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Abstract

Serum soluble interleukin-2 receptor (sIL-2R) levels were determined in patients with chronic myeloproliferative disorders (CMPD): 18 with chronic myelogenous leukemia in chronic phase (CML in CP), seven with CML in accelerated phase (AP) or blastic crisis (BC), six with polycythemia vera (PV), eight with essential thrombocythemia (ET), one with primary myelofibrosis (PMF), and 50 controls. The mean (+/-S.E.M.) levels were higher in CMPD than in controls (CML in AP or BC, 2693 +/- 694 U/ml, P < 0.0001; CML in CP, 792 +/- 63 U/ml, P < 0.0001; PV 553 +/- 89 U/ml, P < 0.05; ET, 449 +/- 56 U/ml; PMF, 628 U/ml vs. controls, 395 +/- 25 U/ml). Patients with CML in CP had significantly higher serum sIL-2R levels than patients with ET (P < 0.005), and levels were markedly elevated in AP and BC (P < 0.001). Serum sIL-2R levels were positively correlated with WBC count and lactic dehydrogenase in CMPD, and in CML in CP. Serum sIL-2R levels in CMPD were negatively correlated with RBC and platelet counts. Serum sIL-2R levels were significantly lower in patients with CML in CP who showed a cytogenetic response after interferon (IFN) therapy than in those who showed no response (P < 0.05). These findings suggest that a high serum sIL-2R level reflects the leukocyte growth in CMPD and is useful both for differentiating CML from other CMPD and for predicting the response to IFN therapy in CML.

Increased Level of Myeloid-Derived Suppressor Cells, Programmed Death Receptor Ligand 1/Programmed Death Receptor 1, and Soluble CD25 in Sokal High Risk Chronic Myeloid Leukemia

“…Several studies have shown that patients in advanced stages of disease have higher levels of sCD25 in plasma compared to patients in less advance stages and that sCD25 can be a prognostic factor for patients with lymphoma [47], [49], [50], [51], [52]. In CML, patients in accelerated phase and blast crisis have higher levels of sCD25 in plasma [47], [50]. In the present paper we show that the level of sCD25 in plasma is higher in HR patients.…”

“…We as well as others have shown that patients with hematological malignancies, such as B cell malignancies and CML, have increased level of sCD25 in plasma [21], [23], [47], [48]. Several studies have shown that patients in advanced stages of disease have higher levels of sCD25 in plasma compared to patients in less advance stages and that sCD25 can be a prognostic factor for patients with lymphoma [47], [49], [50], [51], [52]. In CML, patients in accelerated phase and blast crisis have higher levels of sCD25 in plasma [47], [50].…”

Circulating Cytokine Levels as Markers of Inflammation in Philadelphia Negative Myeloproliferative Neoplasms: Diagnostic and Prognostic Interest

“…The first experimental data that showed elevations of serum and/or plasma cytokines in Ph− MPN date back to more than 15 years. In the 90s, changes in serum levels of interleukin (IL) such as IL6 [ 5 , 6 ], IL2 and its soluble receptor [ 7 ], and of tumor necrosis factor (TNF α ) [ 8 ] were already reported associated with disturbances of blood cell counts. The study of Hermouet et al [ 9 ] in 2002 has expanded this panel, showing elevated serum levels of IL8 and IL11 in patients with PV, compared to healthy subjects.…”

Inflammatory Pathophysiology as a Contributor to Myeloproliferative Neoplasms

“…Patients with primary myelofibrosis (PMF) have been shown to share both clinical symptoms and laboratory abnormalities with patients with systemic inflammatory response syndrome, such as elevation in the erythrocyte sedimentation rate, Creactive protein (CRP), IL-1b, IL-6, IL-8, and TNF (54). High plasma levels of IL-6 and IL-8 were found to be significantly associated with severity of constitutional symptoms in PMF patients by Tefferi et al (43) Elevations of IL-2, and sIL-2R, Il-6, IL-8, and b2-microglobulin, have been associated with blast transformation of CML or Ph-MPNs, based on several studies (43,50,51,55). IL-8, also known as CXCL8, is a CXC family cytokine found to be expressed by HSPC in MF (48) and de novo AML (56) patients.…”