Cu(II)and Ni(II) complexes of all-trans retinoic acid have greater effects on human bladder cancer line EJ cells than that of HRA [7,8].…”