Untitled

Abstract

Background: Phenolic compounds are ubiquitous in dietary fruits and vegetables and have been proposed to have antioxidant, antibacterial, anti-inflammatory, and anticancer effects. Voltage gated K + channels (I K ) contribute to various cellular mechanisms involved in the tumor cell progression. Therefore, the modulation of I K current may be a potential target for cancer therapy. In this study, we electrophysiologically characterized four phenolic compounds for their modulatory activities on I K currents. Materials and Methods: The whole cell configuration of the patch clamp recording technique was used to record the I K currents from human prostate cancer line (LNCaP). In addition, 200 µM of phenolic compounds (curcumin, resveratrol, rutin, and troxerutin) were externally perfused to the cells. Results: Obtained results provide evidence that resveratrol at 200 µM inhibited more than half of the I K current amplitude. On the other hand, curcumin, rutin, and troxerutin did not show any modulatory effect on I K current in LNCaP cells. Conclusion: This study demonstrates that not all the anticancer compounds are effective inhibitors of I K current, but only few of them. The I K current inhibitors might exhibit effective antimetastatic properties.