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doi:10.18632/aging.v14i1

Cited by 2 publications

(2 citation statements)

References 8 publications

(9 reference statements)

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“…In addition, meta-analyses by Hung et al. involving patients with AD vs a control group showed increased amounts of Proteobacteria, Firmicutes, Clostridiaceae, Lachnospiraceae and Rikenellaceae in the AD spectrum group ( Hung et al., 2022 ). Research on the gut microbiome in the course of CD and AD has revealed a decrease in the levels of Prevotellaceae , Firmicutes , Actinobacteria , and Eubacterium .…”

Section: Crohn’s Disease Association With Alzheimer’s Diseasementioning

confidence: 99%

“…The most significant changes involve genera: Firmicutes, Bifidobacterium, Actinobacteria, Eubacteria, and Bacteroidetes, as well as E. coli, Shigella spp., and Salmonella spp (Vogt et al, 2017). In addition, meta-analyses by Hung et al involving patients with AD vs a control group showed increased amounts of Proteobacteria, Firmicutes, Clostridiaceae, Lachnospiraceae and Rikenellaceae in the AD spectrum group (Hung et al, 2022). Research on the gut microbiome in the course of CD and AD has revealed a decrease in the levels of Prevotellaceae, Firmicutes, Actinobacteria, and Eubacterium.…”

Section: Dysbiosis Of the Intestinal Microbiotamentioning

confidence: 99%

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Amyloid, Crohn’s disease, and Alzheimer’s disease - are they linked?

Duda-Madej,

Stecko,

Szymańska

et al. 2024

Front. Cell. Infect. Microbiol.

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Crohn’s disease (CD) is a chronic inflammatory disease that most frequently affects part of the distal ileum, but it may affect any part of the gastrointestinal tract. CD may also be related to systemic inflammation and extraintestinal manifestations. Alzheimer’s disease (AD) is the most common neurodegenerative disease, gradually worsening behavioral and cognitive functions. Despite the meaningful progress, both diseases are still incurable and have a not fully explained, heterogeneous pathomechanism that includes immunological, microbiological, genetic, and environmental factors. Recently, emerging evidence indicates that chronic inflammatory condition corresponds to an increased risk of neurodegenerative diseases, and intestinal inflammation, including CD, increases the risk of AD. Even though it is now known that CD increases the risk of AD, the exact pathways connecting these two seemingly unrelated diseases remain still unclear. One of the key postulates is the gut-brain axis. There is increasing evidence that the gut microbiota with its proteins, DNA, and metabolites influence several processes related to the etiology of AD, including β-amyloid abnormality, Tau phosphorylation, and neuroinflammation. Considering the role of microbiota in both CD and AD pathology, in this review, we want to shed light on bacterial amyloids and their potential to influence cerebral amyloid aggregation and neuroinflammation and provide an overview of the current literature on amyloids as a potential linker between AD and CD.

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Section: Crohn’s Disease Association With Alzheimer’s Diseasementioning

confidence: 99%

Section: Dysbiosis Of the Intestinal Microbiotamentioning

confidence: 99%

Amyloid, Crohn’s disease, and Alzheimer’s disease - are they linked?

Duda-Madej,

Stecko,

Szymańska

et al. 2024

Front. Cell. Infect. Microbiol.

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Adipose Mesenchymal Stem Cell-Derived Exosomes Promote the Regeneration of Corneal Endothelium Through Ameliorating Senescence

Ryu,

Hwang,

Bo Noh

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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Purpose Human corneal endothelial cells (hCECs) have been considered unable to regenerate in vivo, resulting in corneal decompensation after significant loss of hCECs. adipose-derived mesenchymal stem cell (ASC)-derived exosomes can regenerate tissues and organs. In this study, we investigated whether ASC-derived exosomes could protect and regenerate CECs. Methods We performed cell viability and cell-cycle analyses to evaluate the effect of ASC-derived exosomes on the regeneration capacity of cultured hCECs. Transforming growth factor-β (TGF-β) and hydrogen peroxide (H 2 O 2 ) were used to induce biological stress in CECs. The effect of ASC-derived exosomes on CECs was investigated in vivo. ASC-derived exosomes were introduced into rat CECs using electroporation, and rat corneas were injured using cryoinjury. Next-generation sequencing analysis was performed to compare the differentially expressed microRNAs (miRNAs) between ASC-derived and hCEC-derived exosomes. Results ASC-derived exosomes induced CEC proliferation and suppressed TGF-β- or H 2 O 2 -induced oxidative stress and senescence. ASC-derived exosomes protect hCECs against TGF-β- or H 2 O 2 -induced endothelial-mesenchymal transition and mitophagy. In an in vivo study, ASC-derived exosomes promoted wound healing of rat CECs and protected the corneal endothelium against cryoinjury-induced corneal endothelium damage. Next-generation sequencing analysis revealed differentially expressed miRNAs for ASC-derived and hCEC-derived exosomes. They are involved in lysine degradation, adherens junction, the TGF-β signaling pathway, the p53 signaling pathway, the Hippo signaling pathway, the forkhead box O (FoxO) signaling pathway, regulation of actin cytoskeleton, and RNA degradation based on Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Conclusions ASC-derived exosomes promoted wound healing and regeneration of endothelial cells by inducing a shift in the cell cycle and suppressing senescence and autophagy.

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Untitled

Cited by 2 publications

References 8 publications

Amyloid, Crohn’s disease, and Alzheimer’s disease - are they linked?

Amyloid, Crohn’s disease, and Alzheimer’s disease - are they linked?

Adipose Mesenchymal Stem Cell-Derived Exosomes Promote the Regeneration of Corneal Endothelium Through Ameliorating Senescence

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